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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSC
All Species:
13.64
Human Site:
S290
Identified Species:
23.08
UniProt:
P53634
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53634
NP_001805.3
463
51842
S290
L
S
P
Q
E
V
V
S
C
S
Q
Y
A
Q
G
Chimpanzee
Pan troglodytes
XP_508684
463
51907
S290
L
S
P
Q
E
V
V
S
C
S
Q
Y
A
Q
G
Rhesus Macaque
Macaca mulatta
XP_001104734
463
51874
S290
L
S
P
Q
E
V
V
S
C
S
Q
Y
A
Q
G
Dog
Lupus familis
XP_535784
481
54085
S311
P
Q
E
I
V
S
C
S
Q
Y
A
Q
G
C
E
Cat
Felis silvestris
Mouse
Mus musculus
P97821
462
52358
C290
S
P
Q
E
V
V
S
C
S
P
Y
A
Q
G
C
Rat
Rattus norvegicus
P80067
462
52217
C290
S
P
Q
E
V
V
S
C
S
P
Y
A
Q
G
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512140
469
52438
S296
L
S
T
Q
Q
I
V
S
C
S
E
Y
S
Q
G
Chicken
Gallus gallus
P43233
340
37569
G178
G
L
Y
D
S
H
V
G
C
R
A
Y
T
I
P
Frog
Xenopus laevis
NP_001080511
458
51565
Q291
V
S
C
S
N
Y
S
Q
G
C
D
G
G
F
P
Zebra Danio
Brachydanio rerio
NP_999887
455
50596
C291
C
S
Q
Y
S
Q
G
C
D
G
G
F
P
Y
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P43510
379
42386
K217
P
C
E
H
H
S
K
K
T
H
F
D
P
C
P
Sea Urchin
Strong. purpuratus
XP_001201161
459
51309
G293
E
Y
S
Q
G
C
E
G
G
F
P
Y
L
V
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q10717
360
39181
C198
S
E
Q
Q
L
V
D
C
G
F
A
F
N
N
F
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H166
358
38941
C196
S
E
Q
Q
L
V
D
C
A
G
A
F
N
N
Y
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
95.6
79
N.A.
77.7
78.6
N.A.
72
22.8
62.4
63.2
N.A.
N.A.
N.A.
23.3
54.8
Protein Similarity:
100
99.7
97.4
85.4
N.A.
86.6
87
N.A.
83.5
38
77.3
77.1
N.A.
N.A.
N.A.
38.2
71.4
P-Site Identity:
100
100
100
6.6
N.A.
6.6
6.6
N.A.
66.6
20
6.6
6.6
N.A.
N.A.
N.A.
0
13.3
P-Site Similarity:
100
100
100
6.6
N.A.
13.3
13.3
N.A.
93.3
20
13.3
13.3
N.A.
N.A.
N.A.
0
13.3
Percent
Protein Identity:
N.A.
27.8
N.A.
27
N.A.
N.A.
Protein Similarity:
N.A.
42.5
N.A.
43.2
N.A.
N.A.
P-Site Identity:
N.A.
13.3
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
20
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
8
0
29
15
22
0
8
% A
% Cys:
8
8
8
0
0
8
8
36
36
8
0
0
0
15
15
% C
% Asp:
0
0
0
8
0
0
15
0
8
0
8
8
0
0
0
% D
% Glu:
8
15
15
15
22
0
8
0
0
0
8
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
15
8
22
0
8
8
% F
% Gly:
8
0
0
0
8
0
8
15
22
15
8
8
15
15
29
% G
% His:
0
0
0
8
8
8
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
8
0
0
0
0
0
0
0
8
0
% I
% Lys:
0
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% K
% Leu:
29
8
0
0
15
0
0
0
0
0
0
0
8
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
0
0
0
0
0
15
15
0
% N
% Pro:
15
15
22
0
0
0
0
0
0
15
8
0
15
0
22
% P
% Gln:
0
8
36
50
8
8
0
8
8
0
22
8
15
29
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% R
% Ser:
29
43
8
8
15
15
22
36
15
29
0
0
8
0
0
% S
% Thr:
0
0
8
0
0
0
0
0
8
0
0
0
8
0
0
% T
% Val:
8
0
0
0
22
50
36
0
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
8
8
0
8
0
0
0
8
15
43
0
8
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _