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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSC
All Species:
40.61
Human Site:
T445
Identified Species:
68.72
UniProt:
P53634
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53634
NP_001805.3
463
51842
T445
Y
F
R
I
R
R
G
T
D
E
C
A
I
E
S
Chimpanzee
Pan troglodytes
XP_508684
463
51907
T445
Y
F
R
I
R
R
G
T
D
E
C
A
I
E
S
Rhesus Macaque
Macaca mulatta
XP_001104734
463
51874
T445
Y
F
R
I
R
R
G
T
D
E
C
A
I
E
S
Dog
Lupus familis
XP_535784
481
54085
T463
Y
F
Q
I
C
R
G
T
D
E
C
A
I
E
S
Cat
Felis silvestris
Mouse
Mus musculus
P97821
462
52358
T444
Y
F
R
I
R
R
G
T
D
E
C
A
I
E
S
Rat
Rattus norvegicus
P80067
462
52217
T444
Y
F
R
I
R
R
G
T
D
E
C
A
I
E
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512140
469
52438
S451
Y
F
R
I
R
R
G
S
D
E
C
A
I
E
S
Chicken
Gallus gallus
P43233
340
37569
E323
G
E
D
H
C
G
I
E
S
E
I
V
A
G
V
Frog
Xenopus laevis
NP_001080511
458
51565
S440
F
F
R
I
R
R
G
S
D
E
C
A
I
E
S
Zebra Danio
Brachydanio rerio
NP_999887
455
50596
T437
F
F
R
I
R
R
G
T
D
E
C
A
I
E
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P43510
379
42386
L362
G
I
P
K
L
N
S
L
T
S
R
L
H
R
H
Sea Urchin
Strong. purpuratus
XP_001201161
459
51309
T442
Y
F
R
I
R
R
G
T
D
E
C
A
I
E
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q10717
360
39181
M343
E
G
Y
F
K
M
E
M
G
K
N
M
C
G
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H166
358
38941
M341
K
G
Y
F
K
M
E
M
G
K
N
M
C
G
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
95.6
79
N.A.
77.7
78.6
N.A.
72
22.8
62.4
63.2
N.A.
N.A.
N.A.
23.3
54.8
Protein Similarity:
100
99.7
97.4
85.4
N.A.
86.6
87
N.A.
83.5
38
77.3
77.1
N.A.
N.A.
N.A.
38.2
71.4
P-Site Identity:
100
100
100
86.6
N.A.
100
100
N.A.
93.3
6.6
86.6
93.3
N.A.
N.A.
N.A.
0
100
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
100
6.6
100
100
N.A.
N.A.
N.A.
0
100
Percent
Protein Identity:
N.A.
27.8
N.A.
27
N.A.
N.A.
Protein Similarity:
N.A.
42.5
N.A.
43.2
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
72
8
0
0
% A
% Cys:
0
0
0
0
15
0
0
0
0
0
72
0
15
0
0
% C
% Asp:
0
0
8
0
0
0
0
0
72
0
0
0
0
0
0
% D
% Glu:
8
8
0
0
0
0
15
8
0
79
0
0
0
72
0
% E
% Phe:
15
72
0
15
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
15
15
0
0
0
8
72
0
15
0
0
0
0
22
0
% G
% His:
0
0
0
8
0
0
0
0
0
0
0
0
8
0
8
% H
% Ile:
0
8
0
72
0
0
8
0
0
0
8
0
72
0
8
% I
% Lys:
8
0
0
8
15
0
0
0
0
15
0
0
0
0
0
% K
% Leu:
0
0
0
0
8
0
0
8
0
0
0
8
0
0
0
% L
% Met:
0
0
0
0
0
15
0
15
0
0
0
15
0
0
0
% M
% Asn:
0
0
0
0
0
8
0
0
0
0
15
0
0
0
0
% N
% Pro:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
65
0
65
72
0
0
0
0
8
0
0
8
0
% R
% Ser:
0
0
0
0
0
0
8
15
8
8
0
0
0
0
72
% S
% Thr:
0
0
0
0
0
0
0
58
8
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
58
0
15
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _