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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSC
All Species:
13.03
Human Site:
Y170
Identified Species:
22.05
UniProt:
P53634
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53634
NP_001805.3
463
51842
Y170
Y
S
N
R
L
Y
K
Y
D
H
N
F
V
K
A
Chimpanzee
Pan troglodytes
XP_508684
463
51907
Y170
Y
S
N
R
L
Y
K
Y
D
H
N
F
V
K
A
Rhesus Macaque
Macaca mulatta
XP_001104734
463
51874
Y170
Y
S
N
R
L
Y
K
Y
D
H
N
F
V
K
A
Dog
Lupus familis
XP_535784
481
54085
Y191
N
S
N
R
L
Y
K
Y
N
Y
E
F
V
K
A
Cat
Felis silvestris
Mouse
Mus musculus
P97821
462
52358
H170
Y
S
E
R
L
Y
T
H
N
H
N
F
V
K
A
Rat
Rattus norvegicus
P80067
462
52217
H170
Y
S
E
R
L
Y
S
H
N
H
N
F
V
K
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512140
469
52438
N176
L
P
K
K
L
Y
Q
N
H
P
D
F
V
S
T
Chicken
Gallus gallus
P43233
340
37569
L58
D
M
S
Y
V
K
K
L
C
G
T
F
L
G
G
Frog
Xenopus laevis
NP_001080511
458
51565
V171
Y
N
Y
N
H
D
F
V
K
Q
I
N
T
V
Q
Zebra Danio
Brachydanio rerio
NP_999887
455
50596
I171
N
M
M
F
V
D
E
I
N
S
V
Q
K
S
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P43510
379
42386
K97
K
G
K
Q
H
L
S
K
T
K
D
L
D
L
D
Sea Urchin
Strong. purpuratus
XP_001201161
459
51309
K173
N
D
K
K
M
V
E
K
I
N
R
A
Q
K
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q10717
360
39181
K78
E
S
A
A
E
V
H
K
R
F
R
I
F
S
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H166
358
38941
M76
K
Y
Q
N
V
E
E
M
K
L
R
F
S
I
F
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
95.6
79
N.A.
77.7
78.6
N.A.
72
22.8
62.4
63.2
N.A.
N.A.
N.A.
23.3
54.8
Protein Similarity:
100
99.7
97.4
85.4
N.A.
86.6
87
N.A.
83.5
38
77.3
77.1
N.A.
N.A.
N.A.
38.2
71.4
P-Site Identity:
100
100
100
73.3
N.A.
73.3
73.3
N.A.
26.6
13.3
6.6
0
N.A.
N.A.
N.A.
0
6.6
P-Site Similarity:
100
100
100
86.6
N.A.
86.6
86.6
N.A.
46.6
33.3
13.3
20
N.A.
N.A.
N.A.
13.3
40
Percent
Protein Identity:
N.A.
27.8
N.A.
27
N.A.
N.A.
Protein Similarity:
N.A.
42.5
N.A.
43.2
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
0
0
0
0
0
0
0
8
0
0
43
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
8
8
0
0
0
15
0
0
22
0
15
0
8
0
8
% D
% Glu:
8
0
15
0
8
8
22
0
0
0
8
0
0
0
8
% E
% Phe:
0
0
0
8
0
0
8
0
0
8
0
65
8
0
8
% F
% Gly:
0
8
0
0
0
0
0
0
0
8
0
0
0
8
8
% G
% His:
0
0
0
0
15
0
8
15
8
36
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
8
8
0
8
8
0
8
0
% I
% Lys:
15
0
22
15
0
8
36
22
15
8
0
0
8
50
0
% K
% Leu:
8
0
0
0
50
8
0
8
0
8
0
8
8
8
0
% L
% Met:
0
15
8
0
8
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
22
8
29
15
0
0
0
8
29
8
36
8
0
0
0
% N
% Pro:
0
8
0
0
0
0
0
0
0
8
0
0
0
0
0
% P
% Gln:
0
0
8
8
0
0
8
0
0
8
0
8
8
0
8
% Q
% Arg:
0
0
0
43
0
0
0
0
8
0
22
0
0
0
0
% R
% Ser:
0
50
8
0
0
0
15
0
0
8
0
0
8
22
8
% S
% Thr:
0
0
0
0
0
0
8
0
8
0
8
0
8
0
8
% T
% Val:
0
0
0
0
22
15
0
8
0
0
8
0
50
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
43
8
8
8
0
50
0
29
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _