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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSC
All Species:
25.45
Human Site:
Y190
Identified Species:
43.08
UniProt:
P53634
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53634
NP_001805.3
463
51842
Y190
K
S
W
T
A
T
T
Y
M
E
Y
E
T
L
T
Chimpanzee
Pan troglodytes
XP_508684
463
51907
Y190
K
S
W
T
A
T
T
Y
M
E
Y
E
T
L
T
Rhesus Macaque
Macaca mulatta
XP_001104734
463
51874
Y190
K
S
W
T
A
T
T
Y
M
E
Y
E
T
L
T
Dog
Lupus familis
XP_535784
481
54085
Y211
K
S
W
T
A
T
R
Y
I
E
Y
E
T
L
T
Cat
Felis silvestris
Mouse
Mus musculus
P97821
462
52358
Y190
K
S
W
T
A
T
A
Y
K
E
Y
E
K
M
S
Rat
Rattus norvegicus
P80067
462
52217
Y190
K
S
W
T
A
T
T
Y
E
E
Y
E
K
L
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512140
469
52438
Y196
K
A
W
K
A
T
T
Y
E
E
Y
E
T
L
T
Chicken
Gallus gallus
P43233
340
37569
M78
R
V
D
F
A
E
D
M
D
L
P
D
T
F
D
Frog
Xenopus laevis
NP_001080511
458
51565
G191
S
V
Y
P
E
Y
E
G
M
S
I
E
D
L
V
Zebra Danio
Brachydanio rerio
NP_999887
455
50596
I191
S
F
H
E
T
L
S
I
H
E
M
L
R
R
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P43510
379
42386
K117
D
S
R
D
N
W
P
K
C
D
S
I
K
V
I
Sea Urchin
Strong. purpuratus
XP_001201161
459
51309
T193
Y
P
E
H
E
M
Y
T
V
E
D
M
R
R
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q10717
360
39181
L98
R
S
T
N
R
K
G
L
S
Y
R
L
G
I
N
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H166
358
38941
K96
L
I
R
S
T
N
K
K
G
L
S
Y
K
L
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
95.6
79
N.A.
77.7
78.6
N.A.
72
22.8
62.4
63.2
N.A.
N.A.
N.A.
23.3
54.8
Protein Similarity:
100
99.7
97.4
85.4
N.A.
86.6
87
N.A.
83.5
38
77.3
77.1
N.A.
N.A.
N.A.
38.2
71.4
P-Site Identity:
100
100
100
86.6
N.A.
66.6
80
N.A.
80
13.3
20
6.6
N.A.
N.A.
N.A.
6.6
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
80
86.6
N.A.
86.6
26.6
26.6
20
N.A.
N.A.
N.A.
20
13.3
Percent
Protein Identity:
N.A.
27.8
N.A.
27
N.A.
N.A.
Protein Similarity:
N.A.
42.5
N.A.
43.2
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
20
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
58
0
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
8
0
8
8
0
0
8
0
8
8
8
8
8
0
8
% D
% Glu:
0
0
8
8
15
8
8
0
15
65
0
58
0
0
0
% E
% Phe:
0
8
0
8
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
0
0
0
0
0
8
8
8
0
0
0
8
0
8
% G
% His:
0
0
8
8
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
0
8
0
0
0
0
0
8
8
0
8
8
0
8
8
% I
% Lys:
50
0
0
8
0
8
8
15
8
0
0
0
29
0
0
% K
% Leu:
8
0
0
0
0
8
0
8
0
15
0
15
0
58
0
% L
% Met:
0
0
0
0
0
8
0
8
29
0
8
8
0
8
0
% M
% Asn:
0
0
0
8
8
8
0
0
0
0
0
0
0
0
8
% N
% Pro:
0
8
0
8
0
0
8
0
0
0
8
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
15
0
15
0
8
0
8
0
0
0
8
0
15
15
8
% R
% Ser:
15
58
0
8
0
0
8
0
8
8
15
0
0
0
22
% S
% Thr:
0
0
8
43
15
50
36
8
0
0
0
0
43
0
36
% T
% Val:
0
15
0
0
0
0
0
0
8
0
0
0
0
8
8
% V
% Trp:
0
0
50
0
0
8
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
8
0
0
8
8
50
0
8
50
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _