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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSC
All Species:
16.97
Human Site:
Y345
Identified Species:
28.72
UniProt:
P53634
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53634
NP_001805.3
463
51842
Y345
F
R
Y
Y
S
S
E
Y
H
Y
V
G
G
F
Y
Chimpanzee
Pan troglodytes
XP_508684
463
51907
Y345
F
R
Y
Y
S
S
E
Y
H
Y
V
G
G
F
Y
Rhesus Macaque
Macaca mulatta
XP_001104734
463
51874
Y345
F
R
Y
Y
S
S
E
Y
H
Y
V
G
G
F
Y
Dog
Lupus familis
XP_535784
481
54085
V366
Y
S
S
E
Y
H
Y
V
G
G
F
Y
G
A
C
Cat
Felis silvestris
Mouse
Mus musculus
P97821
462
52358
Y345
R
Y
Y
S
S
D
Y
Y
Y
V
G
G
F
Y
G
Rat
Rattus norvegicus
P80067
462
52217
Y345
R
Y
Y
S
S
E
Y
Y
Y
V
G
G
F
Y
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512140
469
52438
Y351
P
R
Y
Y
A
S
D
Y
Q
Y
V
G
G
F
Y
Chicken
Gallus gallus
P43233
340
37569
V233
Y
G
I
T
S
Y
G
V
P
R
S
E
K
E
I
Frog
Xenopus laevis
NP_001080511
458
51565
F346
E
Y
H
Y
V
G
G
F
Y
G
G
C
N
E
A
Zebra Danio
Brachydanio rerio
NP_999887
455
50596
G346
Y
V
G
G
F
Y
G
G
C
S
E
S
A
M
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P43510
379
42386
T272
A
I
Q
K
E
L
M
T
H
G
P
L
E
I
A
Sea Urchin
Strong. purpuratus
XP_001201161
459
51309
G348
Y
V
G
G
F
Y
G
G
C
K
E
E
L
M
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q10717
360
39181
D253
N
V
G
V
K
V
L
D
S
V
N
I
T
L
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H166
358
38941
N251
N
V
G
V
Q
V
L
N
S
V
N
I
T
L
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
95.6
79
N.A.
77.7
78.6
N.A.
72
22.8
62.4
63.2
N.A.
N.A.
N.A.
23.3
54.8
Protein Similarity:
100
99.7
97.4
85.4
N.A.
86.6
87
N.A.
83.5
38
77.3
77.1
N.A.
N.A.
N.A.
38.2
71.4
P-Site Identity:
100
100
100
6.6
N.A.
26.6
26.6
N.A.
73.3
6.6
6.6
0
N.A.
N.A.
N.A.
6.6
0
P-Site Similarity:
100
100
100
13.3
N.A.
40
40
N.A.
86.6
13.3
26.6
6.6
N.A.
N.A.
N.A.
6.6
6.6
Percent
Protein Identity:
N.A.
27.8
N.A.
27
N.A.
N.A.
Protein Similarity:
N.A.
42.5
N.A.
43.2
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
0
N.A.
0
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
0
0
0
0
0
0
0
8
8
15
% A
% Cys:
0
0
0
0
0
0
0
0
15
0
0
8
0
0
8
% C
% Asp:
0
0
0
0
0
8
8
8
0
0
0
0
0
0
0
% D
% Glu:
8
0
0
8
8
8
22
0
0
0
15
15
8
15
0
% E
% Phe:
22
0
0
0
15
0
0
8
0
0
8
0
15
29
0
% F
% Gly:
0
8
29
15
0
8
29
15
8
22
22
43
36
0
29
% G
% His:
0
0
8
0
0
8
0
0
29
0
0
0
0
0
0
% H
% Ile:
0
8
8
0
0
0
0
0
0
0
0
15
0
8
8
% I
% Lys:
0
0
0
8
8
0
0
0
0
8
0
0
8
0
0
% K
% Leu:
0
0
0
0
0
8
15
0
0
0
0
8
8
15
0
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
0
15
8
% M
% Asn:
15
0
0
0
0
0
0
8
0
0
15
0
8
0
0
% N
% Pro:
8
0
0
0
0
0
0
0
8
0
8
0
0
0
0
% P
% Gln:
0
0
8
0
8
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
15
29
0
0
0
0
0
0
0
8
0
0
0
0
8
% R
% Ser:
0
8
8
15
43
29
0
0
15
8
8
8
0
0
0
% S
% Thr:
0
0
0
8
0
0
0
8
0
0
0
0
15
0
0
% T
% Val:
0
29
0
15
8
15
0
15
0
29
29
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
29
22
43
36
8
22
22
43
22
29
0
8
0
15
29
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _