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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTSC
All Species:
32.73
Human Site:
Y422
Identified Species:
55.38
UniProt:
P53634
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53634
NP_001805.3
463
51842
Y422
D
S
A
S
G
M
D
Y
W
I
V
K
N
S
W
Chimpanzee
Pan troglodytes
XP_508684
463
51907
Y422
D
S
A
S
G
M
D
Y
W
I
V
K
N
S
W
Rhesus Macaque
Macaca mulatta
XP_001104734
463
51874
Y422
D
S
A
S
G
M
D
Y
W
I
V
K
N
S
W
Dog
Lupus familis
XP_535784
481
54085
Y440
D
S
A
S
G
M
D
Y
W
I
V
K
N
S
W
Cat
Felis silvestris
Mouse
Mus musculus
P97821
462
52358
Y421
D
P
V
T
G
I
E
Y
W
I
I
K
N
S
W
Rat
Rattus norvegicus
P80067
462
52217
Y421
D
P
V
T
G
L
D
Y
W
I
V
K
N
S
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512140
469
52438
Y428
D
P
A
T
G
L
D
Y
W
I
V
K
N
S
W
Chicken
Gallus gallus
P43233
340
37569
S300
P
Y
W
L
A
A
N
S
W
N
T
D
W
G
I
Frog
Xenopus laevis
NP_001080511
458
51565
Y417
D
Q
Q
T
G
E
K
Y
W
I
V
K
N
S
W
Zebra Danio
Brachydanio rerio
NP_999887
455
50596
Y414
C
H
K
T
G
E
K
Y
W
I
V
K
N
S
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P43510
379
42386
I339
G
E
D
G
F
F
R
I
L
R
G
V
D
E
C
Sea Urchin
Strong. purpuratus
XP_001201161
459
51309
F419
E
A
G
S
G
E
K
F
W
I
V
K
N
S
W
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q10717
360
39181
V320
G
Y
G
V
E
D
G
V
P
Y
W
L
I
K
N
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8H166
358
38941
V318
G
Y
G
V
E
D
G
V
P
Y
W
L
I
K
N
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
95.6
79
N.A.
77.7
78.6
N.A.
72
22.8
62.4
63.2
N.A.
N.A.
N.A.
23.3
54.8
Protein Similarity:
100
99.7
97.4
85.4
N.A.
86.6
87
N.A.
83.5
38
77.3
77.1
N.A.
N.A.
N.A.
38.2
71.4
P-Site Identity:
100
100
100
100
N.A.
60
73.3
N.A.
80
6.6
66.6
60
N.A.
N.A.
N.A.
0
60
P-Site Similarity:
100
100
100
100
N.A.
86.6
86.6
N.A.
93.3
13.3
73.3
66.6
N.A.
N.A.
N.A.
6.6
80
Percent
Protein Identity:
N.A.
27.8
N.A.
27
N.A.
N.A.
Protein Similarity:
N.A.
42.5
N.A.
43.2
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
0
N.A.
0
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
36
0
8
8
0
0
0
0
0
0
0
0
0
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
58
0
8
0
0
15
43
0
0
0
0
8
8
0
0
% D
% Glu:
8
8
0
0
15
22
8
0
0
0
0
0
0
8
0
% E
% Phe:
0
0
0
0
8
8
0
8
0
0
0
0
0
0
0
% F
% Gly:
22
0
22
8
72
0
15
0
0
0
8
0
0
8
0
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
0
8
0
72
8
0
15
0
8
% I
% Lys:
0
0
8
0
0
0
22
0
0
0
0
72
0
15
0
% K
% Leu:
0
0
0
8
0
15
0
0
8
0
0
15
0
0
0
% L
% Met:
0
0
0
0
0
29
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
8
0
0
72
0
15
% N
% Pro:
8
22
0
0
0
0
0
0
15
0
0
0
0
0
0
% P
% Gln:
0
8
8
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% R
% Ser:
0
29
0
36
0
0
0
8
0
0
0
0
0
72
0
% S
% Thr:
0
0
0
36
0
0
0
0
0
0
8
0
0
0
0
% T
% Val:
0
0
15
15
0
0
0
15
0
0
65
8
0
0
0
% V
% Trp:
0
0
8
0
0
0
0
0
79
0
15
0
8
0
72
% W
% Tyr:
0
22
0
0
0
0
0
65
0
15
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _