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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AP2S1
All Species:
21.36
Human Site:
S140
Identified Species:
47
UniProt:
P53680
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53680
NP_004060.2
142
17018
S140
K
Q
L
L
M
L
Q
S
L
E
_
_
_
_
_
Chimpanzee
Pan troglodytes
XP_001168470
158
18910
S156
K
Q
L
L
M
L
Q
S
L
E
_
_
_
_
_
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q9DB50
160
18911
L139
K
A
I
E
Q
A
D
L
L
Q
E
D
A
K
E
Rat
Rattus norvegicus
P62744
142
16999
S140
K
Q
L
L
M
L
Q
S
L
E
_
_
_
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_998320
142
16986
S140
K
Q
L
L
M
L
Q
S
L
E
_
_
_
_
_
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650961
142
16945
S140
K
Q
L
L
T
L
N
S
L
E
_
_
_
_
_
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_508767
142
17064
S140
K
Q
L
L
M
L
T
S
L
E
_
_
_
_
_
Sea Urchin
Strong. purpuratus
XP_786054
142
16829
Q140
K
Q
L
M
A
L
G
Q
L
E
_
_
_
_
_
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O50016
132
15996
K130
G
E
L
Q
E
T
S
K
R
Q
_
_
_
_
_
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q00381
147
17355
R145
E
R
L
S
I
L
D
R
L
D
_
_
_
_
_
Red Bread Mold
Neurospora crassa
Q7SAQ1
143
16937
K141
T
R
L
E
H
L
D
K
L
E
_
_
_
_
_
Conservation
Percent
Protein Identity:
100
89.8
N.A.
N.A.
N.A.
43.7
100
N.A.
N.A.
N.A.
N.A.
99.3
N.A.
95.7
N.A.
95
92.2
Protein Similarity:
100
89.8
N.A.
N.A.
N.A.
62.5
100
N.A.
N.A.
N.A.
N.A.
99.3
N.A.
97.1
N.A.
96.4
96.4
P-Site Identity:
100
100
N.A.
N.A.
N.A.
13.3
100
N.A.
N.A.
N.A.
N.A.
100
N.A.
80
N.A.
90
60
P-Site Similarity:
100
100
N.A.
N.A.
N.A.
26.6
100
N.A.
N.A.
N.A.
N.A.
100
N.A.
80
N.A.
90
70
Percent
Protein Identity:
N.A.
61.9
N.A.
N.A.
48.9
67.8
Protein Similarity:
N.A.
74.6
N.A.
N.A.
71.4
79.7
P-Site Identity:
N.A.
10
N.A.
N.A.
30
40
P-Site Similarity:
N.A.
30
N.A.
N.A.
70
50
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
10
10
0
0
0
0
0
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
28
0
0
10
0
10
0
0
0
% D
% Glu:
10
10
0
19
10
0
0
0
0
73
10
0
0
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
10
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
73
0
0
0
0
0
0
19
0
0
0
0
0
10
0
% K
% Leu:
0
0
91
55
0
82
0
10
91
0
0
0
0
0
0
% L
% Met:
0
0
0
10
46
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
64
0
10
10
0
37
10
0
19
0
0
0
0
0
% Q
% Arg:
0
19
0
0
0
0
0
10
10
0
0
0
0
0
0
% R
% Ser:
0
0
0
10
0
0
10
55
0
0
0
0
0
0
0
% S
% Thr:
10
0
0
0
10
10
10
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
91
91
91
91
91
% _