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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HCCS
All Species:
33.94
Human Site:
S253
Identified Species:
49.78
UniProt:
P53701
Number Species:
15
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53701
NP_001116080.1
268
30602
S253
R
P
A
L
D
S
L
S
A
V
W
D
R
M
K
Chimpanzee
Pan troglodytes
XP_001142842
269
30427
S254
R
P
A
L
D
S
L
S
A
V
W
D
R
M
K
Rhesus Macaque
Macaca mulatta
XP_001094078
268
30718
S253
R
P
A
L
D
S
L
S
A
V
W
D
R
M
K
Dog
Lupus familis
XP_537950
272
31050
S257
R
P
A
L
D
S
F
S
A
V
W
D
R
M
K
Cat
Felis silvestris
Mouse
Mus musculus
P53702
272
30989
S257
R
P
A
F
D
S
F
S
A
V
W
D
R
M
K
Rat
Rattus norvegicus
XP_228867
274
31111
S259
R
P
A
F
D
S
F
S
A
V
W
D
R
M
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506165
272
30773
T257
R
P
A
F
D
S
L
T
A
V
W
D
R
M
K
Chicken
Gallus gallus
Q5F339
273
31420
S258
R
P
A
F
D
S
L
S
A
V
W
D
R
M
K
Frog
Xenopus laevis
NP_001087149
267
30990
S252
R
P
A
F
D
S
M
S
A
I
W
D
R
M
K
Zebra Danio
Brachydanio rerio
NP_958859
269
30882
Q254
R
P
A
F
D
S
M
Q
A
V
W
D
R
M
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651003
281
32005
D247
R
P
A
M
D
S
V
D
N
V
W
D
R
M
R
Honey Bee
Apis mellifera
XP_392497
276
32212
E244
R
P
A
M
D
S
L
E
N
I
W
D
R
M
R
Nematode Worm
Caenorhab. elegans
P53703
280
31245
G244
R
P
A
V
N
D
I
G
N
I
W
D
R
M
V
Sea Urchin
Strong. purpuratus
XP_788812
293
32619
G276
R
P
A
F
D
S
P
G
A
T
W
D
R
M
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P06182
269
30062
D245
R
P
A
L
D
S
L
D
N
A
K
D
R
M
T
Red Bread Mold
Neurospora crassa
P14187
346
38128
G318
R
P
A
V
T
V
T
G
A
C
E
R
L
L
R
Conservation
Percent
Protein Identity:
100
89.2
98.1
91.1
N.A.
82.7
86.1
N.A.
77.9
75.8
69
68.7
N.A.
52.6
53.9
48.5
56.6
Protein Similarity:
100
92.5
98.8
93.7
N.A.
89.3
90.5
N.A.
88.5
86
83.5
81
N.A.
68.3
66.3
62.1
68.9
P-Site Identity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
86.6
93.3
80
80
N.A.
66.6
66.6
46.6
73.3
P-Site Similarity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
93.3
93.3
93.3
86.6
N.A.
86.6
86.6
73.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
36.4
32
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
52.4
43.9
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
66.6
26.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
66.6
46.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
100
0
0
0
0
0
75
7
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% C
% Asp:
0
0
0
0
88
7
0
13
0
0
0
94
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
7
0
0
7
0
0
0
0
% E
% Phe:
0
0
0
44
0
0
19
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
19
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
7
0
0
19
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
69
% K
% Leu:
0
0
0
32
0
0
44
0
0
0
0
0
7
7
0
% L
% Met:
0
0
0
13
0
0
13
0
0
0
0
0
0
94
0
% M
% Asn:
0
0
0
0
7
0
0
0
25
0
0
0
0
0
0
% N
% Pro:
0
100
0
0
0
0
7
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% Q
% Arg:
100
0
0
0
0
0
0
0
0
0
0
7
94
0
19
% R
% Ser:
0
0
0
0
0
88
0
50
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
7
0
7
7
0
7
0
0
0
0
7
% T
% Val:
0
0
0
13
0
7
7
0
0
63
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
88
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _