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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: KIAA0174 All Species: 16.97
Human Site: S238 Identified Species: 31.11
UniProt: P53990 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P53990 NP_055576.2 364 39751 S238 P M P M P M P S A N T P F S Y
Chimpanzee Pan troglodytes XP_001151193 502 54591 S376 P M P M P M P S A N T P F S Y
Rhesus Macaque Macaca mulatta XP_001105424 362 39442 S236 P M P M P M P S A N T P F S Y
Dog Lupus familis XP_536798 366 39902 S240 P M P M P M P S P S T P F S Y
Cat Felis silvestris
Mouse Mus musculus Q9CX00 362 39450 M236 P M P M P M P M P S P N A P F
Rat Rattus norvegicus Q568Z6 366 39923 M238 P M P M P M P M P S P S P N A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_414234 366 39721 M238 P V P M P M P M P S T N P P F
Frog Xenopus laevis NP_001086654 354 38586 T227 V A A M Q M P T P T I P F A Y
Zebra Danio Brachydanio rerio NP_997750 354 38941 M228 A M G M P M P M P M P M P M P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648058 417 45626 S239 P D M P M P P S A K P F N Y P
Honey Bee Apis mellifera XP_001122854 352 39998 P226 F I G F P Q P P L L P N P N S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786445 370 40218 A238 P P Q P Q P Q A Q A Q A P T P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53843 298 34477 L173 E E L V D L Y L K E I A K T Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 72.3 97.8 96.7 N.A. 95 94.8 N.A. N.A. 87.6 73.9 72.2 N.A. 47.7 47.7 N.A. 48.1
Protein Similarity: 100 72.3 98.9 97.5 N.A. 96.4 96.4 N.A. N.A. 91.8 78.5 76.6 N.A. 59.4 62 N.A. 62.1
P-Site Identity: 100 100 100 86.6 N.A. 46.6 46.6 N.A. N.A. 46.6 40 33.3 N.A. 26.6 13.3 N.A. 6.6
P-Site Similarity: 100 100 100 93.3 N.A. 60 60 N.A. N.A. 66.6 53.3 33.3 N.A. 26.6 26.6 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 45.3 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 8 0 0 0 0 8 31 8 0 16 8 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 8 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 8 8 0 0 0 0 0 0 0 8 0 0 0 0 0 % E
% Phe: 8 0 0 8 0 0 0 0 0 0 0 8 39 0 16 % F
% Gly: 0 0 16 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 0 0 16 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 8 8 0 0 8 0 0 % K
% Leu: 0 0 8 0 0 8 0 8 8 8 0 0 0 0 0 % L
% Met: 0 54 8 70 8 70 0 31 0 8 0 8 0 8 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 24 0 24 8 16 0 % N
% Pro: 70 8 54 16 70 16 85 8 47 0 39 39 39 16 24 % P
% Gln: 0 0 8 0 16 8 8 0 8 0 8 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 39 0 31 0 8 0 31 8 % S
% Thr: 0 0 0 0 0 0 0 8 0 8 39 0 0 16 0 % T
% Val: 8 8 0 8 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 8 0 0 0 0 0 0 8 47 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _