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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SEC24C All Species: 13.03
Human Site: S218 Identified Species: 20.48
UniProt: P53992 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P53992 NP_004913.2 1094 118325 S218 S S F T P P A S G G P R L P S
Chimpanzee Pan troglodytes XP_001145058 1094 118246 S218 S S F T P P A S G G P R L P S
Rhesus Macaque Macaca mulatta XP_001104565 998 107625 P189 Y P Q G Q A P P L S Q A Q G H
Dog Lupus familis XP_850963 1096 118584 S219 S T F T S P A S G G P R M P S
Cat Felis silvestris
Mouse Mus musculus Q3U2P1 1090 118764 G221 G G P P P S R G P A P Q K T P
Rat Rattus norvegicus NP_001102926 1095 118506 S218 S S F T S P A S G G P R M P S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513100 1030 112379 P219 L P G Q A A G P G Y P P Q H A
Chicken Gallus gallus XP_421617 1147 124543 G275 S S Y P P P T G A P R P P P M
Frog Xenopus laevis NP_001087832 1126 123503 L218 S G P P P Q N L P S S Q A P G
Zebra Danio Brachydanio rerio XP_700597 1315 142554 P218 A A Y T P S A P P T F P P T S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392952 1276 140829 L328 P S L S T P S L S G Q H Y S S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783728 1150 123558 R261 S N T N Y G A R P T N T S Y G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M081 1080 116273 P227 Q A P Y V R P P S A P Y A R T
Baker's Yeast Sacchar. cerevisiae P53953 876 98925 V67 Q F P G S G K V V N Q L Y P V
Red Bread Mold Neurospora crassa Q7S4P3 950 103512 A141 S Q G V P P A A V G P A P G G
Conservation
Percent
Protein Identity: 100 99.5 86.9 94.8 N.A. 26.9 92 N.A. 51.9 75.4 69 59.5 N.A. N.A. 44.5 N.A. 52.6
Protein Similarity: 100 99.7 87.9 96.1 N.A. 45.8 94.4 N.A. 66.2 82.3 78.1 69 N.A. N.A. 59.4 N.A. 64.3
P-Site Identity: 100 100 0 80 N.A. 13.3 86.6 N.A. 13.3 33.3 20 26.6 N.A. N.A. 26.6 N.A. 13.3
P-Site Similarity: 100 100 0 93.3 N.A. 20 93.3 N.A. 20 40 26.6 46.6 N.A. N.A. 40 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 33 22.4 30
Protein Similarity: N.A. N.A. N.A. 49.3 41.1 47
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 40
P-Site Similarity: N.A. N.A. N.A. 20 6.6 46.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 14 0 0 7 14 47 7 7 14 0 14 14 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 7 27 0 0 0 0 0 0 0 7 0 0 0 0 % F
% Gly: 7 14 14 14 0 14 7 14 34 40 0 0 0 14 20 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 7 0 7 7 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 7 0 0 0 0 0 7 0 0 % K
% Leu: 7 0 7 0 0 0 0 14 7 0 0 7 14 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 14 0 7 % M
% Asn: 0 7 0 7 0 0 7 0 0 7 7 0 0 0 0 % N
% Pro: 7 14 27 20 47 47 14 27 27 7 54 20 20 47 7 % P
% Gln: 14 7 7 7 7 7 0 0 0 0 20 14 14 0 0 % Q
% Arg: 0 0 0 0 0 7 7 7 0 0 7 27 0 7 0 % R
% Ser: 54 34 0 7 20 14 7 27 14 14 7 0 7 7 40 % S
% Thr: 0 7 7 34 7 0 7 0 0 14 0 7 0 14 7 % T
% Val: 0 0 0 7 7 0 0 7 14 0 0 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 14 7 7 0 0 0 0 7 0 7 14 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _