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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SEC24C All Species: 16.06
Human Site: S225 Identified Species: 25.24
UniProt: P53992 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P53992 NP_004913.2 1094 118325 S225 S G G P R L P S M T G P L L P
Chimpanzee Pan troglodytes XP_001145058 1094 118246 S225 S G G P R L P S M T G P L L P
Rhesus Macaque Macaca mulatta XP_001104565 998 107625 H196 P L S Q A Q G H P G I Q T P Q
Dog Lupus familis XP_850963 1096 118584 S226 S G G P R M P S M T G P F L P
Cat Felis silvestris
Mouse Mus musculus Q3U2P1 1090 118764 P228 G P A P Q K T P P R A A P P P
Rat Rattus norvegicus NP_001102926 1095 118506 S225 S G G P R M P S M P G P L P P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513100 1030 112379 A226 P G Y P P Q H A T N Y G P Q M
Chicken Gallus gallus XP_421617 1147 124543 M282 G A P R P P P M P G P P L S G
Frog Xenopus laevis NP_001087832 1126 123503 G225 L P S S Q A P G F P P P P S A
Zebra Danio Brachydanio rerio XP_700597 1315 142554 S225 P P T F P P T S S A P S Q P P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392952 1276 140829 S335 L S G Q H Y S S L Q G H Q K P
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783728 1150 123558 G268 R P T N T S Y G Q P G T A G P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M081 1080 116273 T234 P S A P Y A R T P P Q P L G S
Baker's Yeast Sacchar. cerevisiae P53953 876 98925 V74 V V N Q L Y P V D L F T E L P
Red Bread Mold Neurospora crassa Q7S4P3 950 103512 G148 A V G P A P G G V A G I T A G
Conservation
Percent
Protein Identity: 100 99.5 86.9 94.8 N.A. 26.9 92 N.A. 51.9 75.4 69 59.5 N.A. N.A. 44.5 N.A. 52.6
Protein Similarity: 100 99.7 87.9 96.1 N.A. 45.8 94.4 N.A. 66.2 82.3 78.1 69 N.A. N.A. 59.4 N.A. 64.3
P-Site Identity: 100 100 0 86.6 N.A. 13.3 80 N.A. 13.3 20 13.3 13.3 N.A. N.A. 26.6 N.A. 13.3
P-Site Similarity: 100 100 0 93.3 N.A. 20 86.6 N.A. 20 20 20 13.3 N.A. N.A. 33.3 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. 33 22.4 30
Protein Similarity: N.A. N.A. N.A. 49.3 41.1 47
P-Site Identity: N.A. N.A. N.A. 20 20 20
P-Site Similarity: N.A. N.A. N.A. 26.6 20 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 14 0 14 14 0 7 0 14 7 7 7 7 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % E
% Phe: 0 0 0 7 0 0 0 0 7 0 7 0 7 0 0 % F
% Gly: 14 34 40 0 0 0 14 20 0 14 47 7 0 14 14 % G
% His: 0 0 0 0 7 0 7 7 0 0 0 7 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 7 7 0 0 0 % I
% Lys: 0 0 0 0 0 7 0 0 0 0 0 0 0 7 0 % K
% Leu: 14 7 0 0 7 14 0 0 7 7 0 0 34 27 0 % L
% Met: 0 0 0 0 0 14 0 7 27 0 0 0 0 0 7 % M
% Asn: 0 0 7 7 0 0 0 0 0 7 0 0 0 0 0 % N
% Pro: 27 27 7 54 20 20 47 7 27 27 20 47 20 27 60 % P
% Gln: 0 0 0 20 14 14 0 0 7 7 7 7 14 7 7 % Q
% Arg: 7 0 0 7 27 0 7 0 0 7 0 0 0 0 0 % R
% Ser: 27 14 14 7 0 7 7 40 7 0 0 7 0 14 7 % S
% Thr: 0 0 14 0 7 0 14 7 7 20 0 14 14 0 0 % T
% Val: 7 14 0 0 0 0 0 7 7 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 7 0 7 14 7 0 0 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _