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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLG All Species: 9.09
Human Site: S33 Identified Species: 16.67
UniProt: P54098 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54098 NP_001119603.1 1239 139562 S33 V S S S V P A S D P S D G Q R
Chimpanzee Pan troglodytes XP_523149 1236 139116 S33 V S S S V P A S D P S D G Q R
Rhesus Macaque Macaca mulatta XP_001092360 1228 138042 S33 V S S S V P A S D P S D G R R
Dog Lupus familis XP_545850 1234 138197 P34 V S S S G P A P V P S D G P P
Cat Felis silvestris
Mouse Mus musculus P54099 1239 138880 P33 V A S S V L D P V P S D G R P
Rat Rattus norvegicus Q9QYV8 1216 136837 P33 V S S S V L D P V P S D G Q P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q92076 647 72836
Frog Xenopus laevis Q91684 1200 137225 A33 S Y A P Q L H A K P L E M E T
Zebra Danio Brachydanio rerio XP_001921328 1203 137518 Q33 S V K S K P Q Q G S D Q T R L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q27607 1145 129809 E42 V N K P K K P E N V E N G P T
Honey Bee Apis mellifera XP_395230 1086 125181 M29 I N E I N I Q M L P K S L H K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P15801 1254 143484 K33 A R W F S T K K N T A E A P R
Red Bread Mold Neurospora crassa Q9Y767 1456 161685 Q34 L F S R Y P R Q L G H L R W D
Conservation
Percent
Protein Identity: 100 99.1 96.4 87.8 N.A. 85.4 85.6 N.A. N.A. 41.6 64.8 67.1 N.A. 42.7 39.7 N.A. N.A.
Protein Similarity: 100 99.3 97.3 91.1 N.A. 89.5 90.3 N.A. N.A. 47 77 77.6 N.A. 57.8 57.7 N.A. N.A.
P-Site Identity: 100 100 93.3 66.6 N.A. 53.3 66.6 N.A. N.A. 0 6.6 13.3 N.A. 13.3 6.6 N.A. N.A.
P-Site Similarity: 100 100 100 66.6 N.A. 66.6 66.6 N.A. N.A. 0 33.3 20 N.A. 33.3 26.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20.3 21.4
Protein Similarity: N.A. N.A. N.A. N.A. 38.3 38.2
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 8 0 0 0 31 8 0 0 8 0 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 16 0 24 0 8 47 0 0 8 % D
% Glu: 0 0 8 0 0 0 0 8 0 0 8 16 0 8 0 % E
% Phe: 0 8 0 8 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 8 0 0 0 8 8 0 0 54 0 0 % G
% His: 0 0 0 0 0 0 8 0 0 0 8 0 0 8 0 % H
% Ile: 8 0 0 8 0 8 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 16 0 16 8 8 8 8 0 8 0 0 0 8 % K
% Leu: 8 0 0 0 0 24 0 0 16 0 8 8 8 0 8 % L
% Met: 0 0 0 0 0 0 0 8 0 0 0 0 8 0 0 % M
% Asn: 0 16 0 0 8 0 0 0 16 0 0 8 0 0 0 % N
% Pro: 0 0 0 16 0 47 8 24 0 62 0 0 0 24 24 % P
% Gln: 0 0 0 0 8 0 16 16 0 0 0 8 0 24 0 % Q
% Arg: 0 8 0 8 0 0 8 0 0 0 0 0 8 24 31 % R
% Ser: 16 39 54 54 8 0 0 24 0 8 47 8 0 0 0 % S
% Thr: 0 0 0 0 0 8 0 0 0 8 0 0 8 0 16 % T
% Val: 54 8 0 0 39 0 0 0 24 8 0 0 0 0 0 % V
% Trp: 0 0 8 0 0 0 0 0 0 0 0 0 0 8 0 % W
% Tyr: 0 8 0 0 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _