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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLG All Species: 30.3
Human Site: S998 Identified Species: 55.56
UniProt: P54098 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54098 NP_001119603.1 1239 139562 S998 G L R W Y R L S D E G E W L V
Chimpanzee Pan troglodytes XP_523149 1236 139116 S995 G L R W Y R L S D E G E W L V
Rhesus Macaque Macaca mulatta XP_001092360 1228 138042 S987 G L R W Y R L S D E G E W L V
Dog Lupus familis XP_545850 1234 138197 S999 G L R R Y R L S E E G E W L V
Cat Felis silvestris
Mouse Mus musculus P54099 1239 138880 S977 G L R R Y R L S A D G E W L V
Rat Rattus norvegicus Q9QYV8 1216 136837 S975 G L R R Y R L S D D G E W L V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q92076 647 72836 L420 G E W L V K E L E L A V D K A
Frog Xenopus laevis Q91684 1200 137225 S968 G I R R Y I L S K E G E W L V
Zebra Danio Brachydanio rerio XP_001921328 1203 137518 S959 G L R R Y H L S E E G E W L L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q27607 1145 129809 V912 S I T K G K R V Y R L R E E F
Honey Bee Apis mellifera XP_395230 1086 125181 K859 T K G K K I Y K L K P E Y I N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P15801 1254 143484 Y1000 V S Q Y A Y N Y R E P V F E E
Red Bread Mold Neurospora crassa Q9Y767 1456 161685 R1062 V P V M Q R L R E R A E A G D
Conservation
Percent
Protein Identity: 100 99.1 96.4 87.8 N.A. 85.4 85.6 N.A. N.A. 41.6 64.8 67.1 N.A. 42.7 39.7 N.A. N.A.
Protein Similarity: 100 99.3 97.3 91.1 N.A. 89.5 90.3 N.A. N.A. 47 77 77.6 N.A. 57.8 57.7 N.A. N.A.
P-Site Identity: 100 100 100 86.6 N.A. 80 86.6 N.A. N.A. 6.6 73.3 73.3 N.A. 0 6.6 N.A. N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 86.6 93.3 N.A. N.A. 20 80 86.6 N.A. 13.3 26.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20.3 21.4
Protein Similarity: N.A. N.A. N.A. N.A. 38.3 38.2
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 20
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 0 0 0 8 0 16 0 8 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 31 16 0 0 8 0 8 % D
% Glu: 0 8 0 0 0 0 8 0 31 54 0 77 8 16 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 8 % F
% Gly: 70 0 8 0 8 0 0 0 0 0 62 0 0 8 0 % G
% His: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 16 0 0 0 16 0 0 0 0 0 0 0 8 0 % I
% Lys: 0 8 0 16 8 16 0 8 8 8 0 0 0 8 0 % K
% Leu: 0 54 0 8 0 0 70 8 8 8 8 0 0 62 8 % L
% Met: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 8 % N
% Pro: 0 8 0 0 0 0 0 0 0 0 16 0 0 0 0 % P
% Gln: 0 0 8 0 8 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 62 39 0 54 8 8 8 16 0 8 0 0 0 % R
% Ser: 8 8 0 0 0 0 0 62 0 0 0 0 0 0 0 % S
% Thr: 8 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 16 0 8 0 8 0 0 8 0 0 0 16 0 0 54 % V
% Trp: 0 0 8 24 0 0 0 0 0 0 0 0 62 0 0 % W
% Tyr: 0 0 0 8 62 8 8 8 8 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _