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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HIRA All Species: 32.12
Human Site: S494 Identified Species: 44.17
UniProt: P54198 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54198 NP_003316.3 1017 111835 S494 S L A G T M L S S H S S P Q L
Chimpanzee Pan troglodytes XP_001165585 1017 111787 S494 S L A G T M L S S H S S P Q L
Rhesus Macaque Macaca mulatta XP_001112873 1138 124408 S615 S L A G T M L S S H S S P Q L
Dog Lupus familis XP_543550 1017 111618 S494 S L A G T M L S S H S N P Q L
Cat Felis silvestris
Mouse Mus musculus Q61666 1015 111748 S494 S L A G T M L S S P S G Q Q L
Rat Rattus norvegicus NP_001129232 1015 111665 S494 S L A G T M L S S P S G Q Q L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P79987 1019 112055 G494 P I S G T L A G S I M S S Q N
Frog Xenopus laevis Q8QFR2 1013 112021 S494 S L P G S M M S S Q S N Q Q L
Zebra Danio Brachydanio rerio XP_696478 1010 111223 L494 G S S A S T Q L T P Q I S S D
Tiger Blowfish Takifugu rubipres O42611 1025 111838 S494 L P S G S S M S N Q L T S Q L
Fruit Fly Dros. melanogaster O17468 1047 113397 P491 S A A T P L M P L E P L V S K
Honey Bee Apis mellifera XP_001122939 838 91355 S340 G L R L A A C S W D G S V V L
Nematode Worm Caenorhab. elegans Q09589 935 103412 T437 Q S S D I Q L T K S M E D N S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q32SG6 964 105548 D466 K T A G P T A D D V K K G N Q
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LXN4 1051 115544 I494 V P Q Q E N N I M I N G E S H
Baker's Yeast Sacchar. cerevisiae P32479 840 93871 T342 K S L A V W S T S R P R P I L
Red Bread Mold Neurospora crassa Q7RZI0 1035 112420 T492 L K S R V T I T K D G K K R V
Conservation
Percent
Protein Identity: 100 99.9 88.4 96.5 N.A. 95.7 95.5 N.A. N.A. 86 78 69.8 67.7 31.1 40 26.5 N.A.
Protein Similarity: 100 99.9 88.9 98 N.A. 97.5 97.7 N.A. N.A. 93.1 88.5 83.2 81.3 48 55.1 46.1 N.A.
P-Site Identity: 100 100 100 93.3 N.A. 80 80 N.A. N.A. 33.3 60 0 26.6 13.3 26.6 6.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 80 80 N.A. N.A. 53.3 80 20 60 26.6 26.6 20 N.A.
Percent
Protein Identity: N.A. 25.6 N.A. 25 22.4 25.9
Protein Similarity: N.A. 43.7 N.A. 43.3 41.2 45.8
P-Site Identity: N.A. 13.3 N.A. 0 20 0
P-Site Similarity: N.A. 13.3 N.A. 6.6 26.6 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 6 48 12 6 6 12 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 6 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 6 0 0 0 6 6 12 0 0 6 0 6 % D
% Glu: 0 0 0 0 6 0 0 0 0 6 0 6 6 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 12 0 0 59 0 0 0 6 0 0 12 18 6 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 24 0 0 0 0 6 % H
% Ile: 0 6 0 0 6 0 6 6 0 12 0 6 0 6 0 % I
% Lys: 12 6 0 0 0 0 0 0 12 0 6 12 6 0 6 % K
% Leu: 12 48 6 6 0 12 42 6 6 0 6 6 0 0 59 % L
% Met: 0 0 0 0 0 42 18 0 6 0 12 0 0 0 0 % M
% Asn: 0 0 0 0 0 6 6 0 6 0 6 12 0 12 6 % N
% Pro: 6 12 6 0 12 0 0 6 0 18 12 0 30 0 0 % P
% Gln: 6 0 6 6 0 6 6 0 0 12 6 0 18 53 6 % Q
% Arg: 0 0 6 6 0 0 0 0 0 6 0 6 0 6 0 % R
% Ser: 48 18 30 0 18 6 6 53 53 6 42 30 18 18 6 % S
% Thr: 0 6 0 6 42 18 0 18 6 0 0 6 0 0 0 % T
% Val: 6 0 0 0 12 0 0 0 0 6 0 0 12 6 6 % V
% Trp: 0 0 0 0 0 6 0 0 6 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _