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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HIRA All Species: 36.97
Human Site: S969 Identified Species: 50.83
UniProt: P54198 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.31
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54198 NP_003316.3 1017 111835 S969 L L G P V H Y S T G S Q W E S
Chimpanzee Pan troglodytes XP_001165585 1017 111787 S969 L L G P V H Y S T G S Q W E S
Rhesus Macaque Macaca mulatta XP_001112873 1138 124408 S1090 L L G P V H Y S T G S Q W E S
Dog Lupus familis XP_543550 1017 111618 S969 L L G P V H Y S T G S Q W E S
Cat Felis silvestris
Mouse Mus musculus Q61666 1015 111748 S967 L L G P V H C S T G S Q W E S
Rat Rattus norvegicus NP_001129232 1015 111665 S967 L L G P V H C S T G S Q W E S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P79987 1019 112055 S975 L L G P V H Y S R G S Q W E S
Frog Xenopus laevis Q8QFR2 1013 112021 S965 L L G P V H R S S D S Q W E S
Zebra Danio Brachydanio rerio XP_696478 1010 111223 S962 L L G P V H K S S S S S W E S
Tiger Blowfish Takifugu rubipres O42611 1025 111838 S977 L L G P V H K S A T T S W E P
Fruit Fly Dros. melanogaster O17468 1047 113397 L987 L S P E I Q T L D S P T V C I
Honey Bee Apis mellifera XP_001122939 838 91355 D808 K K H K L L E D V L S I I G G
Nematode Worm Caenorhab. elegans Q09589 935 103412 D905 R R S A L Y D D V T R M I K L
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q32SG6 964 105548 D934 R L L N E F M D L L L E Y E T
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LXN4 1051 115544 V990 P T M N C G G V P S S L D Q I
Baker's Yeast Sacchar. cerevisiae P32479 840 93871 D810 V I K C F R L D G S S C D L L
Red Bread Mold Neurospora crassa Q7RZI0 1035 112420 D968 L I G G V L R D A D D G E G W
Conservation
Percent
Protein Identity: 100 99.9 88.4 96.5 N.A. 95.7 95.5 N.A. N.A. 86 78 69.8 67.7 31.1 40 26.5 N.A.
Protein Similarity: 100 99.9 88.9 98 N.A. 97.5 97.7 N.A. N.A. 93.1 88.5 83.2 81.3 48 55.1 46.1 N.A.
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. N.A. 93.3 80 73.3 60 6.6 6.6 0 N.A.
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. N.A. 93.3 86.6 80 66.6 13.3 13.3 20 N.A.
Percent
Protein Identity: N.A. 25.6 N.A. 25 22.4 25.9
Protein Similarity: N.A. 43.7 N.A. 43.3 41.2 45.8
P-Site Identity: N.A. 13.3 N.A. 6.6 6.6 20
P-Site Similarity: N.A. 33.3 N.A. 13.3 20 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 6 0 0 0 0 12 0 0 0 0 0 0 % A
% Cys: 0 0 0 6 6 0 12 0 0 0 0 6 0 6 0 % C
% Asp: 0 0 0 0 0 0 6 30 6 12 6 0 12 0 0 % D
% Glu: 0 0 0 6 6 0 6 0 0 0 0 6 6 65 0 % E
% Phe: 0 0 0 0 6 6 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 65 6 0 6 6 0 6 42 0 6 0 12 6 % G
% His: 0 0 6 0 0 59 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 12 0 0 6 0 0 0 0 0 0 6 12 0 12 % I
% Lys: 6 6 6 6 0 0 12 0 0 0 0 0 0 6 0 % K
% Leu: 71 65 6 0 12 12 6 6 6 12 6 6 0 6 12 % L
% Met: 0 0 6 0 0 0 6 0 0 0 0 6 0 0 0 % M
% Asn: 0 0 0 12 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 6 0 6 59 0 0 0 0 6 0 6 0 0 0 6 % P
% Gln: 0 0 0 0 0 6 0 0 0 0 0 48 0 6 0 % Q
% Arg: 12 6 0 0 0 6 12 0 6 0 6 0 0 0 0 % R
% Ser: 0 6 6 0 0 0 0 59 12 24 71 12 0 0 53 % S
% Thr: 0 6 0 0 0 0 6 0 36 12 6 6 0 0 6 % T
% Val: 6 0 0 0 65 0 0 6 12 0 0 0 6 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 59 0 6 % W
% Tyr: 0 0 0 0 0 6 30 0 0 0 0 0 6 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _