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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HIRA All Species: 36.67
Human Site: S976 Identified Species: 50.42
UniProt: P54198 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54198 NP_003316.3 1017 111835 S976 S T G S Q W E S T V V G L R K
Chimpanzee Pan troglodytes XP_001165585 1017 111787 S976 S T G S Q W E S T V V G L R K
Rhesus Macaque Macaca mulatta XP_001112873 1138 124408 S1097 S T G S Q W E S T V V G L R K
Dog Lupus familis XP_543550 1017 111618 S976 S T G S Q W E S T V V G L R K
Cat Felis silvestris
Mouse Mus musculus Q61666 1015 111748 S974 S T G S Q W E S T V V G L R K
Rat Rattus norvegicus NP_001129232 1015 111665 S974 S T G S Q W E S T V V G L R K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P79987 1019 112055 S982 S R G S Q W E S T V M G L R K
Frog Xenopus laevis Q8QFR2 1013 112021 S972 S S D S Q W E S R I L G L W K
Zebra Danio Brachydanio rerio XP_696478 1010 111223 S969 S S S S S W E S T V L G L R K
Tiger Blowfish Takifugu rubipres O42611 1025 111838 P984 S A T T S W E P T T L G L R K
Fruit Fly Dros. melanogaster O17468 1047 113397 I994 L D S P T V C I D D E I L S A
Honey Bee Apis mellifera XP_001122939 838 91355 G815 D V L S I I G G H L R W Q R L
Nematode Worm Caenorhab. elegans Q09589 935 103412 L912 D V T R M I K L K Q P A I A A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q32SG6 964 105548 T941 D L L L E Y E T D V T L I P Q
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LXN4 1051 115544 I997 V P S S L D Q I G S D P P A M
Baker's Yeast Sacchar. cerevisiae P32479 840 93871 L817 D G S S C D L L L E V G D P K
Red Bread Mold Neurospora crassa Q7RZI0 1035 112420 W975 D A D D G E G W F S K Q D K L
Conservation
Percent
Protein Identity: 100 99.9 88.4 96.5 N.A. 95.7 95.5 N.A. N.A. 86 78 69.8 67.7 31.1 40 26.5 N.A.
Protein Similarity: 100 99.9 88.9 98 N.A. 97.5 97.7 N.A. N.A. 93.1 88.5 83.2 81.3 48 55.1 46.1 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. N.A. 86.6 60 73.3 53.3 6.6 13.3 0 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 93.3 80 86.6 66.6 6.6 20 13.3 N.A.
Percent
Protein Identity: N.A. 25.6 N.A. 25 22.4 25.9
Protein Similarity: N.A. 43.7 N.A. 43.3 41.2 45.8
P-Site Identity: N.A. 13.3 N.A. 6.6 26.6 0
P-Site Similarity: N.A. 46.6 N.A. 13.3 26.6 6.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 12 0 0 0 0 0 0 0 0 0 6 0 12 12 % A
% Cys: 0 0 0 0 6 0 6 0 0 0 0 0 0 0 0 % C
% Asp: 30 6 12 6 0 12 0 0 12 6 6 0 12 0 0 % D
% Glu: 0 0 0 0 6 6 65 0 0 6 6 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 6 0 0 0 0 0 0 % F
% Gly: 0 6 42 0 6 0 12 6 6 0 0 65 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 6 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 6 12 0 12 0 6 0 6 12 0 0 % I
% Lys: 0 0 0 0 0 0 6 0 6 0 6 0 0 6 65 % K
% Leu: 6 6 12 6 6 0 6 12 6 6 18 6 65 0 12 % L
% Met: 0 0 0 0 6 0 0 0 0 0 6 0 0 0 6 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 6 0 6 0 0 0 6 0 0 6 6 6 12 0 % P
% Gln: 0 0 0 0 48 0 6 0 0 6 0 6 6 0 6 % Q
% Arg: 0 6 0 6 0 0 0 0 6 0 6 0 0 59 0 % R
% Ser: 59 12 24 71 12 0 0 53 0 12 0 0 0 6 0 % S
% Thr: 0 36 12 6 6 0 0 6 53 6 6 0 0 0 0 % T
% Val: 6 12 0 0 0 6 0 0 0 53 42 0 0 0 0 % V
% Trp: 0 0 0 0 0 59 0 6 0 0 0 6 0 6 0 % W
% Tyr: 0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _