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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HIRA All Species: 47.88
Human Site: T1005 Identified Species: 65.83
UniProt: P54198 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54198 NP_003316.3 1017 111835 T1005 L R F Q R L F T E C Q E Q L D
Chimpanzee Pan troglodytes XP_001165585 1017 111787 T1005 L R F Q R L F T E C Q E Q L D
Rhesus Macaque Macaca mulatta XP_001112873 1138 124408 T1126 L R F Q R L F T E C Q E Q L D
Dog Lupus familis XP_543550 1017 111618 T1005 L R F Q R L F T E C Q E Q L D
Cat Felis silvestris
Mouse Mus musculus Q61666 1015 111748 T1003 L R F Q R L F T E C Q E Q L D
Rat Rattus norvegicus NP_001129232 1015 111665 T1003 L R F Q R L F T E C Q E Q L D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P79987 1019 112055 T1010 N L F Q R L F T E Y Q E Q L D
Frog Xenopus laevis Q8QFR2 1013 112021 T1001 L R F Q R L F T E Y Q E Q L D
Zebra Danio Brachydanio rerio XP_696478 1010 111223 T998 L R F Q R L F T E Y Q D Q L E
Tiger Blowfish Takifugu rubipres O42611 1025 111838 T1013 L R F Q R L F T E Y Q D Q L E
Fruit Fly Dros. melanogaster O17468 1047 113397 S1040 V A G S A P V S S S K T D Q T
Honey Bee Apis mellifera XP_001122939 838 91355 T831 L E Y M E Q L T A L K N Q I N
Nematode Worm Caenorhab. elegans Q09589 935 103412 S928 I V A G V A A S T T T K S L F
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q32SG6 964 105548 G957 G T E G N G N G N D K V M T S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LXN4 1051 115544 S1036 G V C E K T G S E D R D K Q D
Baker's Yeast Sacchar. cerevisiae P32479 840 93871 L833 V Y K W T K D L G C W S L Y K
Red Bread Mold Neurospora crassa Q7RZI0 1035 112420 T1027 G D E E K E T T D E G M E V E
Conservation
Percent
Protein Identity: 100 99.9 88.4 96.5 N.A. 95.7 95.5 N.A. N.A. 86 78 69.8 67.7 31.1 40 26.5 N.A.
Protein Similarity: 100 99.9 88.9 98 N.A. 97.5 97.7 N.A. N.A. 93.1 88.5 83.2 81.3 48 55.1 46.1 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. N.A. 80 93.3 80 80 0 20 6.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 80 93.3 93.3 93.3 20 46.6 26.6 N.A.
Percent
Protein Identity: N.A. 25.6 N.A. 25 22.4 25.9
Protein Similarity: N.A. 43.7 N.A. 43.3 41.2 45.8
P-Site Identity: N.A. 0 N.A. 13.3 6.6 6.6
P-Site Similarity: N.A. 6.6 N.A. 53.3 13.3 46.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 6 6 0 6 6 6 0 6 0 0 0 0 0 0 % A
% Cys: 0 0 6 0 0 0 0 0 0 42 0 0 0 0 0 % C
% Asp: 0 6 0 0 0 0 6 0 6 12 0 18 6 0 53 % D
% Glu: 0 6 12 12 6 6 0 0 65 6 0 48 6 0 18 % E
% Phe: 0 0 59 0 0 0 59 0 0 0 0 0 0 0 6 % F
% Gly: 18 0 6 12 0 6 6 6 6 0 6 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 6 0 0 0 0 0 0 0 0 0 0 0 0 6 0 % I
% Lys: 0 0 6 0 12 6 0 0 0 0 18 6 6 0 6 % K
% Leu: 59 6 0 0 0 59 6 6 0 6 0 0 6 65 0 % L
% Met: 0 0 0 6 0 0 0 0 0 0 0 6 6 0 0 % M
% Asn: 6 0 0 0 6 0 6 0 6 0 0 6 0 0 6 % N
% Pro: 0 0 0 0 0 6 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 59 0 6 0 0 0 0 59 0 65 12 0 % Q
% Arg: 0 53 0 0 59 0 0 0 0 0 6 0 0 0 0 % R
% Ser: 0 0 0 6 0 0 0 18 6 6 0 6 6 0 6 % S
% Thr: 0 6 0 0 6 6 6 71 6 6 6 6 0 6 6 % T
% Val: 12 12 0 0 6 0 6 0 0 0 0 6 0 6 0 % V
% Trp: 0 0 0 6 0 0 0 0 0 0 6 0 0 0 0 % W
% Tyr: 0 6 6 0 0 0 0 0 0 24 0 0 0 6 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _