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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PMS1
All Species:
8.79
Human Site:
S445
Identified Species:
17.58
UniProt:
P54277
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54277
NP_000525.1
932
105830
S445
D
I
S
M
S
N
V
S
W
E
N
S
Q
T
E
Chimpanzee
Pan troglodytes
XP_515987
1061
120272
S574
D
I
S
M
S
N
V
S
W
E
N
S
Q
T
E
Rhesus Macaque
Macaca mulatta
XP_001103074
831
93641
G400
D
M
H
N
D
E
S
G
K
N
T
D
D
C
L
Dog
Lupus familis
XP_536002
930
105612
S445
E
I
P
M
N
N
L
S
C
E
D
A
Q
K
E
Cat
Felis silvestris
Mouse
Mus musculus
P54279
859
95207
A424
S
I
S
R
L
R
E
A
F
S
L
H
P
T
K
Rat
Rattus norvegicus
NP_001009535
919
103710
H445
S
E
A
N
Q
S
K
H
S
E
T
H
S
A
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507554
871
92244
A436
D
G
H
P
P
D
G
A
S
P
D
I
I
P
P
Chicken
Gallus gallus
NP_001006508
916
103017
Q441
R
L
L
C
E
E
E
Q
K
G
Q
N
T
T
G
Frog
Xenopus laevis
NP_001079545
925
103654
T445
Q
D
E
A
I
A
D
T
G
L
H
F
A
V
S
Zebra Danio
Brachydanio rerio
NP_958476
896
98728
L436
V
M
N
S
T
A
D
L
N
S
N
S
P
K
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001188203
734
80915
E303
Y
K
A
T
P
P
V
E
P
T
L
P
G
Q
S
Poplar Tree
Populus trichocarpa
XP_002321013
915
101109
A447
T
N
S
N
S
C
K
A
T
T
H
L
N
I
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.4
86.2
83.6
N.A.
22.3
73.7
N.A.
35.9
58.3
50.7
46.1
N.A.
N.A.
N.A.
N.A.
28.3
Protein Similarity:
100
87.7
87.7
92.6
N.A.
41.6
86
N.A.
50.7
74.6
69
64.6
N.A.
N.A.
N.A.
N.A.
45.8
P-Site Identity:
100
100
6.6
46.6
N.A.
20
6.6
N.A.
6.6
6.6
0
13.3
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
13.3
80
N.A.
40
26.6
N.A.
26.6
20
13.3
33.3
N.A.
N.A.
N.A.
N.A.
13.3
Percent
Protein Identity:
23.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
45.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
17
9
0
17
0
25
0
0
0
9
9
9
9
% A
% Cys:
0
0
0
9
0
9
0
0
9
0
0
0
0
9
0
% C
% Asp:
34
9
0
0
9
9
17
0
0
0
17
9
9
0
9
% D
% Glu:
9
9
9
0
9
17
17
9
0
34
0
0
0
0
25
% E
% Phe:
0
0
0
0
0
0
0
0
9
0
0
9
0
0
0
% F
% Gly:
0
9
0
0
0
0
9
9
9
9
0
0
9
0
9
% G
% His:
0
0
17
0
0
0
0
9
0
0
17
17
0
0
0
% H
% Ile:
0
34
0
0
9
0
0
0
0
0
0
9
9
9
0
% I
% Lys:
0
9
0
0
0
0
17
0
17
0
0
0
0
17
9
% K
% Leu:
0
9
9
0
9
0
9
9
0
9
17
9
0
0
9
% L
% Met:
0
17
0
25
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
9
9
25
9
25
0
0
9
9
25
9
9
0
0
% N
% Pro:
0
0
9
9
17
9
0
0
9
9
0
9
17
9
9
% P
% Gln:
9
0
0
0
9
0
0
9
0
0
9
0
25
9
0
% Q
% Arg:
9
0
0
9
0
9
0
0
0
0
0
0
0
0
0
% R
% Ser:
17
0
34
9
25
9
9
25
17
17
0
25
9
0
17
% S
% Thr:
9
0
0
9
9
0
0
9
9
17
17
0
9
34
0
% T
% Val:
9
0
0
0
0
0
25
0
0
0
0
0
0
9
9
% V
% Trp:
0
0
0
0
0
0
0
0
17
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _