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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PMS1 All Species: 14.55
Human Site: S643 Identified Species: 29.09
UniProt: P54277 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54277 NP_000525.1 932 105830 S643 K R A I E Q E S Q M S L K D G
Chimpanzee Pan troglodytes XP_515987 1061 120272 S772 K R A I E Q E S Q M S L K D G
Rhesus Macaque Macaca mulatta XP_001103074 831 93641 P594 A Q F L I E N P K T S L E D A
Dog Lupus familis XP_536002 930 105612 S643 K R A I E Q E S Q I S L K D G
Cat Felis silvestris
Mouse Mus musculus P54279 859 95207 S618 R I V L L E F S L S S L A K R
Rat Rattus norvegicus NP_001009535 919 103710 G639 A Q V S L K D G R K K L R A T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507554 871 92244 D630 P T G G R R V D G S T S L T D
Chicken Gallus gallus NP_001006508 916 103017 A635 N K A M Q Q A A R R P V K E N
Frog Xenopus laevis NP_001079545 925 103654 D639 E H V E K Q K D S E K R Q K M
Zebra Danio Brachydanio rerio NP_958476 896 98728 L631 P L A N Q Q A L D K L F S S Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001188203 734 80915 S497 G Q S L T E P S G K I V Q P S
Poplar Tree Populus trichocarpa XP_002321013 915 101109 S654 Q R L S R L Q S G K F T F G G
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 87.4 86.2 83.6 N.A. 22.3 73.7 N.A. 35.9 58.3 50.7 46.1 N.A. N.A. N.A. N.A. 28.3
Protein Similarity: 100 87.7 87.7 92.6 N.A. 41.6 86 N.A. 50.7 74.6 69 64.6 N.A. N.A. N.A. N.A. 45.8
P-Site Identity: 100 100 20 93.3 N.A. 20 6.6 N.A. 0 20 6.6 13.3 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 53.3 100 N.A. 40 40 N.A. 13.3 66.6 33.3 20 N.A. N.A. N.A. N.A. 46.6
Percent
Protein Identity: 23.7 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 45.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 20 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 33.3 N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 17 0 42 0 0 0 17 9 0 0 0 0 9 9 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 9 17 9 0 0 0 0 34 9 % D
% Glu: 9 0 0 9 25 25 25 0 0 9 0 0 9 9 0 % E
% Phe: 0 0 9 0 0 0 9 0 0 0 9 9 9 0 0 % F
% Gly: 9 0 9 9 0 0 0 9 25 0 0 0 0 9 34 % G
% His: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 9 0 25 9 0 0 0 0 9 9 0 0 0 0 % I
% Lys: 25 9 0 0 9 9 9 0 9 34 17 0 34 17 0 % K
% Leu: 0 9 9 25 17 9 0 9 9 0 9 50 9 0 0 % L
% Met: 0 0 0 9 0 0 0 0 0 17 0 0 0 0 9 % M
% Asn: 9 0 0 9 0 0 9 0 0 0 0 0 0 0 9 % N
% Pro: 17 0 0 0 0 0 9 9 0 0 9 0 0 9 0 % P
% Gln: 9 25 0 0 17 50 9 0 25 0 0 0 17 0 9 % Q
% Arg: 9 34 0 0 17 9 0 0 17 9 0 9 9 0 9 % R
% Ser: 0 0 9 17 0 0 0 50 9 17 42 9 9 9 9 % S
% Thr: 0 9 0 0 9 0 0 0 0 9 9 9 0 9 9 % T
% Val: 0 0 25 0 0 0 9 0 0 0 0 17 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _