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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PMS1 All Species: 17.27
Human Site: T814 Identified Species: 34.55
UniProt: P54277 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54277 NP_000525.1 932 105830 T814 Y L S D P R L T A N G F K I K
Chimpanzee Pan troglodytes XP_515987 1061 120272 T943 Y L S D P R L T A N G F K I K
Rhesus Macaque Macaca mulatta XP_001103074 831 93641 E729 I P G V S I T E N Y L E I E G
Dog Lupus familis XP_536002 930 105612 T812 Y L S D P R L T A N G F K I K
Cat Felis silvestris
Mouse Mus musculus P54279 859 95207 P757 F V I D E D A P V T E R A K L
Rat Rattus norvegicus NP_001009535 919 103710 T801 Y L C D P R L T A N G F K I R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507554 871 92244 E765 A A E P D L P E A D V P V V Q
Chicken Gallus gallus NP_001006508 916 103017 V796 Y L S D P R L V A N G F Q I K
Frog Xenopus laevis NP_001079545 925 103654 T804 Y F S D P R L T A N G F L I K
Zebra Danio Brachydanio rerio NP_958476 896 98728 V767 S L T D P R L V A N G F E I R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001188203 734 80915 V632 P G T Q Y D L V G K A P V M R
Poplar Tree Populus trichocarpa XP_002321013 915 101109 P793 E E D P H A L P G H H F K L K
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 87.4 86.2 83.6 N.A. 22.3 73.7 N.A. 35.9 58.3 50.7 46.1 N.A. N.A. N.A. N.A. 28.3
Protein Similarity: 100 87.7 87.7 92.6 N.A. 41.6 86 N.A. 50.7 74.6 69 64.6 N.A. N.A. N.A. N.A. 45.8
P-Site Identity: 100 100 0 100 N.A. 6.6 86.6 N.A. 6.6 86.6 86.6 66.6 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 0 100 N.A. 20 93.3 N.A. 26.6 93.3 86.6 86.6 N.A. N.A. N.A. N.A. 26.6
Percent
Protein Identity: 23.7 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 45.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 26.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 40 N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 9 0 0 0 9 9 0 67 0 9 0 9 0 0 % A
% Cys: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 9 67 9 17 0 0 0 9 0 0 0 0 0 % D
% Glu: 9 9 9 0 9 0 0 17 0 0 9 9 9 9 0 % E
% Phe: 9 9 0 0 0 0 0 0 0 0 0 67 0 0 0 % F
% Gly: 0 9 9 0 0 0 0 0 17 0 59 0 0 0 9 % G
% His: 0 0 0 0 9 0 0 0 0 9 9 0 0 0 0 % H
% Ile: 9 0 9 0 0 9 0 0 0 0 0 0 9 59 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 9 0 0 42 9 50 % K
% Leu: 0 50 0 0 0 9 75 0 0 0 9 0 9 9 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % M
% Asn: 0 0 0 0 0 0 0 0 9 59 0 0 0 0 0 % N
% Pro: 9 9 0 17 59 0 9 17 0 0 0 17 0 0 0 % P
% Gln: 0 0 0 9 0 0 0 0 0 0 0 0 9 0 9 % Q
% Arg: 0 0 0 0 0 59 0 0 0 0 0 9 0 0 25 % R
% Ser: 9 0 42 0 9 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 17 0 0 0 9 42 0 9 0 0 0 0 0 % T
% Val: 0 9 0 9 0 0 0 25 9 0 9 0 17 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 50 0 0 0 9 0 0 0 0 9 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _