Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PMS1 All Species: 7.58
Human Site: Y533 Identified Species: 15.15
UniProt: P54277 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54277 NP_000525.1 932 105830 Y533 C K V S N N N Y P I P E Q M N
Chimpanzee Pan troglodytes XP_515987 1061 120272 Y662 C K V S N N N Y P I P E Q M N
Rhesus Macaque Macaca mulatta XP_001103074 831 93641 L487 E N E E E A G L E N S L E I S
Dog Lupus familis XP_536002 930 105612 Y533 C K Q N N N A Y P S P E L K N
Cat Felis silvestris
Mouse Mus musculus P54279 859 95207 P511 S E E E F S T P E V A S S F S
Rat Rattus norvegicus NP_001009535 919 103710 V532 P E P E N L S V G P G S R T S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507554 871 92244 E523 P Q G G T Q G E P G R G A G S
Chicken Gallus gallus NP_001006508 916 103017 Q528 Q S E R S D E Q S H D P Q I P
Frog Xenopus laevis NP_001079545 925 103654 Q532 T G E A S N V Q N S K D T N N
Zebra Danio Brachydanio rerio NP_958476 896 98728 N523 T A Y E L I S N R S V R Q P S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001188203 734 80915 K390 S Q N L M H S K G I D D S H M
Poplar Tree Populus trichocarpa XP_002321013 915 101109 I538 L L F N H H H I D D S T E F T
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 87.4 86.2 83.6 N.A. 22.3 73.7 N.A. 35.9 58.3 50.7 46.1 N.A. N.A. N.A. N.A. 28.3
Protein Similarity: 100 87.7 87.7 92.6 N.A. 41.6 86 N.A. 50.7 74.6 69 64.6 N.A. N.A. N.A. N.A. 45.8
P-Site Identity: 100 100 0 60 N.A. 0 6.6 N.A. 6.6 6.6 13.3 6.6 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 20 66.6 N.A. 26.6 33.3 N.A. 20 26.6 33.3 20 N.A. N.A. N.A. N.A. 33.3
Percent
Protein Identity: 23.7 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 45.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 0 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 33.3 N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 0 9 0 9 9 0 0 0 9 0 9 0 0 % A
% Cys: 25 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 9 0 0 9 9 17 17 0 0 0 % D
% Glu: 9 17 34 34 9 0 9 9 17 0 0 25 17 0 0 % E
% Phe: 0 0 9 0 9 0 0 0 0 0 0 0 0 17 0 % F
% Gly: 0 9 9 9 0 0 17 0 17 9 9 9 0 9 0 % G
% His: 0 0 0 0 9 17 9 0 0 9 0 0 0 9 0 % H
% Ile: 0 0 0 0 0 9 0 9 0 25 0 0 0 17 0 % I
% Lys: 0 25 0 0 0 0 0 9 0 0 9 0 0 9 0 % K
% Leu: 9 9 0 9 9 9 0 9 0 0 0 9 9 0 0 % L
% Met: 0 0 0 0 9 0 0 0 0 0 0 0 0 17 9 % M
% Asn: 0 9 9 17 34 34 17 9 9 9 0 0 0 9 34 % N
% Pro: 17 0 9 0 0 0 0 9 34 9 25 9 0 9 9 % P
% Gln: 9 17 9 0 0 9 0 17 0 0 0 0 34 0 0 % Q
% Arg: 0 0 0 9 0 0 0 0 9 0 9 9 9 0 0 % R
% Ser: 17 9 0 17 17 9 25 0 9 25 17 17 17 0 42 % S
% Thr: 17 0 0 0 9 0 9 0 0 0 0 9 9 9 9 % T
% Val: 0 0 17 0 0 0 9 9 0 9 9 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 9 0 0 0 0 25 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _