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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP14
All Species:
25.45
Human Site:
S143
Identified Species:
37.33
UniProt:
P54578
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54578
NP_001032411.1
494
56069
S143
Y
A
G
A
L
R
A
S
G
E
M
A
S
A
Q
Chimpanzee
Pan troglodytes
P60051
493
55922
S143
Y
A
G
A
L
R
A
S
G
E
M
A
S
A
Q
Rhesus Macaque
Macaca mulatta
XP_001090667
458
52239
I138
T
S
S
S
I
P
P
I
I
L
L
Q
F
L
H
Dog
Lupus familis
XP_537306
545
61461
S194
Y
A
G
A
L
R
A
S
G
E
M
A
S
A
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q9JMA1
493
55983
S143
Y
A
G
A
L
R
A
S
G
E
M
A
S
A
Q
Rat
Rattus norvegicus
NP_001008302
493
55958
S143
Y
A
G
A
L
R
A
S
G
E
M
A
S
A
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519267
431
48760
I111
S
S
S
S
I
P
P
I
I
L
L
Q
F
L
H
Chicken
Gallus gallus
XP_419150
492
55612
S143
Y
G
G
A
L
R
A
S
G
E
M
A
S
A
Q
Frog
Xenopus laevis
Q6GNI6
523
60030
L156
T
K
R
E
L
E
L
L
Q
H
N
P
K
R
R
Zebra Danio
Brachydanio rerio
A6H8I0
506
58102
L161
C
T
I
G
L
R
G
L
I
N
L
G
N
T
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609377
475
53689
T142
F
S
N
D
G
T
D
T
M
S
T
A
F
S
I
Honey Bee
Apis mellifera
XP_395043
497
56311
A144
F
P
G
G
L
A
A
A
G
S
S
S
L
V
P
Nematode Worm
Caenorhab. elegans
Q17361
489
55859
R142
R
I
R
E
H
N
D
R
L
C
H
N
L
A
T
Sea Urchin
Strong. purpuratus
XP_786966
516
58357
A143
Y
Q
G
N
M
N
M
A
I
A
A
S
A
P
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q949Y0
482
53677
N142
Y
S
L
A
A
R
S
N
D
V
D
Q
T
S
H
Baker's Yeast
Sacchar. cerevisiae
P43593
499
57092
S147
Y
N
P
S
Q
G
V
S
N
S
G
A
Q
D
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
92.5
89.9
N.A.
96.7
96.5
N.A.
80.3
90.4
21.4
20.1
N.A.
54.6
61.7
41.9
61
Protein Similarity:
100
99.8
92.7
90.2
N.A.
98.5
98.7
N.A.
83.8
94.9
39
38.7
N.A.
71.2
80.2
61.1
76.5
P-Site Identity:
100
100
0
100
N.A.
100
100
N.A.
0
93.3
6.6
13.3
N.A.
6.6
26.6
6.6
13.3
P-Site Similarity:
100
100
26.6
100
N.A.
100
100
N.A.
26.6
93.3
13.3
26.6
N.A.
33.3
46.6
6.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.5
26
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.9
46.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
32
0
44
7
7
44
13
0
7
7
50
7
44
7
% A
% Cys:
7
0
0
0
0
0
0
0
0
7
0
0
0
0
7
% C
% Asp:
0
0
0
7
0
0
13
0
7
0
7
0
0
7
0
% D
% Glu:
0
0
0
13
0
7
0
0
0
38
0
0
0
0
7
% E
% Phe:
13
0
0
0
0
0
0
0
0
0
0
0
19
0
0
% F
% Gly:
0
7
50
13
7
7
7
0
44
0
7
7
0
0
0
% G
% His:
0
0
0
0
7
0
0
0
0
7
7
0
0
0
19
% H
% Ile:
0
7
7
0
13
0
0
13
25
0
0
0
0
0
7
% I
% Lys:
0
7
0
0
0
0
0
0
0
0
0
0
7
0
0
% K
% Leu:
0
0
7
0
57
0
7
13
7
13
19
0
13
13
0
% L
% Met:
0
0
0
0
7
0
7
0
7
0
38
0
0
0
0
% M
% Asn:
0
7
7
7
0
13
0
7
7
7
7
7
7
0
0
% N
% Pro:
0
7
7
0
0
13
13
0
0
0
0
7
0
7
7
% P
% Gln:
0
7
0
0
7
0
0
0
7
0
0
19
7
0
38
% Q
% Arg:
7
0
13
0
0
50
0
7
0
0
0
0
0
7
7
% R
% Ser:
7
25
13
19
0
0
7
44
0
19
7
13
38
13
0
% S
% Thr:
13
7
0
0
0
7
0
7
0
0
7
0
7
7
7
% T
% Val:
0
0
0
0
0
0
7
0
0
7
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
57
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _