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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP14
All Species:
21.52
Human Site:
T235
Identified Species:
31.56
UniProt:
P54578
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54578
NP_001032411.1
494
56069
T235
S
S
S
A
S
A
A
T
P
S
K
K
K
S
L
Chimpanzee
Pan troglodytes
P60051
493
55922
T235
S
S
S
A
S
A
A
T
P
S
K
K
K
S
L
Rhesus Macaque
Macaca mulatta
XP_001090667
458
52239
L207
T
P
S
K
K
K
S
L
I
D
Q
F
F
G
V
Dog
Lupus familis
XP_537306
545
61461
T286
S
S
S
A
S
A
V
T
P
S
K
K
K
S
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9JMA1
493
55983
T235
S
S
S
A
P
A
V
T
P
S
K
K
K
S
L
Rat
Rattus norvegicus
NP_001008302
493
55958
T235
S
S
S
A
S
A
V
T
P
S
K
K
K
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519267
431
48760
I180
P
P
K
K
K
S
L
I
D
Q
F
F
S
V
E
Chicken
Gallus gallus
XP_419150
492
55612
T233
T
D
S
G
A
T
A
T
A
S
K
K
K
S
L
Frog
Xenopus laevis
Q6GNI6
523
60030
S231
T
L
F
Q
E
F
Y
S
G
H
R
S
P
H
I
Zebra Danio
Brachydanio rerio
A6H8I0
506
58102
G239
T
H
A
R
H
L
A
G
Y
E
Q
Q
D
A
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609377
475
53689
V222
N
Q
E
P
S
N
T
V
Q
K
R
H
S
S
F
Honey Bee
Apis mellifera
XP_395043
497
56311
Q230
L
A
S
E
N
N
G
Q
S
Y
K
P
R
S
L
Nematode Worm
Caenorhab. elegans
Q17361
489
55859
W212
R
I
Y
G
L
S
G
W
N
I
E
S
L
F
R
Sea Urchin
Strong. purpuratus
XP_786966
516
58357
G236
E
G
A
P
A
A
A
G
A
V
A
K
R
T
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q949Y0
482
53677
A215
T
L
S
Q
S
L
K
A
P
T
S
S
E
G
A
Baker's Yeast
Sacchar. cerevisiae
P43593
499
57092
M221
F
T
Q
L
F
H
S
M
S
I
V
F
G
D
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
92.5
89.9
N.A.
96.7
96.5
N.A.
80.3
90.4
21.4
20.1
N.A.
54.6
61.7
41.9
61
Protein Similarity:
100
99.8
92.7
90.2
N.A.
98.5
98.7
N.A.
83.8
94.9
39
38.7
N.A.
71.2
80.2
61.1
76.5
P-Site Identity:
100
100
6.6
93.3
N.A.
86.6
93.3
N.A.
0
60
0
6.6
N.A.
13.3
26.6
0
20
P-Site Similarity:
100
100
33.3
93.3
N.A.
86.6
93.3
N.A.
6.6
73.3
26.6
40
N.A.
26.6
46.6
13.3
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.5
26
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.9
46.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
13
32
13
38
32
7
13
0
7
0
0
7
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
0
0
0
0
0
7
7
0
0
7
7
0
% D
% Glu:
7
0
7
7
7
0
0
0
0
7
7
0
7
0
7
% E
% Phe:
7
0
7
0
7
7
0
0
0
0
7
19
7
7
13
% F
% Gly:
0
7
0
13
0
0
13
13
7
0
0
0
7
13
0
% G
% His:
0
7
0
0
7
7
0
0
0
7
0
7
0
7
7
% H
% Ile:
0
7
0
0
0
0
0
7
7
13
0
0
0
0
7
% I
% Lys:
0
0
7
13
13
7
7
0
0
7
44
44
38
0
7
% K
% Leu:
7
13
0
7
7
13
7
7
0
0
0
0
7
0
44
% L
% Met:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
0
7
13
0
0
7
0
0
0
0
0
0
% N
% Pro:
7
13
0
13
7
0
0
0
38
0
0
7
7
0
0
% P
% Gln:
0
7
7
13
0
0
0
7
7
7
13
7
0
0
0
% Q
% Arg:
7
0
0
7
0
0
0
0
0
0
13
0
13
0
7
% R
% Ser:
32
32
57
0
38
13
13
7
13
38
7
19
13
50
0
% S
% Thr:
32
7
0
0
0
7
7
38
0
7
0
0
0
7
0
% T
% Val:
0
0
0
0
0
0
19
7
0
7
7
0
0
7
7
% V
% Trp:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
7
0
7
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _