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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FXYD2
All Species:
11.82
Human Site:
Y21
Identified Species:
32.5
UniProt:
P54710
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54710
NP_001120961.1
66
7283
Y21
G
D
V
D
P
F
Y
Y
D
Y
E
T
V
R
N
Chimpanzee
Pan troglodytes
XP_001158882
61
6792
R22
Y
Y
D
Y
E
T
V
R
N
G
G
L
I
F
A
Rhesus Macaque
Macaca mulatta
XP_001092388
61
6764
V21
F
Y
Y
D
Y
E
T
V
R
N
G
G
L
I
F
Dog
Lupus familis
XP_860824
61
6825
R22
Y
Y
D
Y
E
T
V
R
N
G
G
L
I
F
A
Cat
Felis silvestris
Mouse
Mus musculus
Q04646
70
7501
Y25
G
T
E
N
P
F
E
Y
D
Y
E
T
V
R
K
Rat
Rattus norvegicus
Q04679
66
7239
Y21
G
T
E
N
P
F
E
Y
D
Y
E
T
V
R
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521655
64
7012
Y21
M
E
R
F
H
Y
D
Y
D
A
V
R
N
G
G
Chicken
Gallus gallus
NP_001074348
95
10193
Y32
K
E
E
D
P
F
N
Y
D
Y
Q
S
L
R
I
Frog
Xenopus laevis
O13001
61
6981
T21
K
F
T
Y
D
Y
E
T
I
R
K
G
G
L
I
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
89.3
86.3
72.7
N.A.
68.5
75.7
N.A.
62.1
33.6
48.4
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
89.3
87.8
81.8
N.A.
80
84.8
N.A.
77.2
46.3
62.1
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
0
6.6
0
N.A.
66.6
66.6
N.A.
13.3
46.6
0
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
13.3
13.3
13.3
N.A.
73.3
73.3
N.A.
26.6
73.3
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
23
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
12
23
34
12
0
12
0
56
0
0
0
0
0
0
% D
% Glu:
0
23
34
0
23
12
34
0
0
0
34
0
0
0
0
% E
% Phe:
12
12
0
12
0
45
0
0
0
0
0
0
0
23
12
% F
% Gly:
34
0
0
0
0
0
0
0
0
23
34
23
12
12
12
% G
% His:
0
0
0
0
12
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
12
0
0
0
23
12
23
% I
% Lys:
23
0
0
0
0
0
0
0
0
0
12
0
0
0
23
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
23
23
12
0
% L
% Met:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
23
0
0
12
0
23
12
0
0
12
0
12
% N
% Pro:
0
0
0
0
45
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% Q
% Arg:
0
0
12
0
0
0
0
23
12
12
0
12
0
45
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% S
% Thr:
0
23
12
0
0
23
12
12
0
0
0
34
0
0
0
% T
% Val:
0
0
12
0
0
0
23
12
0
0
12
0
34
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
23
34
12
34
12
23
12
56
0
45
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _