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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NAGLU
All Species:
19.09
Human Site:
Y735
Identified Species:
35
UniProt:
P54802
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.42
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54802
NP_000254.2
743
82167
Y735
K
K
I
F
L
K
Y
Y
P
G
W
V
A
G
S
Chimpanzee
Pan troglodytes
XP_523654
743
82219
Y735
K
K
I
F
L
K
Y
Y
P
R
W
V
A
G
S
Rhesus Macaque
Macaca mulatta
XP_001095618
704
77136
Y696
K
K
I
F
L
K
Y
Y
P
R
W
V
A
G
S
Dog
Lupus familis
XP_548088
747
82985
Y736
K
K
L
F
I
K
Y
Y
P
R
L
V
A
G
S
Cat
Felis silvestris
Mouse
Mus musculus
NP_038820
739
82578
K727
D
T
V
D
L
S
K
K
I
F
L
K
Y
H
P
Rat
Rattus norvegicus
XP_001081442
739
82393
K726
G
D
T
V
D
L
S
K
K
I
F
L
K
F
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001234488
602
68769
K595
R
G
F
V
Y
N
E
K
R
Y
P
A
T
P
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_688608
757
86762
Y744
R
R
I
F
L
K
Y
Y
P
Y
A
L
K
K
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_652045
778
89728
K755
Q
D
I
F
E
T
W
K
G
Y
S
K
D
T
L
Honey Bee
Apis mellifera
XP_623833
1139
132435
Y1116
E
R
I
L
S
E
W
Y
D
P
H
L
P
F
H
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785272
767
87420
H747
R
M
K
N
G
R
K
H
S
A
T
Q
E
R
L
Poplar Tree
Populus trichocarpa
XP_002314048
806
91892
K790
K
I
Y
P
V
K
A
K
G
D
A
L
A
I
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_196873
806
92671
S797
K
G
D
A
L
A
I
S
R
H
L
L
S
K
Y
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
86
85.2
N.A.
82.2
81.1
N.A.
N.A.
53.1
N.A.
56.2
N.A.
39.8
31.2
N.A.
41.3
Protein Similarity:
100
99.7
87.6
91.6
N.A.
89.5
90
N.A.
N.A.
64.8
N.A.
73.1
N.A.
55
42.8
N.A.
58.6
P-Site Identity:
100
93.3
93.3
73.3
N.A.
6.6
0
N.A.
N.A.
0
N.A.
46.6
N.A.
13.3
13.3
N.A.
0
P-Site Similarity:
100
93.3
93.3
86.6
N.A.
13.3
13.3
N.A.
N.A.
6.6
N.A.
73.3
N.A.
26.6
46.6
N.A.
20
Percent
Protein Identity:
38.8
N.A.
N.A.
37.3
N.A.
N.A.
Protein Similarity:
58.8
N.A.
N.A.
58.9
N.A.
N.A.
P-Site Identity:
20
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
40
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
8
8
0
0
8
16
8
39
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
16
8
8
8
0
0
0
8
8
0
0
8
0
0
% D
% Glu:
8
0
0
0
8
8
8
0
0
0
0
0
8
0
0
% E
% Phe:
0
0
8
47
0
0
0
0
0
8
8
0
0
16
0
% F
% Gly:
8
16
0
0
8
0
0
0
16
8
0
0
0
31
0
% G
% His:
0
0
0
0
0
0
0
8
0
8
8
0
0
8
16
% H
% Ile:
0
8
47
0
8
0
8
0
8
8
0
0
0
8
0
% I
% Lys:
47
31
8
0
0
47
16
39
8
0
0
16
16
16
0
% K
% Leu:
0
0
8
8
47
8
0
0
0
0
24
39
0
0
16
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
8
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
8
0
0
0
0
39
8
8
0
8
8
8
% P
% Gln:
8
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
24
16
0
0
0
8
0
0
16
24
0
0
0
8
0
% R
% Ser:
0
0
0
0
8
8
8
8
8
0
8
0
8
0
31
% S
% Thr:
0
8
8
0
0
8
0
0
0
0
8
0
8
8
8
% T
% Val:
0
0
8
16
8
0
0
0
0
0
0
31
0
0
8
% V
% Trp:
0
0
0
0
0
0
16
0
0
0
24
0
0
0
0
% W
% Tyr:
0
0
8
0
8
0
39
47
0
24
0
0
8
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _