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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AK2
All Species:
31.82
Human Site:
Y190
Identified Species:
58.33
UniProt:
P54819
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54819
NP_001616.1
239
26478
Y190
L
K
I
R
L
Q
A
Y
H
T
Q
T
T
P
L
Chimpanzee
Pan troglodytes
XP_001165055
197
22071
H149
K
I
R
L
Q
A
Y
H
T
Q
T
T
P
L
I
Rhesus Macaque
Macaca mulatta
XP_001105613
202
22247
E154
K
S
G
R
S
Y
H
E
E
F
N
P
P
K
E
Dog
Lupus familis
XP_535321
241
26551
Y192
L
K
I
R
L
E
A
Y
H
T
Q
T
T
P
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9WTP6
239
26450
Y190
L
K
T
R
L
E
A
Y
H
T
Q
T
T
P
L
Rat
Rattus norvegicus
P29410
239
26361
Y190
L
K
T
R
L
E
A
Y
H
T
Q
T
T
P
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508642
232
25832
Y183
L
K
T
R
L
K
A
Y
H
T
Q
T
T
P
L
Chicken
Gallus gallus
XP_425786
240
26137
T192
D
N
E
T
A
L
K
T
R
L
K
A
Y
H
T
Frog
Xenopus laevis
Q8AVD3
241
26508
Y192
L
K
S
R
L
E
A
Y
H
T
M
T
S
P
L
Zebra Danio
Brachydanio rerio
Q1L8L9
241
26598
Y192
L
R
S
R
L
E
S
Y
H
R
Q
T
S
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9U915
240
26524
A192
A
L
K
K
R
L
E
A
Y
H
K
Q
T
K
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34346
251
27907
Y201
L
R
K
R
L
V
Q
Y
H
Q
M
T
V
P
L
Sea Urchin
Strong. purpuratus
XP_001178566
243
26511
Y192
L
K
T
R
L
E
A
Y
H
K
Q
T
A
P
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82.4
79
94.6
N.A.
94.9
92.8
N.A.
80.7
80.4
79.2
78
N.A.
63.3
N.A.
60.1
68.3
Protein Similarity:
100
82.4
81.5
97.5
N.A.
97.4
96.6
N.A.
88.2
89.1
89.6
87.9
N.A.
77.9
N.A.
73.7
81.8
P-Site Identity:
100
6.6
6.6
93.3
N.A.
86.6
86.6
N.A.
86.6
0
73.3
60
N.A.
6.6
N.A.
53.3
73.3
P-Site Similarity:
100
20
6.6
100
N.A.
93.3
93.3
N.A.
93.3
6.6
86.6
86.6
N.A.
26.6
N.A.
60
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
8
54
8
0
0
0
8
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
8
0
0
47
8
8
8
0
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
8
8
70
8
0
0
0
8
0
% H
% Ile:
0
8
16
0
0
0
0
0
0
0
0
0
0
0
8
% I
% Lys:
16
54
16
8
0
8
8
0
0
8
16
0
0
16
0
% K
% Leu:
70
8
0
8
70
16
0
0
0
8
0
0
0
8
70
% L
% Met:
0
0
0
0
0
0
0
0
0
0
16
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
0
0
0
0
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
8
16
70
8
% P
% Gln:
0
0
0
0
8
8
8
0
0
16
54
8
0
0
0
% Q
% Arg:
0
16
8
77
8
0
0
0
8
8
0
0
0
0
0
% R
% Ser:
0
8
16
0
8
0
8
0
0
0
0
0
16
0
0
% S
% Thr:
0
0
31
8
0
0
0
8
8
47
8
77
47
0
8
% T
% Val:
0
0
0
0
0
8
0
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
8
70
8
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _