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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN5
All Species:
14.55
Human Site:
Y419
Identified Species:
40
UniProt:
P54829
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54829
NP_001035059.1
565
63512
Y419
W
P
E
E
Q
V
A
Y
D
G
V
E
I
T
V
Chimpanzee
Pan troglodytes
XP_509221
657
73878
Y512
W
P
E
K
R
G
I
Y
G
K
V
E
V
L
V
Rhesus Macaque
Macaca mulatta
XP_001096604
784
87594
Y638
W
P
E
E
Q
V
V
Y
D
D
V
E
I
T
V
Dog
Lupus familis
XP_542528
578
64634
Y432
W
P
E
E
Q
V
V
Y
D
G
V
E
I
I
V
Cat
Felis silvestris
Mouse
Mus musculus
P54830
541
60797
H395
W
P
E
E
Q
V
V
H
D
G
V
E
I
T
V
Rat
Rattus norvegicus
P35234
369
42348
I244
E
D
Y
R
L
R
L
I
S
L
R
R
G
T
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512315
769
86755
Y624
W
P
E
K
R
G
I
Y
G
K
V
E
V
L
V
Chicken
Gallus gallus
XP_421017
525
60118
L397
I
Q
A
D
D
Y
R
L
R
L
I
T
L
K
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_687962
521
58630
S392
V
I
Q
A
D
D
Y
S
L
R
I
F
T
V
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
38.2
70
87.1
N.A.
86
61.9
N.A.
36.6
66.5
N.A.
55.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
54.1
70.9
89.9
N.A.
89.5
63.3
N.A.
49.1
75.9
N.A.
66.9
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
46.6
86.6
86.6
N.A.
86.6
6.6
N.A.
46.6
0
N.A.
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
66.6
86.6
86.6
N.A.
93.3
6.6
N.A.
66.6
20
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
12
12
0
0
12
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
12
0
12
23
12
0
0
45
12
0
0
0
0
0
% D
% Glu:
12
0
67
45
0
0
0
0
0
0
0
67
0
0
12
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% F
% Gly:
0
0
0
0
0
23
0
0
23
34
0
0
12
0
0
% G
% His:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% H
% Ile:
12
12
0
0
0
0
23
12
0
0
23
0
45
12
0
% I
% Lys:
0
0
0
23
0
0
0
0
0
23
0
0
0
12
23
% K
% Leu:
0
0
0
0
12
0
12
12
12
23
0
0
12
23
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
67
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
12
12
0
45
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
12
23
12
12
0
12
12
12
12
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
12
12
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
12
12
45
0
% T
% Val:
12
0
0
0
0
45
34
0
0
0
67
0
23
12
67
% V
% Trp:
67
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
12
0
0
12
12
56
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _