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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GYS2
All Species:
38.18
Human Site:
S593
Identified Species:
64.62
UniProt:
P54840
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54840
NP_068776.2
703
80989
S593
R
N
R
T
E
R
L
S
D
L
L
D
W
R
Y
Chimpanzee
Pan troglodytes
XP_520790
703
80912
S593
R
N
R
T
E
R
L
S
D
L
L
D
W
R
Y
Rhesus Macaque
Macaca mulatta
Q8MJ26
737
83768
S593
R
N
R
T
E
R
L
S
D
L
L
D
W
K
Y
Dog
Lupus familis
XP_534869
703
80957
S593
R
N
R
T
E
R
L
S
D
L
L
D
W
R
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q8VCB3
704
80866
S593
R
N
R
T
E
R
L
S
D
L
L
D
W
R
Y
Rat
Rattus norvegicus
P17625
704
80715
S593
R
N
R
T
E
R
L
S
D
L
L
D
W
R
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505471
733
83148
S593
R
N
R
T
E
R
L
S
D
L
L
D
W
K
Y
Chicken
Gallus gallus
XP_416432
704
81032
S594
R
N
R
T
E
R
L
S
D
L
L
D
W
R
Y
Frog
Xenopus laevis
NP_001084863
702
80811
R592
I
Q
R
N
R
T
E
R
L
S
D
L
L
D
W
Zebra Danio
Brachydanio rerio
NP_957474
700
80455
R591
I
Q
R
N
R
T
E
R
L
S
D
L
L
D
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFC8
709
81735
S600
N
S
V
Q
Q
L
S
S
F
M
M
E
F
S
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U2D9
672
76441
F558
N
L
S
G
F
G
C
F
M
Q
E
H
V
E
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23337
708
80492
R592
N
Q
R
N
R
T
E
R
L
S
D
L
L
D
W
Red Bread Mold
Neurospora crassa
O93869
706
80888
S583
R
N
R
T
E
R
L
S
D
L
L
D
W
K
R
Conservation
Percent
Protein Identity:
100
99.7
68.1
95.7
N.A.
94
93.3
N.A.
68
84.2
80.6
71.4
N.A.
56.9
N.A.
50.9
N.A.
Protein Similarity:
100
100
81.8
98.5
N.A.
96.5
96.3
N.A.
81.5
92.1
91.4
85.9
N.A.
73.9
N.A.
67.1
N.A.
P-Site Identity:
100
100
93.3
100
N.A.
100
100
N.A.
93.3
100
6.6
6.6
N.A.
6.6
N.A.
0
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
13.3
13.3
N.A.
46.6
N.A.
0
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
49
50.5
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
66.8
67.5
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
86.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
93.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
65
0
22
65
0
22
8
% D
% Glu:
0
0
0
0
65
0
22
0
0
0
8
8
0
8
0
% E
% Phe:
0
0
0
0
8
0
0
8
8
0
0
0
8
0
0
% F
% Gly:
0
0
0
8
0
8
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
15
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
22
0
% K
% Leu:
0
8
0
0
0
8
65
0
22
65
65
22
22
0
0
% L
% Met:
0
0
0
0
0
0
0
0
8
8
8
0
0
0
0
% M
% Asn:
22
65
0
22
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
22
0
8
8
0
0
0
0
8
0
0
0
0
0
% Q
% Arg:
65
0
86
0
22
65
0
22
0
0
0
0
0
43
15
% R
% Ser:
0
8
8
0
0
0
8
72
0
22
0
0
0
8
0
% S
% Thr:
0
0
0
65
0
22
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
8
0
0
0
0
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
65
0
22
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
58
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _