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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GYS2
All Species:
31.82
Human Site:
S647
Identified Species:
53.85
UniProt:
P54840
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54840
NP_068776.2
703
80989
S647
S
S
V
P
P
S
P
S
G
S
Q
A
S
S
P
Chimpanzee
Pan troglodytes
XP_520790
703
80912
S647
S
S
V
P
P
S
P
S
G
S
Q
A
S
S
P
Rhesus Macaque
Macaca mulatta
Q8MJ26
737
83768
S647
A
S
V
P
P
S
P
S
L
S
R
H
S
S
P
Dog
Lupus familis
XP_534869
703
80957
S647
S
S
V
P
P
S
P
S
G
S
Q
V
S
S
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8VCB3
704
80866
S647
S
S
V
P
P
S
P
S
G
S
Q
A
S
S
P
Rat
Rattus norvegicus
P17625
704
80715
S647
S
S
V
P
P
S
P
S
G
S
Q
T
S
S
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505471
733
83148
S647
A
S
V
P
P
S
P
S
L
S
R
H
S
S
P
Chicken
Gallus gallus
XP_416432
704
81032
S648
S
S
V
P
P
S
P
S
V
S
Q
H
S
S
P
Frog
Xenopus laevis
NP_001084863
702
80811
S646
R
P
S
S
V
P
P
S
P
A
V
S
Q
P
S
Zebra Danio
Brachydanio rerio
NP_957474
700
80455
S645
R
P
A
S
V
P
P
S
P
A
H
S
L
H
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFC8
709
81735
E654
V
Y
P
D
Y
V
D
E
L
S
L
Y
G
S
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9U2D9
672
76441
G612
I
L
R
N
S
N
E
G
L
S
A
L
L
D
W
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23337
708
80492
I646
A
G
G
K
K
F
K
I
A
R
P
L
S
V
P
Red Bread Mold
Neurospora crassa
O93869
706
80888
P637
P
F
S
V
P
G
S
P
R
D
R
T
G
M
M
Conservation
Percent
Protein Identity:
100
99.7
68.1
95.7
N.A.
94
93.3
N.A.
68
84.2
80.6
71.4
N.A.
56.9
N.A.
50.9
N.A.
Protein Similarity:
100
100
81.8
98.5
N.A.
96.5
96.3
N.A.
81.5
92.1
91.4
85.9
N.A.
73.9
N.A.
67.1
N.A.
P-Site Identity:
100
100
73.3
93.3
N.A.
100
93.3
N.A.
73.3
86.6
13.3
13.3
N.A.
13.3
N.A.
6.6
N.A.
P-Site Similarity:
100
100
86.6
93.3
N.A.
100
93.3
N.A.
86.6
86.6
26.6
26.6
N.A.
13.3
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
49
50.5
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
66.8
67.5
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
22
0
8
0
0
0
0
0
8
15
8
22
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
8
0
0
8
0
0
0
8
0
% D
% Glu:
0
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% E
% Phe:
0
8
0
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
8
0
0
8
0
8
36
0
0
0
15
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
8
22
0
8
0
% H
% Ile:
8
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
8
8
0
8
0
0
0
0
0
0
0
8
% K
% Leu:
0
8
0
0
0
0
0
0
29
0
8
15
15
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% M
% Asn:
0
0
0
8
0
8
0
0
0
0
0
0
0
0
0
% N
% Pro:
8
15
8
58
65
15
72
8
15
0
8
0
0
8
65
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
43
0
8
0
0
% Q
% Arg:
15
0
8
0
0
0
0
0
8
8
22
0
0
0
0
% R
% Ser:
43
58
15
15
8
58
8
72
0
72
0
15
65
65
15
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
15
0
0
0
% T
% Val:
8
0
58
8
15
8
0
0
8
0
8
8
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
8
0
0
8
0
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _