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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GYS2 All Species: 27.58
Human Site: S652 Identified Species: 46.67
UniProt: P54840 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54840 NP_068776.2 703 80989 S652 S P S G S Q A S S P Q S S D V
Chimpanzee Pan troglodytes XP_520790 703 80912 S652 S P S G S Q A S S P Q S S D V
Rhesus Macaque Macaca mulatta Q8MJ26 737 83768 S652 S P S L S R H S S P H Q S E D
Dog Lupus familis XP_534869 703 80957 S652 S P S G S Q V S S P Q S S D V
Cat Felis silvestris
Mouse Mus musculus Q8VCB3 704 80866 S652 S P S G S Q A S S P Q S S D A
Rat Rattus norvegicus P17625 704 80715 S652 S P S G S Q T S S P Q S S D V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505471 733 83148 S652 S P S L S R H S S P H Q S E G
Chicken Gallus gallus XP_416432 704 81032 S653 S P S V S Q H S S P H Q S E G
Frog Xenopus laevis NP_001084863 702 80811 Q651 P P S P A V S Q P S S P H D S
Zebra Danio Brachydanio rerio NP_957474 700 80455 L650 P P S P A H S L H S S P H H S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VFC8 709 81735 G659 V D E L S L Y G S K N N L I F
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9U2D9 672 76441 L617 N E G L S A L L D W Q N L G V
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P23337 708 80492 S651 F K I A R P L S V P G S P K V
Red Bread Mold Neurospora crassa O93869 706 80888 G642 G S P R D R T G M M T P G D F
Conservation
Percent
Protein Identity: 100 99.7 68.1 95.7 N.A. 94 93.3 N.A. 68 84.2 80.6 71.4 N.A. 56.9 N.A. 50.9 N.A.
Protein Similarity: 100 100 81.8 98.5 N.A. 96.5 96.3 N.A. 81.5 92.1 91.4 85.9 N.A. 73.9 N.A. 67.1 N.A.
P-Site Identity: 100 100 53.3 93.3 N.A. 93.3 93.3 N.A. 53.3 60 20 13.3 N.A. 13.3 N.A. 20 N.A.
P-Site Similarity: 100 100 66.6 93.3 N.A. 93.3 93.3 N.A. 66.6 66.6 33.3 26.6 N.A. 20 N.A. 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 49 50.5
Protein Similarity: N.A. N.A. N.A. N.A. 66.8 67.5
P-Site Identity: N.A. N.A. N.A. N.A. 26.6 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 15 8 22 0 0 0 0 0 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 8 0 0 0 8 0 0 0 0 50 8 % D
% Glu: 0 8 8 0 0 0 0 0 0 0 0 0 0 22 0 % E
% Phe: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 15 % F
% Gly: 8 0 8 36 0 0 0 15 0 0 8 0 8 8 15 % G
% His: 0 0 0 0 0 8 22 0 8 0 22 0 15 8 0 % H
% Ile: 0 0 8 0 0 0 0 0 0 0 0 0 0 8 0 % I
% Lys: 0 8 0 0 0 0 0 0 0 8 0 0 0 8 0 % K
% Leu: 0 0 0 29 0 8 15 15 0 0 0 0 15 0 0 % L
% Met: 0 0 0 0 0 0 0 0 8 8 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 0 0 0 0 0 8 15 0 0 0 % N
% Pro: 15 72 8 15 0 8 0 0 8 65 0 22 8 0 0 % P
% Gln: 0 0 0 0 0 43 0 8 0 0 43 22 0 0 0 % Q
% Arg: 0 0 0 8 8 22 0 0 0 0 0 0 0 0 0 % R
% Ser: 58 8 72 0 72 0 15 65 65 15 15 43 58 0 15 % S
% Thr: 0 0 0 0 0 0 15 0 0 0 8 0 0 0 0 % T
% Val: 8 0 0 8 0 8 8 0 8 0 0 0 0 0 43 % V
% Trp: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _