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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GYS2 All Species: 13.94
Human Site: S686 Identified Species: 23.59
UniProt: P54840 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54840 NP_068776.2 703 80989 S686 L N I K S P F S L S H V P H G
Chimpanzee Pan troglodytes XP_520790 703 80912 S686 L N I K S P F S L S H V P H G
Rhesus Macaque Macaca mulatta Q8MJ26 737 83768 R686 E E A A K D R R N I R A P E W
Dog Lupus familis XP_534869 703 80957 S686 L N I K S P F S L G R V P R G
Cat Felis silvestris
Mouse Mus musculus Q8VCB3 704 80866 F686 R L N I K S P F S L N H F P K
Rat Rattus norvegicus P17625 704 80715 F686 R L N I K S P F S L N H I P K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505471 733 83148 L686 D R R N I R A L E W Q R R P S
Chicken Gallus gallus XP_416432 704 81032 S687 Q N I K S P F S L G V L P Q G
Frog Xenopus laevis NP_001084863 702 80811 S685 Q N I K S T F S F G P V S R G
Zebra Danio Brachydanio rerio NP_957474 700 80455 N684 V N I R Q P Y N L P N R N K N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VFC8 709 81735 D693 P S V H G S D D E D S V D E E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9U2D9 672 76441 K651 I M R D N E G K V P S A A T S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P23337 708 80492 N685 N N A D D Y F N L S T N G A I
Red Bread Mold Neurospora crassa O93869 706 80888 E676 L P E E E D P E E Y P F P L T
Conservation
Percent
Protein Identity: 100 99.7 68.1 95.7 N.A. 94 93.3 N.A. 68 84.2 80.6 71.4 N.A. 56.9 N.A. 50.9 N.A.
Protein Similarity: 100 100 81.8 98.5 N.A. 96.5 96.3 N.A. 81.5 92.1 91.4 85.9 N.A. 73.9 N.A. 67.1 N.A.
P-Site Identity: 100 100 6.6 80 N.A. 0 0 N.A. 0 66.6 53.3 26.6 N.A. 6.6 N.A. 0 N.A.
P-Site Similarity: 100 100 6.6 80 N.A. 6.6 6.6 N.A. 0 73.3 53.3 60 N.A. 20 N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 49 50.5
Protein Similarity: N.A. N.A. N.A. N.A. 66.8 67.5
P-Site Identity: N.A. N.A. N.A. N.A. 26.6 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 15 8 0 0 8 0 0 0 0 15 8 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 15 8 15 8 8 0 8 0 0 8 0 0 % D
% Glu: 8 8 8 8 8 8 0 8 22 0 0 0 0 15 8 % E
% Phe: 0 0 0 0 0 0 43 15 8 0 0 8 8 0 0 % F
% Gly: 0 0 0 0 8 0 8 0 0 22 0 0 8 0 36 % G
% His: 0 0 0 8 0 0 0 0 0 0 15 15 0 15 0 % H
% Ile: 8 0 43 15 8 0 0 0 0 8 0 0 8 0 8 % I
% Lys: 0 0 0 36 22 0 0 8 0 0 0 0 0 8 15 % K
% Leu: 29 15 0 0 0 0 0 8 43 15 0 8 0 8 0 % L
% Met: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 50 15 8 8 0 0 15 8 0 22 8 8 0 8 % N
% Pro: 8 8 0 0 0 36 22 0 0 15 15 0 43 22 0 % P
% Gln: 15 0 0 0 8 0 0 0 0 0 8 0 0 8 0 % Q
% Arg: 15 8 15 8 0 8 8 8 0 0 15 15 8 15 0 % R
% Ser: 0 8 0 0 36 22 0 36 15 22 15 0 8 0 15 % S
% Thr: 0 0 0 0 0 8 0 0 0 0 8 0 0 8 8 % T
% Val: 8 0 8 0 0 0 0 0 8 0 8 36 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 8 % W
% Tyr: 0 0 0 0 0 8 8 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _