Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCS2 All Species: 9.09
Human Site: S286 Identified Species: 13.33
UniProt: P54868 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54868 NP_005509.1 508 56635 S286 N Q W K Q A G S D R P F T L D
Chimpanzee Pan troglodytes XP_513693 508 56570 S286 N Q W K Q A G S D R P F T L D
Rhesus Macaque Macaca mulatta XP_001114146 508 56631 S286 N Q W K Q A G S D R P F T L D
Dog Lupus familis XP_849878 508 56870 I286 K Q W K Q A G I D R P F T L D
Cat Felis silvestris
Mouse Mus musculus P54869 508 56804 N286 N Q W K Q A G N N Q P F T L D
Rat Rattus norvegicus P22791 508 56893 N286 N Q W K Q A G N N Q P F T L D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521387 594 65294 N372 K I E Q Q W Q N T G I T R P F
Chicken Gallus gallus P23228 522 57541 G298 T A N G V F S G L E A F R D V
Frog Xenopus laevis NP_001080399 520 57209 G298 T E S G V Y V G L D S F R D L
Zebra Danio Brachydanio rerio NP_957379 508 55918 G287 M E S G P F S G L E A F R D V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524711 465 51158 A244 K D T S K Q P A S L S T F D A
Honey Bee Apis mellifera XP_397202 453 50855 K232 Y R K K V I D K Y N H D V T L
Nematode Worm Caenorhab. elegans P54871 462 51397 H241 F I S K V N R H T T G I D G L
Sea Urchin Strong. purpuratus XP_801879 508 56054 L279 V Q K S L A R L V L N D F L H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P54873 461 51076 D240 G K E F S I N D A D Y I V F H
Baker's Yeast Sacchar. cerevisiae P54839 491 54995 I270 K S Y S K K A I S K G L V S D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.2 89.1 N.A. 89.3 88.9 N.A. 64.1 61.6 62.3 61.8 N.A. 55.3 52.7 39.7 57.4
Protein Similarity: 100 99.6 98.4 93.9 N.A. 95 95 N.A. 73 75.6 76.7 75.7 N.A. 67.7 70 55.1 71.6
P-Site Identity: 100 100 100 86.6 N.A. 80 80 N.A. 6.6 6.6 6.6 6.6 N.A. 0 6.6 6.6 20
P-Site Similarity: 100 100 100 86.6 N.A. 100 100 N.A. 20 6.6 13.3 13.3 N.A. 13.3 13.3 6.6 20
Percent
Protein Identity: N.A. N.A. N.A. 42.3 42.1 N.A.
Protein Similarity: N.A. N.A. N.A. 59.4 62.4 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 0 0 44 7 7 7 0 13 0 0 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 0 0 0 0 7 7 25 13 0 13 7 25 44 % D
% Glu: 0 13 13 0 0 0 0 0 0 13 0 0 0 0 0 % E
% Phe: 7 0 0 7 0 13 0 0 0 0 0 57 13 7 7 % F
% Gly: 7 0 0 19 0 0 38 19 0 7 13 0 0 7 0 % G
% His: 0 0 0 0 0 0 0 7 0 0 7 0 0 0 13 % H
% Ile: 0 13 0 0 0 13 0 13 0 0 7 13 0 0 0 % I
% Lys: 25 7 13 50 13 7 0 7 0 7 0 0 0 0 0 % K
% Leu: 0 0 0 0 7 0 0 7 19 13 0 7 0 44 19 % L
% Met: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 32 0 7 0 0 7 7 19 13 7 7 0 0 0 0 % N
% Pro: 0 0 0 0 7 0 7 0 0 0 38 0 0 7 0 % P
% Gln: 0 44 0 7 44 7 7 0 0 13 0 0 0 0 0 % Q
% Arg: 0 7 0 0 0 0 13 0 0 25 0 0 25 0 0 % R
% Ser: 0 7 19 19 7 0 13 19 13 0 13 0 0 7 0 % S
% Thr: 13 0 7 0 0 0 0 0 13 7 0 13 38 7 0 % T
% Val: 7 0 0 0 25 0 7 0 7 0 0 0 19 0 13 % V
% Trp: 0 0 38 0 0 7 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 7 0 0 7 0 0 7 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _