Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCS2 All Species: 21.82
Human Site: S322 Identified Species: 32
UniProt: P54868 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54868 NP_005509.1 508 56635 S322 L M F N D F L S A S S D T Q T
Chimpanzee Pan troglodytes XP_513693 508 56570 S322 L M F N D F L S A S S D T Q T
Rhesus Macaque Macaca mulatta XP_001114146 508 56631 S322 L M F N D F L S A S S D T Q T
Dog Lupus familis XP_849878 508 56870 S322 L M F N D F L S A S S D T Q T
Cat Felis silvestris
Mouse Mus musculus P54869 508 56804 S322 L M F N D F L S S S S D K Q N
Rat Rattus norvegicus P22791 508 56893 S322 L M F N D F L S S S S D K Q N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521387 594 65294 D408 V A R L A F N D F L A G S S G
Chicken Gallus gallus P23228 522 57541 A334 L F N Q K T K A S L L V S N Q
Frog Xenopus laevis NP_001080399 520 57209 A334 I F N E K T K A S L L V S K E
Zebra Danio Brachydanio rerio NP_957379 508 55918 A323 L F D D K T K A S L L I S N Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524711 465 51158 E280 D F L L S S E E E R T K Q F P
Honey Bee Apis mellifera XP_397202 453 50855 L268 R L A F I D F L N T S K E E I
Nematode Worm Caenorhab. elegans P54871 462 51397 Q277 V M N Y T D S Q L R H K Q L N
Sea Urchin Strong. purpuratus XP_801879 508 56054 D315 K L K D T F F D K N V E K A F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P54873 461 51076 A276 N A S S I D E A A K E K F T P
Baker's Yeast Sacchar. cerevisiae P54839 491 54995 S306 T C K L V T K S Y G R L L Y N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.2 89.1 N.A. 89.3 88.9 N.A. 64.1 61.6 62.3 61.8 N.A. 55.3 52.7 39.7 57.4
Protein Similarity: 100 99.6 98.4 93.9 N.A. 95 95 N.A. 73 75.6 76.7 75.7 N.A. 67.7 70 55.1 71.6
P-Site Identity: 100 100 100 100 N.A. 80 80 N.A. 6.6 6.6 0 6.6 N.A. 0 6.6 6.6 6.6
P-Site Similarity: 100 100 100 100 N.A. 86.6 86.6 N.A. 26.6 26.6 33.3 33.3 N.A. 6.6 26.6 13.3 33.3
Percent
Protein Identity: N.A. N.A. N.A. 42.3 42.1 N.A.
Protein Similarity: N.A. N.A. N.A. 59.4 62.4 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 13 7 0 7 0 0 25 32 0 7 0 0 7 0 % A
% Cys: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 7 13 38 19 0 13 0 0 0 38 0 0 0 % D
% Glu: 0 0 0 7 0 0 13 7 7 0 7 7 7 7 7 % E
% Phe: 0 25 38 7 0 50 13 0 7 0 0 0 7 7 7 % F
% Gly: 0 0 0 0 0 0 0 0 0 7 0 7 0 0 7 % G
% His: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % H
% Ile: 7 0 0 0 13 0 0 0 0 0 0 7 0 0 7 % I
% Lys: 7 0 13 0 19 0 25 0 7 7 0 25 19 7 0 % K
% Leu: 50 13 7 19 0 0 38 7 7 25 19 7 7 7 0 % L
% Met: 0 44 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 7 0 19 38 0 0 7 0 7 7 0 0 0 13 25 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13 % P
% Gln: 0 0 0 7 0 0 0 7 0 0 0 0 13 38 13 % Q
% Arg: 7 0 7 0 0 0 0 0 0 13 7 0 0 0 0 % R
% Ser: 0 0 7 7 7 7 7 44 32 38 44 0 25 7 0 % S
% Thr: 7 0 0 0 13 25 0 0 0 7 7 0 25 7 25 % T
% Val: 13 0 0 0 7 0 0 0 0 0 7 13 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 0 0 0 0 7 0 0 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _