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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCS2 All Species: 23.33
Human Site: S325 Identified Species: 34.22
UniProt: P54868 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54868 NP_005509.1 508 56635 S325 N D F L S A S S D T Q T S L Y
Chimpanzee Pan troglodytes XP_513693 508 56570 S325 N D F L S A S S D T Q T S L Y
Rhesus Macaque Macaca mulatta XP_001114146 508 56631 S325 N D F L S A S S D T Q T S L Y
Dog Lupus familis XP_849878 508 56870 S325 N D F L S A S S D T Q T S L Y
Cat Felis silvestris
Mouse Mus musculus P54869 508 56804 S325 N D F L S S S S D K Q N N L Y
Rat Rattus norvegicus P22791 508 56893 S325 N D F L S S S S D K Q N N L Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521387 594 65294 A411 L A F N D F L A G S S G P R N
Chicken Gallus gallus P23228 522 57541 L337 Q K T K A S L L V S N Q N G N
Frog Xenopus laevis NP_001080399 520 57209 L337 E K T K A S L L V S K E N G N
Zebra Danio Brachydanio rerio NP_957379 508 55918 L326 D K T K A S L L I S N Q N G N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524711 465 51158 T283 L S S E E E R T K Q F P D L E
Honey Bee Apis mellifera XP_397202 453 50855 S271 F I D F L N T S K E E I S K K
Nematode Worm Caenorhab. elegans P54871 462 51397 H280 Y T D S Q L R H K Q L N G N G
Sea Urchin Strong. purpuratus XP_801879 508 56054 V318 D T F F D K N V E K A F M T A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P54873 461 51076 E279 S I D E A A K E K F T P Y S S
Baker's Yeast Sacchar. cerevisiae P54839 491 54995 R309 L V T K S Y G R L L Y N D F R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.2 89.1 N.A. 89.3 88.9 N.A. 64.1 61.6 62.3 61.8 N.A. 55.3 52.7 39.7 57.4
Protein Similarity: 100 99.6 98.4 93.9 N.A. 95 95 N.A. 73 75.6 76.7 75.7 N.A. 67.7 70 55.1 71.6
P-Site Identity: 100 100 100 100 N.A. 73.3 73.3 N.A. 6.6 0 0 0 N.A. 6.6 13.3 0 6.6
P-Site Similarity: 100 100 100 100 N.A. 86.6 86.6 N.A. 20 26.6 33.3 33.3 N.A. 13.3 26.6 0 26.6
Percent
Protein Identity: N.A. N.A. N.A. 42.3 42.1 N.A.
Protein Similarity: N.A. N.A. N.A. 59.4 62.4 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 0 25 32 0 7 0 0 7 0 0 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 13 38 19 0 13 0 0 0 38 0 0 0 13 0 0 % D
% Glu: 7 0 0 13 7 7 0 7 7 7 7 7 0 0 7 % E
% Phe: 7 0 50 13 0 7 0 0 0 7 7 7 0 7 0 % F
% Gly: 0 0 0 0 0 0 7 0 7 0 0 7 7 19 7 % G
% His: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % H
% Ile: 0 13 0 0 0 0 0 0 7 0 0 7 0 0 0 % I
% Lys: 0 19 0 25 0 7 7 0 25 19 7 0 0 7 7 % K
% Leu: 19 0 0 38 7 7 25 19 7 7 7 0 0 44 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % M
% Asn: 38 0 0 7 0 7 7 0 0 0 13 25 32 7 25 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 13 7 0 0 % P
% Gln: 7 0 0 0 7 0 0 0 0 13 38 13 0 0 0 % Q
% Arg: 0 0 0 0 0 0 13 7 0 0 0 0 0 7 7 % R
% Ser: 7 7 7 7 44 32 38 44 0 25 7 0 32 7 7 % S
% Thr: 0 13 25 0 0 0 7 7 0 25 7 25 0 7 0 % T
% Val: 0 7 0 0 0 0 0 7 13 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 0 0 0 7 0 0 0 0 7 0 7 0 38 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _