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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCS2 All Species: 31.21
Human Site: S385 Identified Species: 45.78
UniProt: P54868 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54868 NP_005509.1 508 56635 S385 N G N M Y T S S L Y G C L A S
Chimpanzee Pan troglodytes XP_513693 508 56570 S385 N G N M Y T S S L Y G C L A S
Rhesus Macaque Macaca mulatta XP_001114146 508 56631 S385 N G N M Y T S S L Y G C L A S
Dog Lupus familis XP_849878 508 56870 S385 N G N M Y T S S L Y G C L A S
Cat Felis silvestris
Mouse Mus musculus P54869 508 56804 S385 N G N M Y T S S L Y G C L A S
Rat Rattus norvegicus P22791 508 56893 S385 N G N M Y T S S L Y G C L A S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521387 594 65294 Y471 S T H N G N M Y T P S M Y G C
Chicken Gallus gallus P23228 522 57541 S397 T Q D A T P G S A L D K I T A
Frog Xenopus laevis NP_001080399 520 57209 S397 S Q D A M P G S S L D K L T S
Zebra Danio Brachydanio rerio NP_957379 508 55918 S386 T Q D A T P G S A L D K L V S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524711 465 51158 G343 Y T P S V Y S G L V S L L I S
Honey Bee Apis mellifera XP_397202 453 50855 P331 Q V G N M Y T P S V Y S G L A
Nematode Worm Caenorhab. elegans P54871 462 51397 Y340 L F A Q L L A Y L A A D D C V
Sea Urchin Strong. purpuratus XP_801879 508 56054 Y378 K R I A L F S Y G S G M A S S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P54873 461 51076 L339 L Y A A F A S L I H K K H N D
Baker's Yeast Sacchar. cerevisiae P54839 491 54995 T369 S L I V P T N T G N M Y T A S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.2 89.1 N.A. 89.3 88.9 N.A. 64.1 61.6 62.3 61.8 N.A. 55.3 52.7 39.7 57.4
Protein Similarity: 100 99.6 98.4 93.9 N.A. 95 95 N.A. 73 75.6 76.7 75.7 N.A. 67.7 70 55.1 71.6
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 0 6.6 20 20 N.A. 26.6 0 6.6 20
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 13.3 26.6 33.3 26.6 N.A. 26.6 13.3 13.3 26.6
Percent
Protein Identity: N.A. N.A. N.A. 42.3 42.1 N.A.
Protein Similarity: N.A. N.A. N.A. 59.4 62.4 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 20 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 13 32 0 7 7 0 13 7 7 0 7 44 13 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 38 0 7 7 % C
% Asp: 0 0 19 0 0 0 0 0 0 0 19 7 7 0 7 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 7 0 0 7 7 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 38 7 0 7 0 19 7 13 0 44 0 7 7 0 % G
% His: 0 0 7 0 0 0 0 0 0 7 0 0 7 0 0 % H
% Ile: 0 0 13 0 0 0 0 0 7 0 0 0 7 7 0 % I
% Lys: 7 0 0 0 0 0 0 0 0 0 7 25 0 0 0 % K
% Leu: 13 7 0 0 13 7 0 7 50 19 0 7 57 7 0 % L
% Met: 0 0 0 38 13 0 7 0 0 0 7 13 0 0 0 % M
% Asn: 38 0 38 13 0 7 7 0 0 7 0 0 0 7 0 % N
% Pro: 0 0 7 0 7 19 0 7 0 7 0 0 0 0 0 % P
% Gln: 7 19 0 7 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 19 0 0 7 0 0 57 57 13 7 13 7 0 7 69 % S
% Thr: 13 13 0 0 13 44 7 7 7 0 0 0 7 13 0 % T
% Val: 0 7 0 7 7 0 0 0 0 13 0 0 0 7 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 7 0 0 38 13 0 19 0 38 7 7 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _