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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCS2 All Species: 27.58
Human Site: S433 Identified Species: 40.44
UniProt: P54868 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54868 NP_005509.1 508 56635 S433 S Q D A A P G S P L D K L V S
Chimpanzee Pan troglodytes XP_513693 508 56570 S433 S Q D A A P G S P L D K L V S
Rhesus Macaque Macaca mulatta XP_001114146 508 56631 S433 S Q D A S P G S P L D K L V S
Dog Lupus familis XP_849878 508 56870 S433 S Q D A S P G S P L E K L V S
Cat Felis silvestris
Mouse Mus musculus P54869 508 56804 S433 S K D A S P G S P L E K L V S
Rat Rattus norvegicus P22791 508 56893 S433 S K D A S P G S P L E K L V S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521387 594 65294 A519 L R V S Q D A A K G S S L D K
Chicken Gallus gallus P23228 522 57541 S445 A N Y I P Q C S V E D L F E G
Frog Xenopus laevis NP_001080399 520 57209 S445 A N Y I P Q G S V D D L F P G
Zebra Danio Brachydanio rerio NP_957379 508 55918 S434 A N Y I P Q G S V D E L F P G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524711 465 51158 S391 A A F E K F V S Q L D Y V Q P
Honey Bee Apis mellifera XP_397202 453 50855 K379 I T K D Y N E K S D L V K I T
Nematode Worm Caenorhab. elegans P54871 462 51397 I388 R Q V A I R A I K R L D D R I
Sea Urchin Strong. purpuratus XP_801879 508 56054 F426 R C V K P G V F A D T M K L R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P54873 461 51076 D387 S N I A S V M D V G G K L K A
Baker's Yeast Sacchar. cerevisiae P54839 491 54995 V417 S L Y S C K I V G D V Q H I I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.2 89.1 N.A. 89.3 88.9 N.A. 64.1 61.6 62.3 61.8 N.A. 55.3 52.7 39.7 57.4
Protein Similarity: 100 99.6 98.4 93.9 N.A. 95 95 N.A. 73 75.6 76.7 75.7 N.A. 67.7 70 55.1 71.6
P-Site Identity: 100 100 93.3 86.6 N.A. 80 80 N.A. 6.6 13.3 20 13.3 N.A. 20 0 13.3 0
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 26.6 20 26.6 26.6 N.A. 33.3 13.3 13.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. 42.3 42.1 N.A.
Protein Similarity: N.A. N.A. N.A. 59.4 62.4 N.A.
P-Site Identity: N.A. N.A. N.A. 26.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 40 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 25 7 0 50 13 0 13 7 7 0 0 0 0 0 7 % A
% Cys: 0 7 0 0 7 0 7 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 38 7 0 7 0 7 0 32 38 7 7 7 0 % D
% Glu: 0 0 0 7 0 0 7 0 0 7 25 0 0 7 0 % E
% Phe: 0 0 7 0 0 7 0 7 0 0 0 0 19 0 0 % F
% Gly: 0 0 0 0 0 7 50 0 7 13 7 0 0 0 19 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % H
% Ile: 7 0 7 19 7 0 7 7 0 0 0 0 0 13 13 % I
% Lys: 0 13 7 7 7 7 0 7 13 0 0 44 13 7 7 % K
% Leu: 7 7 0 0 0 0 0 0 0 44 13 19 50 7 0 % L
% Met: 0 0 0 0 0 0 7 0 0 0 0 7 0 0 0 % M
% Asn: 0 25 0 0 0 7 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 25 38 0 0 38 0 0 0 0 13 7 % P
% Gln: 0 32 0 0 7 19 0 0 7 0 0 7 0 7 0 % Q
% Arg: 13 7 0 0 0 7 0 0 0 7 0 0 0 7 7 % R
% Ser: 50 0 0 13 32 0 0 63 7 0 7 7 0 0 38 % S
% Thr: 0 7 0 0 0 0 0 0 0 0 7 0 0 0 7 % T
% Val: 0 0 19 0 0 7 13 7 25 0 7 7 7 38 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 25 0 7 0 0 0 0 0 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _