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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCS2 All Species: 22.12
Human Site: S451 Identified Species: 32.44
UniProt: P54868 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54868 NP_005509.1 508 56635 S451 D L P K R L A S R K C V S P E
Chimpanzee Pan troglodytes XP_513693 508 56570 S451 D L P K R L A S R K C V S P E
Rhesus Macaque Macaca mulatta XP_001114146 508 56631 S451 D L P K R L A S R K C M S P E
Dog Lupus familis XP_849878 508 56870 S451 D L P K R L A S R K R M S P Q
Cat Felis silvestris
Mouse Mus musculus P54869 508 56804 S451 D L P K R L D S R R R M S P E
Rat Rattus norvegicus P22791 508 56893 S451 D L P K R L D S R R R M S P E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521387 594 65294 T537 S L T D L E S T I S S R R S R
Chicken Gallus gallus P23228 522 57541 H463 L V R V D E K H R R T Y A R R
Frog Xenopus laevis NP_001080399 520 57209 H463 L V R V D E K H R R F Y A R S
Zebra Danio Brachydanio rerio NP_957379 508 55918 H452 L T R V D E K H R R Q Y A R R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524711 465 51158 E409 S R E K V A P E Q F S A L M E
Honey Bee Apis mellifera XP_397202 453 50855 D397 S Y I K Q Q L D A R Q K I S P
Nematode Worm Caenorhab. elegans P54871 462 51397 L406 P E E F T E T L Q K R E V F L
Sea Urchin Strong. purpuratus XP_801879 508 56054 P444 H H L A K Y T P Q G S I E D L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P54873 461 51076 E405 Y A P E K F V E T M K L M E H
Baker's Yeast Sacchar. cerevisiae P54839 491 54995 K435 D I T N K L A K R I T E T P K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.2 89.1 N.A. 89.3 88.9 N.A. 64.1 61.6 62.3 61.8 N.A. 55.3 52.7 39.7 57.4
Protein Similarity: 100 99.6 98.4 93.9 N.A. 95 95 N.A. 73 75.6 76.7 75.7 N.A. 67.7 70 55.1 71.6
P-Site Identity: 100 100 93.3 80 N.A. 73.3 73.3 N.A. 6.6 6.6 6.6 6.6 N.A. 13.3 6.6 6.6 0
P-Site Similarity: 100 100 100 93.3 N.A. 86.6 86.6 N.A. 20 26.6 26.6 20 N.A. 20 20 13.3 20
Percent
Protein Identity: N.A. N.A. N.A. 42.3 42.1 N.A.
Protein Similarity: N.A. N.A. N.A. 59.4 62.4 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 33.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 7 0 7 32 0 7 0 0 7 19 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 19 0 0 0 0 % C
% Asp: 44 0 0 7 19 0 13 7 0 0 0 0 0 7 0 % D
% Glu: 0 7 13 7 0 32 0 13 0 0 0 13 7 7 38 % E
% Phe: 0 0 0 7 0 7 0 0 0 7 7 0 0 7 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % G
% His: 7 7 0 0 0 0 0 19 0 0 0 0 0 0 7 % H
% Ile: 0 7 7 0 0 0 0 0 7 7 0 7 7 0 0 % I
% Lys: 0 0 0 50 19 0 19 7 0 32 7 7 0 0 7 % K
% Leu: 19 44 7 0 7 44 7 7 0 0 0 7 7 0 13 % L
% Met: 0 0 0 0 0 0 0 0 0 7 0 25 7 7 0 % M
% Asn: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 7 0 44 0 0 0 7 7 0 0 0 0 0 44 7 % P
% Gln: 0 0 0 0 7 7 0 0 19 0 13 0 0 0 7 % Q
% Arg: 0 7 19 0 38 0 0 0 63 38 25 7 7 19 19 % R
% Ser: 19 0 0 0 0 0 7 38 0 7 19 0 38 13 7 % S
% Thr: 0 7 13 0 7 0 13 7 7 0 13 0 7 0 0 % T
% Val: 0 13 0 19 7 0 7 0 0 0 0 13 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 7 0 0 0 7 0 0 0 0 0 19 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _