Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCS2 All Species: 23.64
Human Site: S456 Identified Species: 34.67
UniProt: P54868 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54868 NP_005509.1 508 56635 S456 L A S R K C V S P E E F T E I
Chimpanzee Pan troglodytes XP_513693 508 56570 S456 L A S R K C V S P E E F T E I
Rhesus Macaque Macaca mulatta XP_001114146 508 56631 S456 L A S R K C M S P E E F T E I
Dog Lupus familis XP_849878 508 56870 S456 L A S R K R M S P Q E F T E I
Cat Felis silvestris
Mouse Mus musculus P54869 508 56804 S456 L D S R R R M S P E E F T E I
Rat Rattus norvegicus P22791 508 56893 S456 L D S R R R M S P E E F T E I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521387 594 65294 R542 E S T I S S R R S R E P R R E
Chicken Gallus gallus P23228 522 57541 A468 E K H R R T Y A R R P V M G D
Frog Xenopus laevis NP_001080399 520 57209 A468 E K H R R F Y A R S S L M S D
Zebra Danio Brachydanio rerio NP_957379 508 55918 A457 E K H R R Q Y A R R S M N D D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524711 465 51158 L414 A P E Q F S A L M E V R E K N
Honey Bee Apis mellifera XP_397202 453 50855 I402 Q L D A R Q K I S P A D Y T K
Nematode Worm Caenorhab. elegans P54871 462 51397 V411 E T L Q K R E V F L R S K E I
Sea Urchin Strong. purpuratus XP_801879 508 56054 E449 Y T P Q G S I E D L F P G T W
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P54873 461 51076 M410 F V E T M K L M E H R Y G A K
Baker's Yeast Sacchar. cerevisiae P54839 491 54995 T440 L A K R I T E T P K D Y E A A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.2 89.1 N.A. 89.3 88.9 N.A. 64.1 61.6 62.3 61.8 N.A. 55.3 52.7 39.7 57.4
Protein Similarity: 100 99.6 98.4 93.9 N.A. 95 95 N.A. 73 75.6 76.7 75.7 N.A. 67.7 70 55.1 71.6
P-Site Identity: 100 100 93.3 80 N.A. 73.3 73.3 N.A. 6.6 6.6 6.6 6.6 N.A. 6.6 0 20 0
P-Site Similarity: 100 100 100 93.3 N.A. 86.6 86.6 N.A. 20 20 20 26.6 N.A. 20 6.6 26.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. 42.3 42.1 N.A.
Protein Similarity: N.A. N.A. N.A. 59.4 62.4 N.A.
P-Site Identity: N.A. N.A. N.A. 0 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 32 0 7 0 0 7 19 0 0 7 0 0 13 7 % A
% Cys: 0 0 0 0 0 19 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 13 7 0 0 0 0 0 7 0 7 7 0 7 19 % D
% Glu: 32 0 13 0 0 0 13 7 7 38 44 0 13 44 7 % E
% Phe: 7 0 0 0 7 7 0 0 7 0 7 38 0 0 0 % F
% Gly: 0 0 0 0 7 0 0 0 0 0 0 0 13 7 0 % G
% His: 0 0 19 0 0 0 0 0 0 7 0 0 0 0 0 % H
% Ile: 0 0 0 7 7 0 7 7 0 0 0 0 0 0 44 % I
% Lys: 0 19 7 0 32 7 7 0 0 7 0 0 7 7 13 % K
% Leu: 44 7 7 0 0 0 7 7 0 13 0 7 0 0 0 % L
% Met: 0 0 0 0 7 0 25 7 7 0 0 7 13 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 7 % N
% Pro: 0 7 7 0 0 0 0 0 44 7 7 13 0 0 0 % P
% Gln: 7 0 0 19 0 13 0 0 0 7 0 0 0 0 0 % Q
% Arg: 0 0 0 63 38 25 7 7 19 19 13 7 7 7 0 % R
% Ser: 0 7 38 0 7 19 0 38 13 7 13 7 0 7 0 % S
% Thr: 0 13 7 7 0 13 0 7 0 0 0 0 38 13 0 % T
% Val: 0 7 0 0 0 0 13 7 0 0 7 7 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % W
% Tyr: 7 0 0 0 0 0 19 0 0 0 0 13 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _