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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCS2 All Species: 27.58
Human Site: S477 Identified Species: 40.44
UniProt: P54868 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54868 NP_005509.1 508 56635 S477 F Y H K V N F S P P G D T N S
Chimpanzee Pan troglodytes XP_513693 508 56570 S477 F Y H K V N F S P P G D T N S
Rhesus Macaque Macaca mulatta XP_001114146 508 56631 S477 F Y H K A N F S P P G D T N S
Dog Lupus familis XP_849878 508 56870 S477 F Y H K V N F S P P G D T S S
Cat Felis silvestris
Mouse Mus musculus P54869 508 56804 S477 F Y H K V N F S P P G D T S N
Rat Rattus norvegicus P22791 508 56893 S477 F Y H K V N F S P P G D T S N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521387 594 65294 S563 G P R E M D F S P P G D K D I
Chicken Gallus gallus P23228 522 57541 I489 V E V V H P G I V H E H I P S
Frog Xenopus laevis NP_001080399 520 57209 T489 P E S V L A S T A N E H F P S
Zebra Danio Brachydanio rerio NP_957379 508 55918 A478 L V S S S M A A E H I P S P L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524711 465 51158 A435 T P T G S I S A L F P G T Y Y
Honey Bee Apis mellifera XP_397202 453 50855 Y423 Q N C H T V P Y T P Q S N I K
Nematode Worm Caenorhab. elegans P54871 462 51397 Y432 T S L F P N T Y F L D N M D K
Sea Urchin Strong. purpuratus XP_801879 508 56054 N470 E M Q R R Q Y N R S S V S Q Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P54873 461 51076 A431 E G I I D L L A P G T Y Y L K
Baker's Yeast Sacchar. cerevisiae P54839 491 54995 K461 A H L K K N F K P Q G S I E H
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.2 89.1 N.A. 89.3 88.9 N.A. 64.1 61.6 62.3 61.8 N.A. 55.3 52.7 39.7 57.4
Protein Similarity: 100 99.6 98.4 93.9 N.A. 95 95 N.A. 73 75.6 76.7 75.7 N.A. 67.7 70 55.1 71.6
P-Site Identity: 100 100 93.3 93.3 N.A. 86.6 86.6 N.A. 40 6.6 6.6 0 N.A. 6.6 6.6 6.6 0
P-Site Similarity: 100 100 93.3 100 N.A. 100 100 N.A. 66.6 6.6 20 13.3 N.A. 13.3 6.6 20 26.6
Percent
Protein Identity: N.A. N.A. N.A. 42.3 42.1 N.A.
Protein Similarity: N.A. N.A. N.A. 59.4 62.4 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 33.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 7 7 7 19 7 0 0 0 0 0 0 % A
% Cys: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 7 7 0 0 0 0 7 44 0 13 0 % D
% Glu: 13 13 0 7 0 0 0 0 7 0 13 0 0 7 0 % E
% Phe: 38 0 0 7 0 0 50 0 7 7 0 0 7 0 0 % F
% Gly: 7 7 0 7 0 0 7 0 0 7 50 7 0 0 0 % G
% His: 0 7 38 7 7 0 0 0 0 13 0 13 0 0 7 % H
% Ile: 0 0 7 7 0 7 0 7 0 0 7 0 13 7 7 % I
% Lys: 0 0 0 44 7 0 0 7 0 0 0 0 7 0 19 % K
% Leu: 7 0 13 0 7 7 7 0 7 7 0 0 0 7 7 % L
% Met: 0 7 0 0 7 7 0 0 0 0 0 0 7 0 0 % M
% Asn: 0 7 0 0 0 50 0 7 0 7 0 7 7 19 13 % N
% Pro: 7 13 0 0 7 7 7 0 57 50 7 7 0 19 0 % P
% Gln: 7 0 7 0 0 7 0 0 0 7 7 0 0 7 7 % Q
% Arg: 0 0 7 7 7 0 0 0 7 0 0 0 0 0 0 % R
% Ser: 0 7 13 7 13 0 13 44 0 7 7 13 13 19 38 % S
% Thr: 13 0 7 0 7 0 7 7 7 0 7 0 44 0 0 % T
% Val: 7 7 7 13 32 7 0 0 7 0 0 7 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 38 0 0 0 0 7 13 0 0 0 7 7 7 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _