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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCS2
All Species:
27.58
Human Site:
S477
Identified Species:
40.44
UniProt:
P54868
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54868
NP_005509.1
508
56635
S477
F
Y
H
K
V
N
F
S
P
P
G
D
T
N
S
Chimpanzee
Pan troglodytes
XP_513693
508
56570
S477
F
Y
H
K
V
N
F
S
P
P
G
D
T
N
S
Rhesus Macaque
Macaca mulatta
XP_001114146
508
56631
S477
F
Y
H
K
A
N
F
S
P
P
G
D
T
N
S
Dog
Lupus familis
XP_849878
508
56870
S477
F
Y
H
K
V
N
F
S
P
P
G
D
T
S
S
Cat
Felis silvestris
Mouse
Mus musculus
P54869
508
56804
S477
F
Y
H
K
V
N
F
S
P
P
G
D
T
S
N
Rat
Rattus norvegicus
P22791
508
56893
S477
F
Y
H
K
V
N
F
S
P
P
G
D
T
S
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521387
594
65294
S563
G
P
R
E
M
D
F
S
P
P
G
D
K
D
I
Chicken
Gallus gallus
P23228
522
57541
I489
V
E
V
V
H
P
G
I
V
H
E
H
I
P
S
Frog
Xenopus laevis
NP_001080399
520
57209
T489
P
E
S
V
L
A
S
T
A
N
E
H
F
P
S
Zebra Danio
Brachydanio rerio
NP_957379
508
55918
A478
L
V
S
S
S
M
A
A
E
H
I
P
S
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524711
465
51158
A435
T
P
T
G
S
I
S
A
L
F
P
G
T
Y
Y
Honey Bee
Apis mellifera
XP_397202
453
50855
Y423
Q
N
C
H
T
V
P
Y
T
P
Q
S
N
I
K
Nematode Worm
Caenorhab. elegans
P54871
462
51397
Y432
T
S
L
F
P
N
T
Y
F
L
D
N
M
D
K
Sea Urchin
Strong. purpuratus
XP_801879
508
56054
N470
E
M
Q
R
R
Q
Y
N
R
S
S
V
S
Q
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54873
461
51076
A431
E
G
I
I
D
L
L
A
P
G
T
Y
Y
L
K
Baker's Yeast
Sacchar. cerevisiae
P54839
491
54995
K461
A
H
L
K
K
N
F
K
P
Q
G
S
I
E
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.2
89.1
N.A.
89.3
88.9
N.A.
64.1
61.6
62.3
61.8
N.A.
55.3
52.7
39.7
57.4
Protein Similarity:
100
99.6
98.4
93.9
N.A.
95
95
N.A.
73
75.6
76.7
75.7
N.A.
67.7
70
55.1
71.6
P-Site Identity:
100
100
93.3
93.3
N.A.
86.6
86.6
N.A.
40
6.6
6.6
0
N.A.
6.6
6.6
6.6
0
P-Site Similarity:
100
100
93.3
100
N.A.
100
100
N.A.
66.6
6.6
20
13.3
N.A.
13.3
6.6
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.3
42.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.4
62.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
7
7
7
19
7
0
0
0
0
0
0
% A
% Cys:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
7
7
0
0
0
0
7
44
0
13
0
% D
% Glu:
13
13
0
7
0
0
0
0
7
0
13
0
0
7
0
% E
% Phe:
38
0
0
7
0
0
50
0
7
7
0
0
7
0
0
% F
% Gly:
7
7
0
7
0
0
7
0
0
7
50
7
0
0
0
% G
% His:
0
7
38
7
7
0
0
0
0
13
0
13
0
0
7
% H
% Ile:
0
0
7
7
0
7
0
7
0
0
7
0
13
7
7
% I
% Lys:
0
0
0
44
7
0
0
7
0
0
0
0
7
0
19
% K
% Leu:
7
0
13
0
7
7
7
0
7
7
0
0
0
7
7
% L
% Met:
0
7
0
0
7
7
0
0
0
0
0
0
7
0
0
% M
% Asn:
0
7
0
0
0
50
0
7
0
7
0
7
7
19
13
% N
% Pro:
7
13
0
0
7
7
7
0
57
50
7
7
0
19
0
% P
% Gln:
7
0
7
0
0
7
0
0
0
7
7
0
0
7
7
% Q
% Arg:
0
0
7
7
7
0
0
0
7
0
0
0
0
0
0
% R
% Ser:
0
7
13
7
13
0
13
44
0
7
7
13
13
19
38
% S
% Thr:
13
0
7
0
7
0
7
7
7
0
7
0
44
0
0
% T
% Val:
7
7
7
13
32
7
0
0
7
0
0
7
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
38
0
0
0
0
7
13
0
0
0
7
7
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _