Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCS2 All Species: 22.73
Human Site: T233 Identified Species: 33.33
UniProt: P54868 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54868 NP_005509.1 508 56635 T233 L E R G L R G T H M E N V Y D
Chimpanzee Pan troglodytes XP_513693 508 56570 T233 L E R G L R G T H M E N A Y D
Rhesus Macaque Macaca mulatta XP_001114146 508 56631 T233 L E R G L R G T H M E N V Y D
Dog Lupus familis XP_849878 508 56870 T233 L E R G L R G T H M E N V Y D
Cat Felis silvestris
Mouse Mus musculus P54869 508 56804 T233 L E Q G L R G T H M E N A Y D
Rat Rattus norvegicus P22791 508 56893 T233 L E Q G L R G T H M E N A Y D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521387 594 65294 L319 P L A L E R G L R G T H M E N
Chicken Gallus gallus P23228 522 57541 Q245 N K I H A Q W Q K E G T D R G
Frog Xenopus laevis NP_001080399 520 57209 Q245 K K I H A Q W Q K E G T D K P
Zebra Danio Brachydanio rerio NP_957379 508 55918 Q234 N K I H A R W Q R E G T E G R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524711 465 51158 E191 G L R A T H M E H A Y D F Y K
Honey Bee Apis mellifera XP_397202 453 50855 D179 P N A P L I I D R G V R S S C
Nematode Worm Caenorhab. elegans P54871 462 51397 Q188 A S I P I D R Q F S A C H M K
Sea Urchin Strong. purpuratus XP_801879 508 56054 Y226 G K L S I Q C Y L G A L D K C
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P54873 461 51076 A187 K L R A S H M A H V Y D F Y K
Baker's Yeast Sacchar. cerevisiae P54839 491 54995 I217 W I G P D A P I V F D S V R A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.2 89.1 N.A. 89.3 88.9 N.A. 64.1 61.6 62.3 61.8 N.A. 55.3 52.7 39.7 57.4
Protein Similarity: 100 99.6 98.4 93.9 N.A. 95 95 N.A. 73 75.6 76.7 75.7 N.A. 67.7 70 55.1 71.6
P-Site Identity: 100 93.3 100 100 N.A. 86.6 86.6 N.A. 13.3 0 0 6.6 N.A. 20 6.6 0 0
P-Site Similarity: 100 93.3 100 100 N.A. 93.3 93.3 N.A. 33.3 13.3 13.3 13.3 N.A. 26.6 6.6 6.6 20
Percent
Protein Identity: N.A. N.A. N.A. 42.3 42.1 N.A.
Protein Similarity: N.A. N.A. N.A. 59.4 62.4 N.A.
P-Site Identity: N.A. N.A. N.A. 20 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 13 13 19 7 0 7 0 7 13 0 19 0 7 % A
% Cys: 0 0 0 0 0 0 7 0 0 0 0 7 0 0 13 % C
% Asp: 0 0 0 0 7 7 0 7 0 0 7 13 19 0 38 % D
% Glu: 0 38 0 0 7 0 0 7 0 19 38 0 7 7 0 % E
% Phe: 0 0 0 0 0 0 0 0 7 7 0 0 13 0 0 % F
% Gly: 13 0 7 38 0 0 44 0 0 19 19 0 0 7 7 % G
% His: 0 0 0 19 0 13 0 0 50 0 0 7 7 0 0 % H
% Ile: 0 7 25 0 13 7 7 7 0 0 0 0 0 0 0 % I
% Lys: 13 25 0 0 0 0 0 0 13 0 0 0 0 13 19 % K
% Leu: 38 19 7 7 44 0 0 7 7 0 0 7 0 0 0 % L
% Met: 0 0 0 0 0 0 13 0 0 38 0 0 7 7 0 % M
% Asn: 13 7 0 0 0 0 0 0 0 0 0 38 0 0 7 % N
% Pro: 13 0 0 19 0 0 7 0 0 0 0 0 0 0 7 % P
% Gln: 0 0 13 0 0 19 0 25 0 0 0 0 0 0 0 % Q
% Arg: 0 0 38 0 0 50 7 0 19 0 0 7 0 13 7 % R
% Ser: 0 7 0 7 7 0 0 0 0 7 0 7 7 7 0 % S
% Thr: 0 0 0 0 7 0 0 38 0 0 7 19 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 7 7 7 0 25 0 0 % V
% Trp: 7 0 0 0 0 0 19 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 7 0 0 13 0 0 50 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _