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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCS2
All Species:
22.42
Human Site:
T291
Identified Species:
32.89
UniProt:
P54868
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54868
NP_005509.1
508
56635
T291
A
G
S
D
R
P
F
T
L
D
D
L
Q
Y
M
Chimpanzee
Pan troglodytes
XP_513693
508
56570
T291
A
G
S
D
R
P
F
T
L
D
D
L
Q
Y
M
Rhesus Macaque
Macaca mulatta
XP_001114146
508
56631
T291
A
G
S
D
R
P
F
T
L
D
D
L
Q
Y
M
Dog
Lupus familis
XP_849878
508
56870
T291
A
G
I
D
R
P
F
T
L
D
D
L
Q
F
M
Cat
Felis silvestris
Mouse
Mus musculus
P54869
508
56804
T291
A
G
N
N
Q
P
F
T
L
D
D
V
Q
Y
M
Rat
Rattus norvegicus
P22791
508
56893
T291
A
G
N
N
Q
P
F
T
L
D
D
V
Q
Y
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521387
594
65294
R377
W
Q
N
T
G
I
T
R
P
F
T
L
D
D
F
Chicken
Gallus gallus
P23228
522
57541
R303
F
S
G
L
E
A
F
R
D
V
K
L
E
D
T
Frog
Xenopus laevis
NP_001080399
520
57209
R303
Y
V
G
L
D
S
F
R
D
L
K
L
E
E
T
Zebra Danio
Brachydanio rerio
NP_957379
508
55918
R292
F
S
G
L
E
A
F
R
D
V
K
I
E
D
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524711
465
51158
F249
Q
P
A
S
L
S
T
F
D
A
I
L
F
H
T
Honey Bee
Apis mellifera
XP_397202
453
50855
V237
I
D
K
Y
N
H
D
V
T
L
D
N
F
D
S
Nematode Worm
Caenorhab. elegans
P54871
462
51397
D246
N
R
H
T
T
G
I
D
G
L
N
S
F
D
G
Sea Urchin
Strong. purpuratus
XP_801879
508
56054
F284
A
R
L
V
L
N
D
F
L
H
D
P
S
P
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54873
461
51076
V245
I
N
D
A
D
Y
I
V
F
H
S
P
Y
N
K
Baker's Yeast
Sacchar. cerevisiae
P54839
491
54995
V275
K
A
I
S
K
G
L
V
S
D
P
A
G
S
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.2
89.1
N.A.
89.3
88.9
N.A.
64.1
61.6
62.3
61.8
N.A.
55.3
52.7
39.7
57.4
Protein Similarity:
100
99.6
98.4
93.9
N.A.
95
95
N.A.
73
75.6
76.7
75.7
N.A.
67.7
70
55.1
71.6
P-Site Identity:
100
100
100
86.6
N.A.
73.3
73.3
N.A.
6.6
13.3
13.3
6.6
N.A.
6.6
6.6
0
20
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
13.3
20
20
20
N.A.
20
6.6
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.3
42.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.4
62.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
44
7
7
7
0
13
0
0
0
7
0
7
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
7
25
13
0
13
7
25
44
50
0
7
32
13
% D
% Glu:
0
0
0
0
13
0
0
0
0
0
0
0
19
7
0
% E
% Phe:
13
0
0
0
0
0
57
13
7
7
0
0
19
7
7
% F
% Gly:
0
38
19
0
7
13
0
0
7
0
0
0
7
0
7
% G
% His:
0
0
7
0
0
7
0
0
0
13
0
0
0
7
0
% H
% Ile:
13
0
13
0
0
7
13
0
0
0
7
7
0
0
0
% I
% Lys:
7
0
7
0
7
0
0
0
0
0
19
0
0
0
7
% K
% Leu:
0
0
7
19
13
0
7
0
44
19
0
50
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
38
% M
% Asn:
7
7
19
13
7
7
0
0
0
0
7
7
0
7
0
% N
% Pro:
0
7
0
0
0
38
0
0
7
0
7
13
0
7
0
% P
% Gln:
7
7
0
0
13
0
0
0
0
0
0
0
38
0
0
% Q
% Arg:
0
13
0
0
25
0
0
25
0
0
0
0
0
0
0
% R
% Ser:
0
13
19
13
0
13
0
0
7
0
7
7
7
7
7
% S
% Thr:
0
0
0
13
7
0
13
38
7
0
7
0
0
0
25
% T
% Val:
0
7
0
7
0
0
0
19
0
13
0
13
0
0
0
% V
% Trp:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
7
0
7
0
0
0
0
0
0
7
32
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _