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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCS2
All Species:
21.52
Human Site:
T346
Identified Species:
31.56
UniProt:
P54868
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54868
NP_005509.1
508
56635
T346
G
G
L
K
L
E
D
T
Y
T
N
K
D
L
D
Chimpanzee
Pan troglodytes
XP_513693
508
56570
T346
G
G
L
K
L
E
D
T
Y
T
N
K
D
L
D
Rhesus Macaque
Macaca mulatta
XP_001114146
508
56631
T346
R
G
L
K
L
E
D
T
Y
T
N
K
D
L
D
Dog
Lupus familis
XP_849878
508
56870
T346
R
G
L
K
L
E
D
T
Y
T
N
K
D
M
D
Cat
Felis silvestris
Mouse
Mus musculus
P54869
508
56804
T346
R
G
L
K
L
E
E
T
Y
T
N
K
D
V
D
Rat
Rattus norvegicus
P22791
508
56893
T346
K
G
L
K
L
E
E
T
Y
T
N
K
D
V
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521387
594
65294
L432
E
A
F
R
Q
L
K
L
E
D
T
Y
F
N
K
Chicken
Gallus gallus
P23228
522
57541
L358
Y
G
C
L
A
S
L
L
A
Q
Y
S
P
E
H
Frog
Xenopus laevis
NP_001080399
520
57209
L358
Y
G
C
L
A
S
V
L
A
Q
Y
S
P
Q
Q
Zebra Danio
Brachydanio rerio
NP_957379
508
55918
L347
Y
G
C
L
A
S
V
L
A
Q
H
T
P
Q
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524711
465
51158
R304
L
E
S
T
Y
F
D
R
D
V
E
K
A
F
M
Honey Bee
Apis mellifera
XP_397202
453
50855
E292
F
H
G
I
K
L
E
E
T
Y
L
N
K
D
I
Nematode Worm
Caenorhab. elegans
P54871
462
51397
A301
E
N
D
R
A
G
L
A
K
M
I
E
L
S
A
Sea Urchin
Strong. purpuratus
XP_801879
508
56054
R339
Q
K
T
H
P
S
L
R
L
A
N
Q
V
G
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54873
461
51076
K300
Y
Q
S
R
D
L
E
K
V
S
Q
Q
I
A
K
Baker's Yeast
Sacchar. cerevisiae
P54839
491
54995
A330
P
E
V
D
A
E
L
A
T
R
D
Y
D
E
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.2
89.1
N.A.
89.3
88.9
N.A.
64.1
61.6
62.3
61.8
N.A.
55.3
52.7
39.7
57.4
Protein Similarity:
100
99.6
98.4
93.9
N.A.
95
95
N.A.
73
75.6
76.7
75.7
N.A.
67.7
70
55.1
71.6
P-Site Identity:
100
100
93.3
86.6
N.A.
80
80
N.A.
0
6.6
6.6
6.6
N.A.
13.3
0
0
6.6
P-Site Similarity:
100
100
93.3
93.3
N.A.
93.3
93.3
N.A.
6.6
6.6
6.6
13.3
N.A.
13.3
6.6
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.3
42.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.4
62.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
32
0
0
13
19
7
0
0
7
7
7
% A
% Cys:
0
0
19
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
7
7
0
32
0
7
7
7
0
44
7
38
% D
% Glu:
13
13
0
0
0
44
25
7
7
0
7
7
0
13
0
% E
% Phe:
7
0
7
0
0
7
0
0
0
0
0
0
7
7
0
% F
% Gly:
13
57
7
0
0
7
0
0
0
0
0
0
0
7
0
% G
% His:
0
7
0
7
0
0
0
0
0
0
7
0
0
0
7
% H
% Ile:
0
0
0
7
0
0
0
0
0
0
7
0
7
0
7
% I
% Lys:
7
7
0
38
7
0
7
7
7
0
0
44
7
0
13
% K
% Leu:
7
0
38
19
38
19
25
25
7
0
7
0
7
19
0
% L
% Met:
0
0
0
0
0
0
0
0
0
7
0
0
0
7
7
% M
% Asn:
0
7
0
0
0
0
0
0
0
0
44
7
0
7
7
% N
% Pro:
7
0
0
0
7
0
0
0
0
0
0
0
19
0
0
% P
% Gln:
7
7
0
0
7
0
0
0
0
19
7
13
0
13
13
% Q
% Arg:
19
0
0
19
0
0
0
13
0
7
0
0
0
0
0
% R
% Ser:
0
0
13
0
0
25
0
0
0
7
0
13
0
7
7
% S
% Thr:
0
0
7
7
0
0
0
38
13
38
7
7
0
0
0
% T
% Val:
0
0
7
0
0
0
13
0
7
7
0
0
7
13
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
25
0
0
0
7
0
0
0
38
7
13
13
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _