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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCS2 All Species: 24.55
Human Site: T348 Identified Species: 36
UniProt: P54868 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54868 NP_005509.1 508 56635 T348 L K L E D T Y T N K D L D K A
Chimpanzee Pan troglodytes XP_513693 508 56570 T348 L K L E D T Y T N K D L D K A
Rhesus Macaque Macaca mulatta XP_001114146 508 56631 T348 L K L E D T Y T N K D L D K A
Dog Lupus familis XP_849878 508 56870 T348 L K L E D T Y T N K D M D K A
Cat Felis silvestris
Mouse Mus musculus P54869 508 56804 T348 L K L E E T Y T N K D V D K A
Rat Rattus norvegicus P22791 508 56893 T348 L K L E E T Y T N K D V D K A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521387 594 65294 D434 F R Q L K L E D T Y F N K D V
Chicken Gallus gallus P23228 522 57541 Q360 C L A S L L A Q Y S P E H L A
Frog Xenopus laevis NP_001080399 520 57209 Q360 C L A S V L A Q Y S P Q Q L A
Zebra Danio Brachydanio rerio NP_957379 508 55918 Q349 C L A S V L A Q H T P Q Q L A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524711 465 51158 V306 S T Y F D R D V E K A F M T Q
Honey Bee Apis mellifera XP_397202 453 50855 Y294 G I K L E E T Y L N K D I E K
Nematode Worm Caenorhab. elegans P54871 462 51397 M303 D R A G L A K M I E L S A Q V
Sea Urchin Strong. purpuratus XP_801879 508 56054 A341 T H P S L R L A N Q V G N M Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P54873 461 51076 S302 S R D L E K V S Q Q I A K P F
Baker's Yeast Sacchar. cerevisiae P54839 491 54995 R332 V D A E L A T R D Y D E S L T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.2 89.1 N.A. 89.3 88.9 N.A. 64.1 61.6 62.3 61.8 N.A. 55.3 52.7 39.7 57.4
Protein Similarity: 100 99.6 98.4 93.9 N.A. 95 95 N.A. 73 75.6 76.7 75.7 N.A. 67.7 70 55.1 71.6
P-Site Identity: 100 100 100 93.3 N.A. 86.6 86.6 N.A. 0 6.6 6.6 6.6 N.A. 13.3 0 0 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 6.6 6.6 6.6 13.3 N.A. 13.3 13.3 20 20
Percent
Protein Identity: N.A. N.A. N.A. 42.3 42.1 N.A.
Protein Similarity: N.A. N.A. N.A. 59.4 62.4 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 32 0 0 13 19 7 0 0 7 7 7 0 57 % A
% Cys: 19 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 7 7 0 32 0 7 7 7 0 44 7 38 7 0 % D
% Glu: 0 0 0 44 25 7 7 0 7 7 0 13 0 7 0 % E
% Phe: 7 0 0 7 0 0 0 0 0 0 7 7 0 0 7 % F
% Gly: 7 0 0 7 0 0 0 0 0 0 0 7 0 0 0 % G
% His: 0 7 0 0 0 0 0 0 7 0 0 0 7 0 0 % H
% Ile: 0 7 0 0 0 0 0 0 7 0 7 0 7 0 0 % I
% Lys: 0 38 7 0 7 7 7 0 0 44 7 0 13 38 7 % K
% Leu: 38 19 38 19 25 25 7 0 7 0 7 19 0 25 0 % L
% Met: 0 0 0 0 0 0 0 7 0 0 0 7 7 7 0 % M
% Asn: 0 0 0 0 0 0 0 0 44 7 0 7 7 0 0 % N
% Pro: 0 0 7 0 0 0 0 0 0 0 19 0 0 7 0 % P
% Gln: 0 0 7 0 0 0 0 19 7 13 0 13 13 7 7 % Q
% Arg: 0 19 0 0 0 13 0 7 0 0 0 0 0 0 0 % R
% Ser: 13 0 0 25 0 0 0 7 0 13 0 7 7 0 0 % S
% Thr: 7 7 0 0 0 38 13 38 7 7 0 0 0 7 7 % T
% Val: 7 0 0 0 13 0 7 7 0 0 7 13 0 0 13 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 7 0 0 0 38 7 13 13 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _