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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCS2
All Species:
21.52
Human Site:
T368
Identified Species:
31.56
UniProt:
P54868
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54868
NP_005509.1
508
56635
T368
Q
D
M
F
D
K
K
T
K
A
S
L
Y
L
S
Chimpanzee
Pan troglodytes
XP_513693
508
56570
T368
Q
D
M
F
D
K
K
T
K
A
S
L
Y
L
S
Rhesus Macaque
Macaca mulatta
XP_001114146
508
56631
T368
Q
D
I
F
D
K
K
T
K
A
S
L
Y
L
S
Dog
Lupus familis
XP_849878
508
56870
T368
L
D
S
F
N
K
K
T
K
A
S
L
Y
L
S
Cat
Felis silvestris
Mouse
Mus musculus
P54869
508
56804
T368
L
D
M
F
N
Q
K
T
K
A
S
L
Y
L
S
Rat
Rattus norvegicus
P22791
508
56893
T368
L
D
M
F
N
K
K
T
K
A
S
L
Y
L
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521387
594
65294
N454
K
A
S
Q
D
V
F
N
Q
K
T
K
P
S
L
Chicken
Gallus gallus
P23228
522
57541
F380
E
F
S
Y
G
S
G
F
A
A
T
L
Y
S
I
Frog
Xenopus laevis
NP_001080399
520
57209
F380
V
F
S
Y
G
S
G
F
A
A
T
L
Y
S
L
Zebra Danio
Brachydanio rerio
NP_957379
508
55918
F369
V
F
S
Y
G
S
G
F
A
A
T
L
Y
S
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524711
465
51158
L326
A
S
K
T
K
K
S
L
L
L
A
N
Q
V
G
Honey Bee
Apis mellifera
XP_397202
453
50855
K314
S
K
N
I
F
M
Q
K
T
Q
P
S
L
M
I
Nematode Worm
Caenorhab. elegans
P54871
462
51397
R323
D
P
Y
L
V
F
N
R
R
I
G
N
M
Y
T
Sea Urchin
Strong. purpuratus
XP_801879
508
56054
A361
G
G
L
V
S
Y
I
A
S
V
P
L
D
E
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54873
461
51076
K322
Q
P
T
T
L
I
P
K
E
V
G
N
M
Y
T
Baker's Yeast
Sacchar. cerevisiae
P54839
491
54995
K352
K
T
F
V
N
V
A
K
P
F
H
K
E
R
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.2
89.1
N.A.
89.3
88.9
N.A.
64.1
61.6
62.3
61.8
N.A.
55.3
52.7
39.7
57.4
Protein Similarity:
100
99.6
98.4
93.9
N.A.
95
95
N.A.
73
75.6
76.7
75.7
N.A.
67.7
70
55.1
71.6
P-Site Identity:
100
100
93.3
80
N.A.
80
86.6
N.A.
6.6
20
20
20
N.A.
6.6
0
0
6.6
P-Site Similarity:
100
100
100
86.6
N.A.
93.3
93.3
N.A.
26.6
40
33.3
33.3
N.A.
20
13.3
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.3
42.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.4
62.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
0
0
0
7
7
19
57
7
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
38
0
0
25
0
0
0
0
0
0
0
7
0
0
% D
% Glu:
7
0
0
0
0
0
0
0
7
0
0
0
7
7
0
% E
% Phe:
0
19
7
38
7
7
7
19
0
7
0
0
0
0
0
% F
% Gly:
7
7
0
0
19
0
19
0
0
0
13
0
0
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% H
% Ile:
0
0
7
7
0
7
7
0
0
7
0
0
0
0
19
% I
% Lys:
13
7
7
0
7
38
38
19
38
7
0
13
0
0
0
% K
% Leu:
19
0
7
7
7
0
0
7
7
7
0
63
7
38
19
% L
% Met:
0
0
25
0
0
7
0
0
0
0
0
0
13
7
0
% M
% Asn:
0
0
7
0
25
0
7
7
0
0
0
19
0
0
0
% N
% Pro:
0
13
0
0
0
0
7
0
7
0
13
0
7
0
0
% P
% Gln:
25
0
0
7
0
7
7
0
7
7
0
0
7
0
0
% Q
% Arg:
0
0
0
0
0
0
0
7
7
0
0
0
0
7
0
% R
% Ser:
7
7
32
0
7
19
7
0
7
0
38
7
0
25
38
% S
% Thr:
0
7
7
13
0
0
0
38
7
0
25
0
0
0
13
% T
% Val:
13
0
0
13
7
13
0
0
0
13
0
0
0
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
19
0
7
0
0
0
0
0
0
57
13
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _