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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCS2
All Species:
28.48
Human Site:
Y189
Identified Species:
41.78
UniProt:
P54868
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54868
NP_005509.1
508
56635
Y189
S
S
S
W
D
G
R
Y
A
M
V
V
C
G
D
Chimpanzee
Pan troglodytes
XP_513693
508
56570
Y189
S
S
S
W
D
G
R
Y
A
M
V
V
C
G
D
Rhesus Macaque
Macaca mulatta
XP_001114146
508
56631
Y189
S
S
S
W
D
G
R
Y
A
M
V
V
C
G
D
Dog
Lupus familis
XP_849878
508
56870
Y189
S
S
S
W
D
G
R
Y
A
M
V
V
C
G
D
Cat
Felis silvestris
Mouse
Mus musculus
P54869
508
56804
Y189
S
S
Y
W
D
G
R
Y
A
L
V
V
C
G
D
Rat
Rattus norvegicus
P22791
508
56893
Y189
S
S
Y
W
D
G
R
Y
A
L
V
V
C
G
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521387
594
65294
Y278
S
S
S
W
D
G
R
Y
A
L
V
V
C
G
D
Chicken
Gallus gallus
P23228
522
57541
Y202
G
T
H
M
Q
H
A
Y
D
F
Y
K
P
D
M
Frog
Xenopus laevis
NP_001080399
520
57209
Y202
G
T
H
M
Q
H
A
Y
D
F
Y
K
P
D
M
Zebra Danio
Brachydanio rerio
NP_957379
508
55918
Y191
G
T
H
M
Q
H
A
Y
D
F
Y
K
P
D
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524711
465
51158
K157
A
D
I
A
V
Y
A
K
G
A
A
R
P
T
G
Honey Bee
Apis mellifera
XP_397202
453
50855
V145
D
G
R
L
A
L
V
V
A
G
D
N
A
V
Y
Nematode Worm
Caenorhab. elegans
P54871
462
51397
A154
K
N
A
I
V
V
V
A
D
I
A
I
Y
E
E
Sea Urchin
Strong. purpuratus
XP_801879
508
56054
R192
H
A
P
L
V
I
E
R
G
L
R
S
T
H
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54873
461
51076
E153
T
D
S
A
V
Y
A
E
G
P
A
R
P
T
G
Baker's Yeast
Sacchar. cerevisiae
P54839
491
54995
A183
N
A
W
D
G
R
D
A
I
V
V
C
G
D
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.2
89.1
N.A.
89.3
88.9
N.A.
64.1
61.6
62.3
61.8
N.A.
55.3
52.7
39.7
57.4
Protein Similarity:
100
99.6
98.4
93.9
N.A.
95
95
N.A.
73
75.6
76.7
75.7
N.A.
67.7
70
55.1
71.6
P-Site Identity:
100
100
100
100
N.A.
86.6
86.6
N.A.
93.3
6.6
6.6
6.6
N.A.
0
6.6
0
0
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
100
13.3
13.3
13.3
N.A.
6.6
6.6
33.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.3
42.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.4
62.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
13
7
13
7
0
32
13
50
7
19
0
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
7
44
0
0
% C
% Asp:
7
13
0
7
44
0
7
0
25
0
7
0
0
25
44
% D
% Glu:
0
0
0
0
0
0
7
7
0
0
0
0
0
7
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
19
0
0
0
0
0
% F
% Gly:
19
7
0
0
7
44
0
0
19
7
0
0
7
44
13
% G
% His:
7
0
19
0
0
19
0
0
0
0
0
0
0
7
0
% H
% Ile:
0
0
7
7
0
7
0
0
7
7
0
7
0
0
7
% I
% Lys:
7
0
0
0
0
0
0
7
0
0
0
19
0
0
0
% K
% Leu:
0
0
0
13
0
7
0
0
0
25
0
0
0
0
0
% L
% Met:
0
0
0
19
0
0
0
0
0
25
0
0
0
0
25
% M
% Asn:
7
7
0
0
0
0
0
0
0
0
0
7
0
0
0
% N
% Pro:
0
0
7
0
0
0
0
0
0
7
0
0
32
0
0
% P
% Gln:
0
0
0
0
19
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
7
0
0
7
44
7
0
0
7
13
0
0
0
% R
% Ser:
44
44
38
0
0
0
0
0
0
0
0
7
0
0
0
% S
% Thr:
7
19
0
0
0
0
0
0
0
0
0
0
7
13
0
% T
% Val:
0
0
0
0
25
7
13
7
0
7
50
44
0
7
0
% V
% Trp:
0
0
7
44
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
13
0
0
13
0
63
0
0
19
0
7
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _