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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCS2 All Species: 24.24
Human Site: Y239 Identified Species: 35.56
UniProt: P54868 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54868 NP_005509.1 508 56635 Y239 G T H M E N V Y D F Y K P N L
Chimpanzee Pan troglodytes XP_513693 508 56570 Y239 G T H M E N A Y D F Y K P N L
Rhesus Macaque Macaca mulatta XP_001114146 508 56631 Y239 G T H M E N V Y D F Y K P N L
Dog Lupus familis XP_849878 508 56870 Y239 G T H M E N V Y D F Y K P D A
Cat Felis silvestris
Mouse Mus musculus P54869 508 56804 Y239 G T H M E N A Y D F Y K P N L
Rat Rattus norvegicus P22791 508 56893 Y239 G T H M E N A Y D F Y K P N L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521387 594 65294 E325 G L R G T H M E N A Y D F Y K
Chicken Gallus gallus P23228 522 57541 R251 W Q K E G T D R G F T L N D F
Frog Xenopus laevis NP_001080399 520 57209 K251 W Q K E G T D K P F T L N D F
Zebra Danio Brachydanio rerio NP_957379 508 55918 G240 W Q R E G T E G R C S L E D F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524711 465 51158 Y197 M E H A Y D F Y K P D L S S E
Honey Bee Apis mellifera XP_397202 453 50855 S185 I D R G V R S S C M K H V Y D
Nematode Worm Caenorhab. elegans P54871 462 51397 M194 R Q F S A C H M K N T W D F F
Sea Urchin Strong. purpuratus XP_801879 508 56054 K232 C Y L G A L D K C Y E R Y I A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P54873 461 51076 Y193 M A H V Y D F Y K P N L A S E
Baker's Yeast Sacchar. cerevisiae P54839 491 54995 R223 P I V F D S V R A S Y M E H A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.2 89.1 N.A. 89.3 88.9 N.A. 64.1 61.6 62.3 61.8 N.A. 55.3 52.7 39.7 57.4
Protein Similarity: 100 99.6 98.4 93.9 N.A. 95 95 N.A. 73 75.6 76.7 75.7 N.A. 67.7 70 55.1 71.6
P-Site Identity: 100 93.3 100 86.6 N.A. 93.3 93.3 N.A. 13.3 6.6 6.6 0 N.A. 13.3 0 0 0
P-Site Similarity: 100 93.3 100 93.3 N.A. 93.3 93.3 N.A. 33.3 13.3 13.3 6.6 N.A. 26.6 0 0 13.3
Percent
Protein Identity: N.A. N.A. N.A. 42.3 42.1 N.A.
Protein Similarity: N.A. N.A. N.A. 59.4 62.4 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 7 13 0 19 0 7 7 0 0 7 0 19 % A
% Cys: 7 0 0 0 0 7 0 0 13 7 0 0 0 0 0 % C
% Asp: 0 7 0 0 7 13 19 0 38 0 7 7 7 25 7 % D
% Glu: 0 7 0 19 38 0 7 7 0 0 7 0 13 0 13 % E
% Phe: 0 0 7 7 0 0 13 0 0 50 0 0 7 7 25 % F
% Gly: 44 0 0 19 19 0 0 7 7 0 0 0 0 0 0 % G
% His: 0 0 50 0 0 7 7 0 0 0 0 7 0 7 0 % H
% Ile: 7 7 0 0 0 0 0 0 0 0 0 0 0 7 0 % I
% Lys: 0 0 13 0 0 0 0 13 19 0 7 38 0 0 7 % K
% Leu: 0 7 7 0 0 7 0 0 0 0 0 32 0 0 32 % L
% Met: 13 0 0 38 0 0 7 7 0 7 0 7 0 0 0 % M
% Asn: 0 0 0 0 0 38 0 0 7 7 7 0 13 32 0 % N
% Pro: 7 0 0 0 0 0 0 0 7 13 0 0 38 0 0 % P
% Gln: 0 25 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 7 0 19 0 0 7 0 13 7 0 0 7 0 0 0 % R
% Ser: 0 0 0 7 0 7 7 7 0 7 7 0 7 13 0 % S
% Thr: 0 38 0 0 7 19 0 0 0 0 19 0 0 0 0 % T
% Val: 0 0 7 7 7 0 25 0 0 0 0 0 7 0 0 % V
% Trp: 19 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % W
% Tyr: 0 7 0 0 13 0 0 50 0 7 50 0 7 13 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _