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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCS2 All Species: 24.55
Human Site: Y270 Identified Species: 36
UniProt: P54868 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.33
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54868 NP_005509.1 508 56635 Y270 L R A L D R C Y T S Y R K K I
Chimpanzee Pan troglodytes XP_513693 508 56570 Y270 L R A L D R C Y T S Y R K K I
Rhesus Macaque Macaca mulatta XP_001114146 508 56631 Y270 L R A L D R C Y T S Y R K K I
Dog Lupus familis XP_849878 508 56870 Y270 L R A L D R C Y T L Y R Q K I
Cat Felis silvestris
Mouse Mus musculus P54869 508 56804 Y270 L R A L D R C Y A A Y R K K I
Rat Rattus norvegicus P22791 508 56893 Y270 L R A L D R C Y A A Y R R K I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521387 594 65294 D356 L C Y L R A L D R C Y A F Y R
Chicken Gallus gallus P23228 522 57541 D282 V A R L L L N D F L S D Q N A
Frog Xenopus laevis NP_001080399 520 57209 D282 L A R L L V N D F I S D S N P
Zebra Danio Brachydanio rerio NP_957379 508 55918 D271 L A R L M L N D F L C H P S P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524711 465 51158 Y228 L D T C Y R L Y R K K F D Q Q
Honey Bee Apis mellifera XP_397202 453 50855 S216 L S I Q C Y L S A L D T C Y Q
Nematode Worm Caenorhab. elegans P54871 462 51397 E225 L S L S S Y L E A V R M T Y T
Sea Urchin Strong. purpuratus XP_801879 508 56054 C263 V D S F D G M C F H S P F C K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P54873 461 51076 L224 L D S C Y K H L C N K F E K I
Baker's Yeast Sacchar. cerevisiae P54839 491 54995 Y254 G H F S L T C Y V K A L D Q V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.2 89.1 N.A. 89.3 88.9 N.A. 64.1 61.6 62.3 61.8 N.A. 55.3 52.7 39.7 57.4
Protein Similarity: 100 99.6 98.4 93.9 N.A. 95 95 N.A. 73 75.6 76.7 75.7 N.A. 67.7 70 55.1 71.6
P-Site Identity: 100 100 100 86.6 N.A. 86.6 80 N.A. 20 6.6 13.3 13.3 N.A. 20 6.6 6.6 6.6
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 20 20 13.3 13.3 N.A. 26.6 6.6 6.6 20
Percent
Protein Identity: N.A. N.A. N.A. 42.3 42.1 N.A.
Protein Similarity: N.A. N.A. N.A. 59.4 62.4 N.A.
P-Site Identity: N.A. N.A. N.A. 20 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 46.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 19 38 0 0 7 0 0 25 13 7 7 0 0 7 % A
% Cys: 0 7 0 13 7 0 44 7 7 7 7 0 7 7 0 % C
% Asp: 0 19 0 0 44 0 0 25 0 0 7 13 13 0 0 % D
% Glu: 0 0 0 0 0 0 0 7 0 0 0 0 7 0 0 % E
% Phe: 0 0 7 7 0 0 0 0 25 0 0 13 13 0 0 % F
% Gly: 7 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % G
% His: 0 7 0 0 0 0 7 0 0 7 0 7 0 0 0 % H
% Ile: 0 0 7 0 0 0 0 0 0 7 0 0 0 0 44 % I
% Lys: 0 0 0 0 0 7 0 0 0 13 13 0 25 44 7 % K
% Leu: 82 0 7 63 19 13 25 7 0 25 0 7 0 0 0 % L
% Met: 0 0 0 0 7 0 7 0 0 0 0 7 0 0 0 % M
% Asn: 0 0 0 0 0 0 19 0 0 7 0 0 0 13 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 7 7 0 13 % P
% Gln: 0 0 0 7 0 0 0 0 0 0 0 0 13 13 13 % Q
% Arg: 0 38 19 0 7 44 0 0 13 0 7 38 7 0 7 % R
% Ser: 0 13 13 13 7 0 0 7 0 19 19 0 7 7 0 % S
% Thr: 0 0 7 0 0 7 0 0 25 0 0 7 7 0 7 % T
% Val: 13 0 0 0 0 7 0 0 7 7 0 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 7 0 13 13 0 50 0 0 44 0 0 19 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _