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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCS2
All Species:
24.55
Human Site:
Y270
Identified Species:
36
UniProt:
P54868
Number Species:
15
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54868
NP_005509.1
508
56635
Y270
L
R
A
L
D
R
C
Y
T
S
Y
R
K
K
I
Chimpanzee
Pan troglodytes
XP_513693
508
56570
Y270
L
R
A
L
D
R
C
Y
T
S
Y
R
K
K
I
Rhesus Macaque
Macaca mulatta
XP_001114146
508
56631
Y270
L
R
A
L
D
R
C
Y
T
S
Y
R
K
K
I
Dog
Lupus familis
XP_849878
508
56870
Y270
L
R
A
L
D
R
C
Y
T
L
Y
R
Q
K
I
Cat
Felis silvestris
Mouse
Mus musculus
P54869
508
56804
Y270
L
R
A
L
D
R
C
Y
A
A
Y
R
K
K
I
Rat
Rattus norvegicus
P22791
508
56893
Y270
L
R
A
L
D
R
C
Y
A
A
Y
R
R
K
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521387
594
65294
D356
L
C
Y
L
R
A
L
D
R
C
Y
A
F
Y
R
Chicken
Gallus gallus
P23228
522
57541
D282
V
A
R
L
L
L
N
D
F
L
S
D
Q
N
A
Frog
Xenopus laevis
NP_001080399
520
57209
D282
L
A
R
L
L
V
N
D
F
I
S
D
S
N
P
Zebra Danio
Brachydanio rerio
NP_957379
508
55918
D271
L
A
R
L
M
L
N
D
F
L
C
H
P
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524711
465
51158
Y228
L
D
T
C
Y
R
L
Y
R
K
K
F
D
Q
Q
Honey Bee
Apis mellifera
XP_397202
453
50855
S216
L
S
I
Q
C
Y
L
S
A
L
D
T
C
Y
Q
Nematode Worm
Caenorhab. elegans
P54871
462
51397
E225
L
S
L
S
S
Y
L
E
A
V
R
M
T
Y
T
Sea Urchin
Strong. purpuratus
XP_801879
508
56054
C263
V
D
S
F
D
G
M
C
F
H
S
P
F
C
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54873
461
51076
L224
L
D
S
C
Y
K
H
L
C
N
K
F
E
K
I
Baker's Yeast
Sacchar. cerevisiae
P54839
491
54995
Y254
G
H
F
S
L
T
C
Y
V
K
A
L
D
Q
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.2
89.1
N.A.
89.3
88.9
N.A.
64.1
61.6
62.3
61.8
N.A.
55.3
52.7
39.7
57.4
Protein Similarity:
100
99.6
98.4
93.9
N.A.
95
95
N.A.
73
75.6
76.7
75.7
N.A.
67.7
70
55.1
71.6
P-Site Identity:
100
100
100
86.6
N.A.
86.6
80
N.A.
20
6.6
13.3
13.3
N.A.
20
6.6
6.6
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
20
20
13.3
13.3
N.A.
26.6
6.6
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.3
42.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.4
62.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
19
38
0
0
7
0
0
25
13
7
7
0
0
7
% A
% Cys:
0
7
0
13
7
0
44
7
7
7
7
0
7
7
0
% C
% Asp:
0
19
0
0
44
0
0
25
0
0
7
13
13
0
0
% D
% Glu:
0
0
0
0
0
0
0
7
0
0
0
0
7
0
0
% E
% Phe:
0
0
7
7
0
0
0
0
25
0
0
13
13
0
0
% F
% Gly:
7
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% G
% His:
0
7
0
0
0
0
7
0
0
7
0
7
0
0
0
% H
% Ile:
0
0
7
0
0
0
0
0
0
7
0
0
0
0
44
% I
% Lys:
0
0
0
0
0
7
0
0
0
13
13
0
25
44
7
% K
% Leu:
82
0
7
63
19
13
25
7
0
25
0
7
0
0
0
% L
% Met:
0
0
0
0
7
0
7
0
0
0
0
7
0
0
0
% M
% Asn:
0
0
0
0
0
0
19
0
0
7
0
0
0
13
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
7
7
0
13
% P
% Gln:
0
0
0
7
0
0
0
0
0
0
0
0
13
13
13
% Q
% Arg:
0
38
19
0
7
44
0
0
13
0
7
38
7
0
7
% R
% Ser:
0
13
13
13
7
0
0
7
0
19
19
0
7
7
0
% S
% Thr:
0
0
7
0
0
7
0
0
25
0
0
7
7
0
7
% T
% Val:
13
0
0
0
0
7
0
0
7
7
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
13
13
0
50
0
0
44
0
0
19
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _