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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCS2
All Species:
20.3
Human Site:
Y332
Identified Species:
29.78
UniProt:
P54868
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54868
NP_005509.1
508
56635
Y332
S
D
T
Q
T
S
L
Y
K
G
L
E
A
F
G
Chimpanzee
Pan troglodytes
XP_513693
508
56570
Y332
S
D
T
Q
T
S
L
Y
K
G
L
E
A
F
G
Rhesus Macaque
Macaca mulatta
XP_001114146
508
56631
Y332
S
D
T
Q
T
S
L
Y
K
G
L
E
A
F
R
Dog
Lupus familis
XP_849878
508
56870
Y332
S
D
T
Q
T
S
L
Y
K
E
L
E
T
F
R
Cat
Felis silvestris
Mouse
Mus musculus
P54869
508
56804
Y332
S
D
K
Q
N
N
L
Y
K
G
L
E
A
F
R
Rat
Rattus norvegicus
P22791
508
56893
Y332
S
D
K
Q
N
N
L
Y
K
G
L
E
A
F
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521387
594
65294
N418
A
G
S
S
G
P
R
N
G
S
Y
Q
G
L
E
Chicken
Gallus gallus
P23228
522
57541
N344
L
V
S
N
Q
N
G
N
M
Y
T
P
S
V
Y
Frog
Xenopus laevis
NP_001080399
520
57209
N344
L
V
S
K
E
N
G
N
M
Y
T
P
S
V
Y
Zebra Danio
Brachydanio rerio
NP_957379
508
55918
N333
L
I
S
N
Q
N
G
N
M
Y
T
P
S
V
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524711
465
51158
E290
T
K
Q
F
P
D
L
E
R
F
N
T
A
T
L
Honey Bee
Apis mellifera
XP_397202
453
50855
K278
S
K
E
E
I
S
K
K
Y
P
E
L
E
K
F
Nematode Worm
Caenorhab. elegans
P54871
462
51397
G287
H
K
Q
L
N
G
N
G
V
D
H
K
L
D
E
Sea Urchin
Strong. purpuratus
XP_801879
508
56054
A325
V
E
K
A
F
M
T
A
S
K
E
V
Y
Q
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54873
461
51076
S286
E
K
F
T
P
Y
S
S
L
T
L
D
E
S
Y
Baker's Yeast
Sacchar. cerevisiae
P54839
491
54995
R316
R
L
L
Y
N
D
F
R
A
N
P
Q
L
F
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.2
89.1
N.A.
89.3
88.9
N.A.
64.1
61.6
62.3
61.8
N.A.
55.3
52.7
39.7
57.4
Protein Similarity:
100
99.6
98.4
93.9
N.A.
95
95
N.A.
73
75.6
76.7
75.7
N.A.
67.7
70
55.1
71.6
P-Site Identity:
100
100
93.3
80
N.A.
73.3
73.3
N.A.
0
0
0
0
N.A.
13.3
13.3
0
0
P-Site Similarity:
100
100
93.3
80
N.A.
80
80
N.A.
20
20
26.6
20
N.A.
26.6
20
6.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.3
42.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.4
62.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
7
0
0
0
7
7
0
0
0
38
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
38
0
0
0
13
0
0
0
7
0
7
0
7
0
% D
% Glu:
7
7
7
7
7
0
0
7
0
7
13
38
13
0
13
% E
% Phe:
0
0
7
7
7
0
7
0
0
7
0
0
0
44
7
% F
% Gly:
0
7
0
0
7
7
19
7
7
32
0
0
7
0
13
% G
% His:
7
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% H
% Ile:
0
7
0
0
7
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
25
19
7
0
0
7
7
38
7
0
7
0
7
7
% K
% Leu:
19
7
7
7
0
0
44
0
7
0
44
7
13
7
7
% L
% Met:
0
0
0
0
0
7
0
0
19
0
0
0
0
0
0
% M
% Asn:
0
0
0
13
25
32
7
25
0
7
7
0
0
0
0
% N
% Pro:
0
0
0
0
13
7
0
0
0
7
7
19
0
0
7
% P
% Gln:
0
0
13
38
13
0
0
0
0
0
0
13
0
7
7
% Q
% Arg:
7
0
0
0
0
0
7
7
7
0
0
0
0
0
19
% R
% Ser:
44
0
25
7
0
32
7
7
7
7
0
0
19
7
0
% S
% Thr:
7
0
25
7
25
0
7
0
0
7
19
7
7
7
0
% T
% Val:
7
13
0
0
0
0
0
0
7
0
0
7
0
19
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
0
7
0
38
7
19
7
0
7
0
25
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _