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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCS2
All Species:
27.58
Human Site:
Y373
Identified Species:
40.44
UniProt:
P54868
Number Species:
15
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54868
NP_005509.1
508
56635
Y373
K
K
T
K
A
S
L
Y
L
S
T
H
N
G
N
Chimpanzee
Pan troglodytes
XP_513693
508
56570
Y373
K
K
T
K
A
S
L
Y
L
S
T
H
N
G
N
Rhesus Macaque
Macaca mulatta
XP_001114146
508
56631
Y373
K
K
T
K
A
S
L
Y
L
S
T
H
N
G
N
Dog
Lupus familis
XP_849878
508
56870
Y373
K
K
T
K
A
S
L
Y
L
S
T
H
N
G
N
Cat
Felis silvestris
Mouse
Mus musculus
P54869
508
56804
Y373
Q
K
T
K
A
S
L
Y
L
S
T
N
N
G
N
Rat
Rattus norvegicus
P22791
508
56893
Y373
K
K
T
K
A
S
L
Y
L
S
T
N
N
G
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521387
594
65294
P459
V
F
N
Q
K
T
K
P
S
L
F
L
S
T
H
Chicken
Gallus gallus
P23228
522
57541
Y385
S
G
F
A
A
T
L
Y
S
I
R
V
T
Q
D
Frog
Xenopus laevis
NP_001080399
520
57209
Y385
S
G
F
A
A
T
L
Y
S
L
R
V
S
Q
D
Zebra Danio
Brachydanio rerio
NP_957379
508
55918
Y374
S
G
F
A
A
T
L
Y
S
I
K
V
T
Q
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524711
465
51158
Q331
K
S
L
L
L
A
N
Q
V
G
N
M
Y
T
P
Honey Bee
Apis mellifera
XP_397202
453
50855
L319
M
Q
K
T
Q
P
S
L
M
I
P
S
Q
V
G
Nematode Worm
Caenorhab. elegans
P54871
462
51397
M328
F
N
R
R
I
G
N
M
Y
T
P
S
L
F
A
Sea Urchin
Strong. purpuratus
XP_801879
508
56054
D366
Y
I
A
S
V
P
L
D
E
L
P
N
K
R
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54873
461
51076
M327
I
P
K
E
V
G
N
M
Y
T
A
S
L
Y
A
Baker's Yeast
Sacchar. cerevisiae
P54839
491
54995
E357
V
A
K
P
F
H
K
E
R
V
A
Q
S
L
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.2
89.1
N.A.
89.3
88.9
N.A.
64.1
61.6
62.3
61.8
N.A.
55.3
52.7
39.7
57.4
Protein Similarity:
100
99.6
98.4
93.9
N.A.
95
95
N.A.
73
75.6
76.7
75.7
N.A.
67.7
70
55.1
71.6
P-Site Identity:
100
100
100
100
N.A.
86.6
93.3
N.A.
0
20
20
20
N.A.
6.6
0
0
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
26.6
33.3
40
33.3
N.A.
20
13.3
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.3
42.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.4
62.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
19
57
7
0
0
0
0
13
0
0
0
13
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
19
% D
% Glu:
0
0
0
7
0
0
0
7
7
0
0
0
0
0
0
% E
% Phe:
7
7
19
0
7
0
0
0
0
0
7
0
0
7
0
% F
% Gly:
0
19
0
0
0
13
0
0
0
7
0
0
0
38
7
% G
% His:
0
0
0
0
0
7
0
0
0
0
0
25
0
0
7
% H
% Ile:
7
7
0
0
7
0
0
0
0
19
0
0
0
0
13
% I
% Lys:
38
38
19
38
7
0
13
0
0
0
7
0
7
0
0
% K
% Leu:
0
0
7
7
7
0
63
7
38
19
0
7
13
7
0
% L
% Met:
7
0
0
0
0
0
0
13
7
0
0
7
0
0
0
% M
% Asn:
0
7
7
0
0
0
19
0
0
0
7
19
38
0
38
% N
% Pro:
0
7
0
7
0
13
0
7
0
0
19
0
0
0
7
% P
% Gln:
7
7
0
7
7
0
0
7
0
0
0
7
7
19
0
% Q
% Arg:
0
0
7
7
0
0
0
0
7
0
13
0
0
7
0
% R
% Ser:
19
7
0
7
0
38
7
0
25
38
0
19
19
0
0
% S
% Thr:
0
0
38
7
0
25
0
0
0
13
38
0
13
13
0
% T
% Val:
13
0
0
0
13
0
0
0
7
7
0
19
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
57
13
0
0
0
7
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _