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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCS2 All Species: 27.58
Human Site: Y373 Identified Species: 40.44
UniProt: P54868 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54868 NP_005509.1 508 56635 Y373 K K T K A S L Y L S T H N G N
Chimpanzee Pan troglodytes XP_513693 508 56570 Y373 K K T K A S L Y L S T H N G N
Rhesus Macaque Macaca mulatta XP_001114146 508 56631 Y373 K K T K A S L Y L S T H N G N
Dog Lupus familis XP_849878 508 56870 Y373 K K T K A S L Y L S T H N G N
Cat Felis silvestris
Mouse Mus musculus P54869 508 56804 Y373 Q K T K A S L Y L S T N N G N
Rat Rattus norvegicus P22791 508 56893 Y373 K K T K A S L Y L S T N N G N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521387 594 65294 P459 V F N Q K T K P S L F L S T H
Chicken Gallus gallus P23228 522 57541 Y385 S G F A A T L Y S I R V T Q D
Frog Xenopus laevis NP_001080399 520 57209 Y385 S G F A A T L Y S L R V S Q D
Zebra Danio Brachydanio rerio NP_957379 508 55918 Y374 S G F A A T L Y S I K V T Q D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524711 465 51158 Q331 K S L L L A N Q V G N M Y T P
Honey Bee Apis mellifera XP_397202 453 50855 L319 M Q K T Q P S L M I P S Q V G
Nematode Worm Caenorhab. elegans P54871 462 51397 M328 F N R R I G N M Y T P S L F A
Sea Urchin Strong. purpuratus XP_801879 508 56054 D366 Y I A S V P L D E L P N K R I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P54873 461 51076 M327 I P K E V G N M Y T A S L Y A
Baker's Yeast Sacchar. cerevisiae P54839 491 54995 E357 V A K P F H K E R V A Q S L I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.2 89.1 N.A. 89.3 88.9 N.A. 64.1 61.6 62.3 61.8 N.A. 55.3 52.7 39.7 57.4
Protein Similarity: 100 99.6 98.4 93.9 N.A. 95 95 N.A. 73 75.6 76.7 75.7 N.A. 67.7 70 55.1 71.6
P-Site Identity: 100 100 100 100 N.A. 86.6 93.3 N.A. 0 20 20 20 N.A. 6.6 0 0 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 26.6 33.3 40 33.3 N.A. 20 13.3 13.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. 42.3 42.1 N.A.
Protein Similarity: N.A. N.A. N.A. 59.4 62.4 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 7 19 57 7 0 0 0 0 13 0 0 0 13 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 19 % D
% Glu: 0 0 0 7 0 0 0 7 7 0 0 0 0 0 0 % E
% Phe: 7 7 19 0 7 0 0 0 0 0 7 0 0 7 0 % F
% Gly: 0 19 0 0 0 13 0 0 0 7 0 0 0 38 7 % G
% His: 0 0 0 0 0 7 0 0 0 0 0 25 0 0 7 % H
% Ile: 7 7 0 0 7 0 0 0 0 19 0 0 0 0 13 % I
% Lys: 38 38 19 38 7 0 13 0 0 0 7 0 7 0 0 % K
% Leu: 0 0 7 7 7 0 63 7 38 19 0 7 13 7 0 % L
% Met: 7 0 0 0 0 0 0 13 7 0 0 7 0 0 0 % M
% Asn: 0 7 7 0 0 0 19 0 0 0 7 19 38 0 38 % N
% Pro: 0 7 0 7 0 13 0 7 0 0 19 0 0 0 7 % P
% Gln: 7 7 0 7 7 0 0 7 0 0 0 7 7 19 0 % Q
% Arg: 0 0 7 7 0 0 0 0 7 0 13 0 0 7 0 % R
% Ser: 19 7 0 7 0 38 7 0 25 38 0 19 19 0 0 % S
% Thr: 0 0 38 7 0 25 0 0 0 13 38 0 13 13 0 % T
% Val: 13 0 0 0 13 0 0 0 7 7 0 19 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 0 0 0 0 0 57 13 0 0 0 7 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _