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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCS2
All Species:
23.94
Human Site:
Y382
Identified Species:
35.11
UniProt:
P54868
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54868
NP_005509.1
508
56635
Y382
S
T
H
N
G
N
M
Y
T
S
S
L
Y
G
C
Chimpanzee
Pan troglodytes
XP_513693
508
56570
Y382
S
T
H
N
G
N
M
Y
T
S
S
L
Y
G
C
Rhesus Macaque
Macaca mulatta
XP_001114146
508
56631
Y382
S
T
H
N
G
N
M
Y
T
S
S
L
Y
G
C
Dog
Lupus familis
XP_849878
508
56870
Y382
S
T
H
N
G
N
M
Y
T
S
S
L
Y
G
C
Cat
Felis silvestris
Mouse
Mus musculus
P54869
508
56804
Y382
S
T
N
N
G
N
M
Y
T
S
S
L
Y
G
C
Rat
Rattus norvegicus
P22791
508
56893
Y382
S
T
N
N
G
N
M
Y
T
S
S
L
Y
G
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521387
594
65294
G468
L
F
L
S
T
H
N
G
N
M
Y
T
P
S
M
Chicken
Gallus gallus
P23228
522
57541
T394
I
R
V
T
Q
D
A
T
P
G
S
A
L
D
K
Frog
Xenopus laevis
NP_001080399
520
57209
M394
L
R
V
S
Q
D
A
M
P
G
S
S
L
D
K
Zebra Danio
Brachydanio rerio
NP_957379
508
55918
T383
I
K
V
T
Q
D
A
T
P
G
S
A
L
D
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524711
465
51158
V340
G
N
M
Y
T
P
S
V
Y
S
G
L
V
S
L
Honey Bee
Apis mellifera
XP_397202
453
50855
M328
I
P
S
Q
V
G
N
M
Y
T
P
S
V
Y
S
Nematode Worm
Caenorhab. elegans
P54871
462
51397
L337
T
P
S
L
F
A
Q
L
L
A
Y
L
A
A
D
Sea Urchin
Strong. purpuratus
XP_801879
508
56054
L375
L
P
N
K
R
I
A
L
F
S
Y
G
S
G
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54873
461
51076
F336
T
A
S
L
Y
A
A
F
A
S
L
I
H
K
K
Baker's Yeast
Sacchar. cerevisiae
P54839
491
54995
P366
V
A
Q
S
L
I
V
P
T
N
T
G
N
M
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.2
89.1
N.A.
89.3
88.9
N.A.
64.1
61.6
62.3
61.8
N.A.
55.3
52.7
39.7
57.4
Protein Similarity:
100
99.6
98.4
93.9
N.A.
95
95
N.A.
73
75.6
76.7
75.7
N.A.
67.7
70
55.1
71.6
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
0
6.6
6.6
6.6
N.A.
13.3
0
6.6
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
13.3
13.3
20
13.3
N.A.
13.3
6.6
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.3
42.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59.4
62.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
13
0
0
0
13
32
0
7
7
0
13
7
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
38
% C
% Asp:
0
0
0
0
0
19
0
0
0
0
0
0
0
19
7
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
7
0
0
7
0
0
7
7
0
0
0
0
0
0
% F
% Gly:
7
0
0
0
38
7
0
7
0
19
7
13
0
44
0
% G
% His:
0
0
25
0
0
7
0
0
0
0
0
0
7
0
0
% H
% Ile:
19
0
0
0
0
13
0
0
0
0
0
7
0
0
0
% I
% Lys:
0
7
0
7
0
0
0
0
0
0
0
0
0
7
25
% K
% Leu:
19
0
7
13
7
0
0
13
7
0
7
50
19
0
7
% L
% Met:
0
0
7
0
0
0
38
13
0
7
0
0
0
7
13
% M
% Asn:
0
7
19
38
0
38
13
0
7
7
0
0
7
0
0
% N
% Pro:
0
19
0
0
0
7
0
7
19
0
7
0
7
0
0
% P
% Gln:
0
0
7
7
19
0
7
0
0
0
0
0
0
0
0
% Q
% Arg:
0
13
0
0
7
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
38
0
19
19
0
0
7
0
0
57
57
13
7
13
7
% S
% Thr:
13
38
0
13
13
0
0
13
44
7
7
7
0
0
0
% T
% Val:
7
0
19
0
7
0
7
7
0
0
0
0
13
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
7
7
0
0
38
13
0
19
0
38
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _